ID   I3M4G6_ICTTR            Unreviewed;       542 AA.
AC   I3M4G6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Terminal nucleotidyltransferase 4A {ECO:0000313|Ensembl:ENSSTOP00000004085.2};
GN   Name=TENT4A {ECO:0000313|Ensembl:ENSSTOP00000004085.2};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000004085.2, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000004085.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AGTP01081638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005335240.1; XM_005335183.2.
DR   AlphaFoldDB; I3M4G6; -.
DR   STRING; 43179.ENSSTOP00000004085; -.
DR   Ensembl; ENSSTOT00000004553.3; ENSSTOP00000004085.2; ENSSTOG00000004554.3.
DR   GeneID; 101967314; -.
DR   CTD; 11044; -.
DR   eggNOG; KOG1906; Eukaryota.
DR   GeneTree; ENSGT00940000157811; -.
DR   HOGENOM; CLU_013572_3_0_1; -.
DR   InParanoid; I3M4G6; -.
DR   OMA; KWGSRVH; -.
DR   OrthoDB; 21395at2759; -.
DR   TreeFam; TF313939; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0070568; F:guanylyltransferase activity; IEA:Ensembl.
DR   GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0060212; P:negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl.
DR   GO; GO:1905870; P:positive regulation of 3'-UTR-mediated mRNA stabilization; IEA:Ensembl.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0071076; P:RNA 3' uridylation; IEA:Ensembl.
DR   CDD; cd05402; NT_PAP_TUTase; 1.
DR   Gene3D; 1.10.1410.10; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002058; PAP_assoc.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   InterPro; IPR045862; Trf4-like.
DR   PANTHER; PTHR23092; POLY(A) RNA POLYMERASE; 1.
DR   PANTHER; PTHR23092:SF24; TERMINAL NUCLEOTIDYLTRANSFERASE 4A; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   Pfam; PF03828; PAP_assoc; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          15..123
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          178..237
FT                   /note="PAP-associated"
FT                   /evidence="ECO:0000259|Pfam:PF03828"
FT   REGION          350..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          486..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   542 AA;  59769 MW;  B6849B9A0D3DAA01 CRC64;
     MSPCPEEAAM RREVVKRIET VVKDLWPTAD VQIFGSFSTG LYLPTSDIDL VVFGKWERPP
     LQLLEQALRK HNVAEPCSIK VLDKATVPII KLTDQETEVK VDISFNMETG VRAAEFIKNY
     MKKYSLLPYL ILVLKQFLLQ RDLNEVFTGG ISSYSLILMA ISFLQLHPRI DARRADENLG
     MLLVEFFELY GRNFNYLKTG IRIKEGGAYI AKEEIMKAMT SGYRPSMLCI EDPLLPGNDV
     GRSSYGAMQV KQVFDYAYIV LSHAVSPLAR SYPNRDSEST LGRIIKVTQE VIDYRRWIKE
     KWGSRVHAAP DLDNRIKIKE RVTTCNGEQT QSREPGSPYS QRLTLSLSSP QLLSSGSSAS
     SVSSLSGSDI DSDTPPCTTP SVYQFSLQAP AALMASLPAA LPVPSGKPQS TPSRALIMTT
     NSQTRFTIPP PTLGVAPVPC RQAGVEGTVS LKAVHHVSSP AIPSASPNPL SSPHLYHKQH
     NGMKLSMKGS HSHAQGGGYS SVGSGGVRPP VGNRGHHQYN RTGWRRKKHA HTRDSLPVSL
     SR
//