ID I3M8U7_ICTTR Unreviewed; 456 AA.
AC I3M8U7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 6 {ECO:0000313|Ensembl:ENSSTOP00000006214.3};
GN Name=ENTPD6 {ECO:0000313|Ensembl:ENSSTOP00000006214.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000006214.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000006214.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR EMBL; AGTP01078175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005334644.1; XM_005334587.2.
DR AlphaFoldDB; I3M8U7; -.
DR STRING; 43179.ENSSTOP00000006214; -.
DR Ensembl; ENSSTOT00000006953.3; ENSSTOP00000006214.3; ENSSTOG00000006956.3.
DR GeneID; 101978043; -.
DR CTD; 955; -.
DR eggNOG; KOG1385; Eukaryota.
DR GeneTree; ENSGT01100000263540; -.
DR HOGENOM; CLU_010246_0_2_1; -.
DR InParanoid; I3M8U7; -.
DR OrthoDB; 180318at2759; -.
DR TreeFam; TF315029; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0036384; F:CDP phosphatase activity; IEA:Ensembl.
DR GO; GO:0004382; F:GDP phosphatase activity; IEA:Ensembl.
DR GO; GO:1990003; F:IDP phosphatase activity; IEA:Ensembl.
DR GO; GO:0045134; F:UDP phosphatase activity; IEA:Ensembl.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF99; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 6; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 196
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 226..230
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 456 AA; 50162 MW; AD5177ECFE8F5C36 CRC64;
MRKIPNHGTL RMTKVAYPLG LCLGLFIYVV YIKWHRASAT QAFFTIAGAA SGARWGQQAH
SSLGSAIRGH EVFYGIMFDA GSTGTRVHVF QFAQPPGETP TLTHETFKAL KPGLSAYADD
VEKSAQGIQE LLDVAKQEIP FDFWKVTPLV LKATAGLRLL PGEKAHKLLQ KVKEVFKASP
FLVGDDCVSI MNGTDEGVSA WITVNFLTGS LKTPGRSSVG MLDLGGGSTQ ITFLPRVEGT
LQASPPGHLT ALQMFNRTYK LYSYSYLGLG LMSARLAILG GVEGKPVKDG KDLVSPCLSP
SFKGEWEHAE ITYRISGQKA GSLYELCASR VSEVLRNKVH RTEEVKHVDF YAFSYYYDLA
ASVGLIDAEK GGNLVVEDFE IAAKYVCRTL ETQPHSSPFV CMDLTYITLL LQEFGFPRDK
VLKLTRKIDN VETSWALGAI FHYIDSLNRE KSPALK
//
