ID I3M7U1_ICTTR Unreviewed; 1036 AA.
AC I3M7U1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
GN Name=PITRM1 {ECO:0000313|Ensembl:ENSSTOP00000005709.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000005709.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000005709.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC {ECO:0000256|ARBA:ARBA00007575}.
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DR EMBL; AGTP01017010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005320388.1; XM_005320331.2.
DR AlphaFoldDB; I3M7U1; -.
DR STRING; 43179.ENSSTOP00000005709; -.
DR Ensembl; ENSSTOT00000006387.3; ENSSTOP00000005709.3; ENSSTOG00000006348.3.
DR GeneID; 101956820; -.
DR CTD; 10531; -.
DR eggNOG; KOG2019; Eukaryota.
DR GeneTree; ENSGT00390000018381; -.
DR HOGENOM; CLU_009165_0_0_1; -.
DR InParanoid; I3M7U1; -.
DR OrthoDB; 5477696at2759; -.
DR TreeFam; TF300333; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:Ensembl.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR Pfam; PF08367; M16C_assoc; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 504..752
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
FT REGION 803..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..826
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1036 AA; 117778 MW; ED04CD9454CE1BFF CRC64;
MWRCGGRRVR EALQRLRGCS TQHRVWRGMS NPACERALQY KVGEKIHGFT VNQVTSIPEL
FLTAVKLSHD NTGARYLHLA REDTNNVFSV QFRTTPMDST GVPHVLEHTV LCGSQKYPCR
DPFFKMLNRS LSTFMNAFTA SDFTQYPFST QNHKDFQNLL SVYLDATFFP CLRELDFWQE
GWRLEHEDPS DPQTPLIFKG VVFNEMKGAF TDNERIFSQH LQNKILPDHT YSVISGGDPL
CIPELTWEQL KQFHATHYHP SNARFFTYGN FQLEQHLRQI HEEALSKFQK IEPNTAVPAQ
KHWDKPREFQ ITCGPHSLAA NTSKQTMVSV SFLLPDITDT FEAFTLSLLS SLLVAGPNSP
FYKALIESGL GTDFSPDVGY NGNTREAYFS VGLQGIAEKD IQKVRDLVDS TFDEVVEKGF
EDDQIEALLH KIEIQMKHQS TSFGRALISY VASCWNHDGD PVELLQLGNQ LTKFRQCLKE
NPKFLQEKVK QYFMNNQHKL TLSMKPDDKY YEKQTQIETE KLKQKVDSLS PEDKQQIYEK
GLELRSQQSK PQDASCLPAL KVSDIEPSMP FTSLDVALTA GEIPVQYCAQ PTNGLVYFRA
FSSLNTLPEE LRPYVPLFCS VLTKLGCGTL NYRELAQQLE LKTGDMTVSP HVLPDESNPD
TYEQGVLFSS FCLNRNLPDM MHLWSEIFNN PSFEEDEHFK VLVKMTAQEL SNGIPDSGHF
YATLRASRTL TPAGDLQETF SGMNQVRLMK RIAEMTDIKP ILRKFPRIKK HVLNCDNMRC
SVNATPQQMS QAEKEVEKFI RSLGRSKKER KPVRPHVVEK PAHSGSGERA HGNGSQIIRK
LITDPTFKPC QIKTHFQLPF PVYYVGECIR TVPYVHPDHA SLRILARVMT AKFLHTEIRE
KGGAYGGGAK LNYNGIFTFY SYRDPNSIET LQSFEKAIDW AKSGKFTEQD IDEAKLSVFS
AVDAPVAPSD KGMDHFLLGL SDEMKQTHRE QLFAVSHDKL VAVSNEYLGI GKSTHGLAIL
GPEIAKIAKD PSWIIR
//
