ID I3M5A5_ICTTR Unreviewed; 1287 AA.
AC I3M5A5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN Name=SMC4 {ECO:0000313|Ensembl:ENSSTOP00000004494.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000004494.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000004494.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC4 subfamily.
CC {ECO:0000256|ARBA:ARBA00006005}.
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DR EMBL; AGTP01097293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005338346.1; XM_005338289.2.
DR STRING; 43179.ENSSTOP00000004494; -.
DR Ensembl; ENSSTOT00000005010.3; ENSSTOP00000004494.2; ENSSTOG00000004993.3.
DR GeneID; 101969153; -.
DR CTD; 10051; -.
DR eggNOG; KOG0996; Eukaryota.
DR GeneTree; ENSGT00900000141094; -.
DR HOGENOM; CLU_001042_4_1_1; -.
DR InParanoid; I3M5A5; -.
DR OMA; CPALDNM; -.
DR OrthoDB; 231904at2759; -.
DR TreeFam; TF101158; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:Ensembl.
DR GO; GO:0000794; C:condensed nuclear chromosome; IEA:Ensembl.
DR GO; GO:0000796; C:condensin complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0051383; P:kinetochore organization; IEA:Ensembl.
DR GO; GO:0010032; P:meiotic chromosome condensation; IEA:Ensembl.
DR GO; GO:0045132; P:meiotic chromosome segregation; IEA:Ensembl.
DR GO; GO:0007076; P:mitotic chromosome condensation; IEA:Ensembl.
DR GO; GO:1905821; P:positive regulation of chromosome condensation; IEA:Ensembl.
DR GO; GO:0051984; P:positive regulation of chromosome segregation; IEA:Ensembl.
DR GO; GO:1905820; P:positive regulation of chromosome separation; IEA:Ensembl.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR18937:SF172; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR18937; STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
DR SUPFAM; SSF57997; Tropomyosin; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 612..727
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 540..574
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 768..844
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 898..1009
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 407..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1287 AA; 146981 MW; 9AAA185773B72070 CRC64;
MPRKGNQPST ARRKEEGPPP SPDGTGSDAE PETPTGRTEN QAEPAETPGE ELDNRSLEEI
LNSIPPPPPP AMTNEAGAPR LMITHIVNQN FKSYAGEKIL GPFHKRFSCI IGPNGSGKSN
VIDSMLFVFG YRAQKIRSKK LSVLIHNSDE HKDIQSCTVE VHFQKIIDKE GDDYEVIPNS
NFYVSRTAYR DNTSVYHISG KKKTFKDVGN LLRSHGIDLD HNRFLILQGE VEQIAMMKPK
GQTEHDEGML EYLEDIIGCG RLNEPIKVLC RRVEILNEHR GEKLNRVKMV EKEKDALEGE
KNIAIEFLTL ENEIFRKKNH VCQYYIYDLR KRIAEMETQK EKIHEDTKEI NEKSNILLNE
MKAKNKAVKD TEKKLNKITK FIEENKEKFT QLDLEDVQVR EKLKHATSKA KKLEKQLQKD
KEKVEELKSV PAKSKNTITE TTTRSNSLEK EKEKEEKKLK EVMDSLKQET QGLQKEKESR
ENELMGFNKS VNEARSKMDV AQSELDIYLS CHNTAVSQLS KAKEALIAAS ETLKERKAAI
GDIQAKLPQT EQELKEKEKE LQKLTQEEIN FKSLVHDLFQ KVEEAKSSLA MNRSRGKVLD
AIIQEKKSGR IPGIYGRLGD LGAIDEKYDV AISSCCQALD YIVVDSIDTA QKCVNFLKRQ
NIGVATFIGL DKMTVWAKKM NKIQTPENTP RLFDLVKVKD EEIRQAFYFA LRDTLVADNL
DQATRLAYQK DKRWRVVTLK GQIIEQSGTM TGGGSKVRKG RMGSSLVMEI SEEEVNKMEL
QLQRDSRKAV EIQEQKVQLE EAVVRLRHNE REMRNTLEKF TASIQRLSEQ EEYLSVQVKE
LQANVLATAP DKKKQKLLEE NVNAFKTEYD DVAEKAGKVE AEVKRLHSLI VEINNHKLQA
QQDKLDKINK QLDECASTIT KAQVAIKTAD RNLKKAQDSI VLTEKEIKDT EKEVSDLTAE
LKSLEDKATE VINNTNAAEK SLPEIQKEHR DLLQELKVIQ ENEHALQKDA LSIKLKLEQI
DGHIAEHNSK IKYWQKEISK ISLHPIEDGP VEEVSVLSQE DLKAIENPDS ITNQIALMEA
QCHEMKPNLG AIAEYKKKEE LYLQRVAELD KITSERDSFR QAYEDLRKQR LNEFMAGFYI
ITNKLKENYQ MLTLGGDAEL ELVDSLDPFS EGIMFSVRPP KKSWKKIFNL SGGEKTLSSL
ALVFALHHYK PTPLYFMDEI DAALDFKNVS IVAFYIYEQT KNAQFIIISL RNNMFEISDR
LIGIYKTYNI TKSVAVNPKE IASKGLC
//
