ID I3M5M9_ICTTR Unreviewed; 1091 AA.
AC I3M5M9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Rho GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00014465};
DE AltName: Full=Rho-type GTPase-activating protein 7 {ECO:0000256|ARBA:ARBA00030675};
DE AltName: Full=START domain-containing protein 12 {ECO:0000256|ARBA:ARBA00032733};
DE AltName: Full=StAR-related lipid transfer protein 12 {ECO:0000256|ARBA:ARBA00030542};
GN Name=DLC1 {ECO:0000313|Ensembl:ENSSTOP00000004667.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000004667.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000004667.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; AGTP01063934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01063935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3M5M9; -.
DR Ensembl; ENSSTOT00000005201.3; ENSSTOP00000004667.3; ENSSTOG00000005190.3.
DR GeneTree; ENSGT00950000183061; -.
DR HOGENOM; CLU_004367_0_0_1; -.
DR TreeFam; TF314044; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04375; RhoGAP_DLC1; 1.
DR CDD; cd09538; SAM_DLC1_2-like; 1.
DR CDD; cd08908; START_STARD12-like; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659:SF2; RHO GTPASE-ACTIVATING PROTEIN 7; 1.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 641..847
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 877..1062
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 159..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1091 AA; 123253 MW; 8E17A22F6A0847C7 CRC64;
MCREKPDTMI LTQIEAKEAC DWLRATGFPQ YAQLYEDLLF PIDITSVKRE HDFLDRDAIE
ALCRRLNTLN KCAVMKLEIS PHRKRSEDSD EDEPCAISGK WTFQRDSKRW SRLEEFDVFS
PKQDPVSGSP DDSHLKNAMS HESMLTDLSE RQEVSSVRSL SSTSSIPTHV SQSGDAVTPR
TNSVISVCSS SHFIGNDDSF CSLPSPKELS SFSFSMKGHE KNAKSKTRSL LKRMESLKLK
GSHHSKHKAP SKLGLIISGP ILQEGMDEEK LKQLNCVEIS ALNGNHINVP MVRKRSVSNS
TQTSSSSSQS ETSSAVSTPS PVTRTRSLSA CNKRVGMYLE GFDPFNQSTF NNVMEQNFKN
RESYPEDTVF YIPEDHKPGT FPKALSNGSF CPSGNNSSVN WRTGSFHGPG HISLRRENSN
DSPKELKRRN SSSSMSSRLS IYDNVPGSIL YSSSGDLADL ENEDIFPELD DILYHVKGMQ
RIVNQWSEKF SDEGDSDSAL DSVSPCPSSP KQIHLDVDND RTTPSDLDST GNSLNEPEEP
SDIPERRDSG VGASLTRCNR HRLRWHSFQS SHRPSLNSVS LQINCQSVAQ MNLLQKYSLL
KLTALLEKYT PSNKHGFSWA VPKFMKRIKV PDYKDRSVFG VPLTVNVQRT GQPLPQSIQQ
AMRYLRNHCL DQVGLFRKSG VKSRIQALRQ MNESATDCVN YEGQSAYDVA DMLKQYFRDL
PEPLMTNKLS ETFLQIYQYV PKDQRLQAIK AAIMLLPDEN REVLQTLLYF LSDVTAAVKE
NQMTPTNLAV CLAPSLFHLN TLKRENSSPR VMQRKQSLGK PDQKDLNENL AATQGLAHMI
AECKKLFQVP EEMSRCRNSY TEQELKPLTL EALGHLSNDE SADYKHFLQD CVDGLYKEVK
EKFKGWVSYS TSEQAELSYK KVSEGPPLRL WRSTIEVPAL PEEILKRLLK EQHLWDVDLL
DSKVIEILDS QTEIYQYVQN SMAPHPARDY VVLRTWRTNL PKGACALLLT SVDHDRAPVA
GVRVNVLLSR YLIEPCGSGK SKLTYMCRAD LRGHMPEWYT KSFGHLCAAE VVKIRDSFIN
QSTETKDTKS R
//
