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Database: UniProt
Entry: I3M806_ICTTR
LinkDB: I3M806_ICTTR
Original site: I3M806_ICTTR 
ID   I3M806_ICTTR            Unreviewed;       698 AA.
AC   I3M806;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   08-NOV-2023, entry version 60.
DE   SubName: Full=Keratin 2 {ECO:0000313|Ensembl:ENSSTOP00000005803.3};
GN   Name=KRT2 {ECO:0000313|Ensembl:ENSSTOP00000005803.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000005803.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000005803.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; AGTP01037437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01037438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3M806; -.
DR   STRING; 43179.ENSSTOP00000005803; -.
DR   Ensembl; ENSSTOT00000006489.3; ENSSTOP00000005803.3; ENSSTOG00000006467.3.
DR   eggNOG; ENOG502QTM6; Eukaryota.
DR   GeneTree; ENSGT00940000162573; -.
DR   HOGENOM; CLU_012560_6_0_1; -.
DR   InParanoid; I3M806; -.
DR   TreeFam; TF317854; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0001533; C:cornified envelope; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0045095; C:keratin filament; IEA:Ensembl.
DR   GO; GO:0008092; F:cytoskeletal protein binding; IEA:Ensembl.
DR   GO; GO:0030280; F:structural constituent of skin epidermis; IEA:Ensembl.
DR   GO; GO:0045109; P:intermediate filament organization; IEA:Ensembl.
DR   GO; GO:0031424; P:keratinization; IEA:Ensembl.
DR   GO; GO:0032980; P:keratinocyte activation; IEA:Ensembl.
DR   GO; GO:0003334; P:keratinocyte development; IEA:Ensembl.
DR   GO; GO:0051546; P:keratinocyte migration; IEA:Ensembl.
DR   GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR   GO; GO:0045684; P:positive regulation of epidermis development; IEA:Ensembl.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF14; KERATIN, TYPE II CYTOSKELETAL 2 EPIDERMAL; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          197..510
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          144..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          529..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          259..300
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          408..488
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        529..667
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   698 AA;  70059 MW;  0FA1E95E3E578EF4 CRC64;
     MSCQISCRSR RGGSGGGGYR GFSSGSAVVS GASRRSTSGF SCLSRHGGGG GGYGGGGFGS
     RSLVGLGGTK SISISVAGGG GSFGSGGGFG GRGVGFGGGS GFGGGSGFGG GSGFGGGGFG
     GGSGFGGGSG FGGGGFGGGR FGGPGGFGGF GGPGGPGGSG PGGFPGGGIH EVSINESLLQ
     PLNVKVDPEI QNVKSQEREQ IKTLNNKFAS FIDKVRFLEQ QNQVLQTKWE LLQQIDVSSR
     TTHLDPIFQA YISVLKKQVD GLNAERTSQN SELNNMQDLV EDFKKKYEDE INKRTALEND
     FVTLKKDVDS GYTNKVDLQI NVDLLTQEIE FLRTLYEAEV SQLHQTITDT NVILSMDNNR
     SLDLDSIIAE VQAQYEEIAQ RSKDEAEALY HSKYEELQVT AGKHGESLKE FKMEISELNR
     MIQRLQGEIS HVKKQCKSVQ DAIADAEQRG ENALKDAQNK LTELEEALQQ AREDLARLLR
     DYQELMNTKL ALDVEIATYR KLLEGEEYST FCGNILSPAA VTSSSISSSV ASRSGFGGQG
     SGGRGFSSGS SSYGSGGRGS GSRSGGGGGF SSGGGSRGGS SSGGGFSSGG GSRGGSSSGG
     GFRGSRGGSG SGGGFSSGGG SRGGSGSGGG YSSGGGSRGG SSSGGGFSSR GGSSSGGGFS
     SGGGSRGGSG SGGGVSGSEK GGSGSGEGCG SSVTFSFR
//
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