ID I3M3W1_ICTTR Unreviewed; 439 AA.
AC I3M3W1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|Ensembl:ENSSTOP00000003812.3};
GN Name=SOCS4 {ECO:0000313|Ensembl:ENSSTOP00000003812.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000003812.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000003812.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGTP01095633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005338008.1; XM_005337951.2.
DR RefSeq; XP_005338009.1; XM_005337952.2.
DR AlphaFoldDB; I3M3W1; -.
DR STRING; 43179.ENSSTOP00000003812; -.
DR Ensembl; ENSSTOT00000004245.3; ENSSTOP00000003812.3; ENSSTOG00000004262.3.
DR GeneID; 101963360; -.
DR CTD; 122809; -.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000161456; -.
DR HOGENOM; CLU_035609_0_0_1; -.
DR InParanoid; I3M3W1; -.
DR OrthoDB; 5362214at2759; -.
DR TreeFam; TF321368; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 285..380
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 375..424
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 50266 MW; 1BD6833B5570B3CB CRC64;
MAESSENNSK NIDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESCSDAE TVDTIEKTEV
PLRSQERNHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR
KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPISPKSDE WVSTDLSQSE LRDGQLKRRN
LEDVNCFSHT NVQPCVVTTN NASCRGGPMT GSMMNLGPNN SIEDSDMDSD DEIITLCTSS
RKRNKPKWEM DDDILQLETP PKYHTQIDYV HCLVPDLLQI NNNPCYWGVM DKYAAEALLE
GKPEGTFLLR DSAQEDYLFS VSFRRYSRSL HARIEQWNHN FSFDAHDPCV FHSPDITGLL
EHYKDPSACM FFEPLLSTPL IRTFPFSLQH ICRTVICNCT TYDGIDALPI PTSMKLYLKE
YHYKSKVRVL RIDAPEQQC
//
