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Database: UniProt
Entry: I3M4N4_ICTTR
LinkDB: I3M4N4_ICTTR
Original site: I3M4N4_ICTTR 
ID   I3M4N4_ICTTR            Unreviewed;      2342 AA.
AC   I3M4N4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1B {ECO:0000313|Ensembl:ENSSTOP00000004189};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000004189, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000004189}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000004189}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000004189}.
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DR   EMBL; AGTP01090665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01090666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01090667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01090668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01090669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01090670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000004189; -.
DR   Ensembl; ENSSTOT00000004667; ENSSTOP00000004189; ENSSTOG00000004575.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; I3M4N4; -.
DR   OMA; DSPRNNA; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0007269; P:neurotransmitter secretion; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    138    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    171    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    226    248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    303    324       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    336    358       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    514    531       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    552    570       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    613    635       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    691    713       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1160   1178       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1198   1218       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1230   1248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1291   1313       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1403   1428       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1484   1502       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1514   1540       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1607   1625       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1694   1717       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1855   1889       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      716    742       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2342 AA;  262672 MW;  7A1F6802E5D2782C CRC64;
     MVRFGDELGG RYGGAGSGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA QRARTMALYN
     PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPHTPF EYMILATIIA NCIVLALEQH
     LPDGDKTPMS ERLDDTEPYF IGIFCFEAGI KIIALGFAFH KGSYLRNGWN VMDFVVVLTG
     ILATAGTDFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMVPLLQIG LLLFFAILMF
     AIIGLEFYMG KFHKACFPNS SDADPVGDFP CGKEAPARLC EGDTECREYW PGPNFGITNF
     DNILFAILTV FQCITMEGWT DILYNTNDAA GNTWNWLYFI PLIIIGSFFM LNLVLGVLSG
     EFAKERERVE NRRAFLKLRR QQQIERELNG YLEWIFKAEE VMLAEEDKNA EEKSPLDAVL
     KRAATKKSRH DLIHAEEGED RLADLCAVGS PFARASLKSG KTESSSYFRR KEKMFRFFIR
     RMVKAQSFYW VVLCVVALNT LCVAMVHYNQ PQRLTTALYF AEFVFLGLFL TEMSLKMYGL
     GPRSYFRSSF NCFDFGVIVG SIFEVVWAAI KPGTSFGISV LRALRLLRIF KVTKYWNSLR
     NLVVSLLNSM KSIISLLFLL FLFIVVFALL GMQLFGGQFN FKDETPTTNF DTFPAAILTV
     FQILTGEDWN AVMYHGIESQ GGVSKGMFSS FYFIVLTLFG NYTLLNVFLA IAVDNLANAQ
     ELTKDEEEME EAANQKLALQ KAKEVAEVSP MSAANISIAA RQQNSAKARS VWEQRASQLR
     LQNLRASCEA LYSEMDPEER MRYATTRHLR PDMKTHLDRP LVVEPPGRDG PRGPMGGKAR
     PEGTEVTEGV DPPRRHHRHR DRDKVQAVVP AVGEQDRADA VKAESVDPGA REERARPHRS
     RSKDAAGALE SRSERSRGPG PEGGRRHHRR GSPEEAAERE PRRHRAHRHG PEQGKEGVAP
     TAKSERRLRH RGPRAGSREA ESGEEPMRRH RARHKVPSVQ EPTEKEATEK EAAEKEGEMV
     EADKEIRNHH PKEPHCGLEA SGVMGIAPVH VLPSTCLQKV EEQPEDADNQ RNVTRMGIES
     SDPSSTLHVP VTLAGPPGET TVAPSGNLDL ESQAEGKKEA EADDMLRSGP RPIVPYSSMF
     CLSPTNLLRR FCHYIVTMRY FEMVILVVIA LSSIALAAED PVRTDSSRNN ALKYMDYIFT
     GVFTFEMVMK MIDLGLLLHP GAYFRDLWNI LDFIVVSGAL VAFAFSGSKG KDINTIKSLR
     VLRVLRPLKT IKRLPKLKAV FDCVVNSLKN VLNILIVYML FMFIFAVIAV QLFKGKFFYC
     TDESKELERD CRGQYLDYEK EEVEAQPRQW KKYDFHYDNV LWALLTLFTV STGEGWPMVL
     KHSVDATYEE QGPSPGFRME LSIFYVVYFV VFPFFFVNIF VALIIITFQE QGDKVMSECS
     LEKNERACID FAISAKPLTR YMPQNKQSFQ YKTWTFVVSP PFEYFIMAMI ALNTVVLMMK
     FYDAPYEYEL MLKCLNMVFT SMFSLECVLK IIAFGVLNYF RDAWNVFDFV TVLGSITDIL
     VTEIAETNNF INLSFLRLFR AARLVKLLRQ GYTIRILLWT FVQSFKALPY VCLLIAMLFF
     IYAIIGMQVF GNIALDDDTS INRHNNFRTF LQALMLLFRS ATGEAWHEIM LSCLSNRACD
     PDANASECGS DFAYFYFVSF IFLCSFLMLN LFVAVIMDNF EYLTRDSSIL GPHHLDEFIR
     VWAEYDPAAC CRIHYKDMYS LLRCIAPPVG LGKNCPRRLA YKRLVRMNMP ISSEDMTVHF
     TSTLMALIRT ALEIKLAPAG AKQHQCDAEL RKEISSVWAN LPQKTLDLLV PPHKPDEMTV
     GKVYAALMIF DFYKQNKTTR DQIHQAPGGL SQMGPVSLFH PLKATLEQTQ PAVLRGARVF
     LRQKSSTSLS NGGAIQTQES GIKESVSWGT QRTQDALYEA RAPLERGHSA EIPVGQPGTL
     MQNMALRGPD GEPQPGLESQ GRAASMPRLA AETQVSSPEG TPASVVHPAP DASPMKRSIS
     TLAQRSHGGH LCNTTLDRPP PSQAPHHHHH RCHRRRDKKQ RSLEKGSSQH ADTDGGEGPT
     GCRRERERKQ ERGRSQERRQ PSSSSSEKQR FYSCDRFGGR EHPQPKPSLS SHPTSPTAGE
     PGPPPQGSGS INGSPLLSTS GASTPGRGGR RQLPQTPLTP RPSITYKTAN SSPVHFAGAQ
     SGLPAFSPGR LSRGLSEHNA LLQRDPLSQP LAPGSRISSD PYLGQRMDSE ASAHTLPEDT
     LTFEEAVATN SGRSSRTSYV SSLTSQSHPL RRVPNGYHCT LGLGTGSRAR HSYHHPDQDH
     WC
//
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