ID I3M806_ICTTR Unreviewed; 698 AA.
AC I3M806;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 08-NOV-2023, entry version 60.
DE SubName: Full=Keratin 2 {ECO:0000313|Ensembl:ENSSTOP00000005803.3};
GN Name=KRT2 {ECO:0000313|Ensembl:ENSSTOP00000005803.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000005803.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000005803.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AGTP01037437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01037438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3M806; -.
DR STRING; 43179.ENSSTOP00000005803; -.
DR Ensembl; ENSSTOT00000006489.3; ENSSTOP00000005803.3; ENSSTOG00000006467.3.
DR eggNOG; ENOG502QTM6; Eukaryota.
DR GeneTree; ENSGT00940000162573; -.
DR HOGENOM; CLU_012560_6_0_1; -.
DR InParanoid; I3M806; -.
DR TreeFam; TF317854; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0001533; C:cornified envelope; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0045095; C:keratin filament; IEA:Ensembl.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:Ensembl.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IEA:Ensembl.
DR GO; GO:0045109; P:intermediate filament organization; IEA:Ensembl.
DR GO; GO:0031424; P:keratinization; IEA:Ensembl.
DR GO; GO:0032980; P:keratinocyte activation; IEA:Ensembl.
DR GO; GO:0003334; P:keratinocyte development; IEA:Ensembl.
DR GO; GO:0051546; P:keratinocyte migration; IEA:Ensembl.
DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0045684; P:positive regulation of epidermis development; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF14; KERATIN, TYPE II CYTOSKELETAL 2 EPIDERMAL; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 197..510
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 144..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 259..300
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 408..488
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 529..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 698 AA; 70059 MW; 0FA1E95E3E578EF4 CRC64;
MSCQISCRSR RGGSGGGGYR GFSSGSAVVS GASRRSTSGF SCLSRHGGGG GGYGGGGFGS
RSLVGLGGTK SISISVAGGG GSFGSGGGFG GRGVGFGGGS GFGGGSGFGG GSGFGGGGFG
GGSGFGGGSG FGGGGFGGGR FGGPGGFGGF GGPGGPGGSG PGGFPGGGIH EVSINESLLQ
PLNVKVDPEI QNVKSQEREQ IKTLNNKFAS FIDKVRFLEQ QNQVLQTKWE LLQQIDVSSR
TTHLDPIFQA YISVLKKQVD GLNAERTSQN SELNNMQDLV EDFKKKYEDE INKRTALEND
FVTLKKDVDS GYTNKVDLQI NVDLLTQEIE FLRTLYEAEV SQLHQTITDT NVILSMDNNR
SLDLDSIIAE VQAQYEEIAQ RSKDEAEALY HSKYEELQVT AGKHGESLKE FKMEISELNR
MIQRLQGEIS HVKKQCKSVQ DAIADAEQRG ENALKDAQNK LTELEEALQQ AREDLARLLR
DYQELMNTKL ALDVEIATYR KLLEGEEYST FCGNILSPAA VTSSSISSSV ASRSGFGGQG
SGGRGFSSGS SSYGSGGRGS GSRSGGGGGF SSGGGSRGGS SSGGGFSSGG GSRGGSSSGG
GFRGSRGGSG SGGGFSSGGG SRGGSGSGGG YSSGGGSRGG SSSGGGFSSR GGSSSGGGFS
SGGGSRGGSG SGGGVSGSEK GGSGSGEGCG SSVTFSFR
//