ID   I3M3L4_ICTTR            Unreviewed;       492 AA.
AC   I3M3L4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=Dynein regulatory complex protein 10 {ECO:0000256|ARBA:ARBA00021752};
DE   AltName: Full=IQ domain-containing protein D {ECO:0000256|ARBA:ARBA00032180};
GN   Name=IQCD {ECO:0000313|Ensembl:ENSSTOP00000003680.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000003680.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000003680.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. {ECO:0000256|ARBA:ARBA00003029}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000256|ARBA:ARBA00004611}.
CC   -!- SIMILARITY: Belongs to the DRC10 family.
CC       {ECO:0000256|ARBA:ARBA00009071}.
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DR   EMBL; AGTP01090601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01090602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01090603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3M3L4; -.
DR   STRING; 43179.ENSSTOP00000003680; -.
DR   Ensembl; ENSSTOT00000004103.3; ENSSTOP00000003680.3; ENSSTOG00000004112.3.
DR   eggNOG; ENOG502QQS9; Eukaryota.
DR   GeneTree; ENSGT00730000111354; -.
DR   HOGENOM; CLU_637710_0_0_1; -.
DR   InParanoid; I3M3L4; -.
DR   OrthoDB; 1333124at2759; -.
DR   TreeFam; TF326203; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.190; -; 1.
DR   InterPro; IPR042815; DRC10.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   PANTHER; PTHR31598:SF1; DYNEIN REGULATORY COMPLEX PROTEIN 10; 1.
DR   PANTHER; PTHR31598; IQ DOMAIN-CONTAINING PROTEIN D; 1.
DR   Pfam; PF00612; IQ; 1.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   REGION          427..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          279..377
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   492 AA;  55959 MW;  2B3A74FA8C7C9723 CRC64;
     MALDTLAVTP LHQGPSFSKM PLRTEAWQKP GNLVKPPVPS KSKLTTIEAK RIMSVLDEAI
     YKVELVTLLS YAITHPEALE GMPGEGVAAA VREHQDLCQV LLGTIGDLQE KELQLQAAED
     EEAEEEAWFQ DCLAATAQLK TSLQPQMQKV RDSSRDILRL LLTDPPAARL LRLQALGRSP
     EAQRFIEGLE ELRGFLFERL LTSPMEARDR AQFIQDITRR HRRNQEVIDA LETELTARMK
     NRDSEVEKEN FVIQELKNHL HQVLKFSESS LLRTKQEAEK QQKADSRASQ ARLAKLQQEI
     LTLRSQYHNL VMENREAEQA LRKKKYKVET EIENWIQKYD SEMSEKQEEY EDLDLIHKEE
     KLQLEELKLR HAVLVEEFSQ ILAEREVNAK KRMEAEREML RMIRAATLIQ AVWKGYLVRS
     MLKSKRKKRV KGKGKGKGLS QIKGKGLGQV KGKGLGQVKG KGQVKGKGQG LGKGKGKEKG
     KGKGKEKGKG KK
//