ID I3MA76_ICTTR Unreviewed; 493 AA.
AC I3MA76;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Keratin, type II cytoskeletal 74 {ECO:0000313|Ensembl:ENSSTOP00000006869.3};
GN Name=KRT74 {ECO:0000313|Ensembl:ENSSTOP00000006869.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000006869.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000006869.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01037431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01037432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MA76; -.
DR STRING; 43179.ENSSTOP00000006869; -.
DR Ensembl; ENSSTOT00000007682.3; ENSSTOP00000006869.3; ENSSTOG00000031284.1.
DR GeneTree; ENSGT00940000162774; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; I3MA76; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:1990254; F:keratin filament binding; IEA:Ensembl.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:Ensembl.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF5; KERATIN, TYPE II CYTOSKELETAL 74; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 141..379
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 448..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 196..279
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 352..379
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 450..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 54083 MW; 31A8155C9C5EA43F CRC64;
MSRQLNYFKS GGDKGNFSVH SAVVPRKTVG NLASYRTVGQ GAGAGFGSRS LYSLGGNRHI
SFNVAGSGVR AGGYSFGHGS GYGGGRASGF AGSMFGSVAL GPSCASVCLP GGIHQVTVNK
NLLAPLNVEL DPEIQKVRAQ EREQIKALND KFASFIDKVR FLEQQNQVLE TKWELLQQLD
LNNCRKNLEP IYEGHISSLR KQLETLSGDR VRLDSELRNM RDVVEDYKKR YEVEINRRTA
AENEFVVLKK DADAAYTVKV ELQAKVDSLD KDIKFLKCLY DAEIAQIQTH ASETSVILSM
DNNRDLDLDS IIAEVRAHYE DIALKSKAEA EALYQTKIQE LQLAAGRHGD DLKHTRNEMS
ELNRLIQRIR CDITNVKKQV GSYYPDWEDL SLFSHSPSLQ MSQEGLEELT CHGPQLISIG
VRIQVHVSPS VISSSHYGYY GHQPSSVSAD LGAGGASSTR SSQTKTPGAR AGDLKESQGK
SAPASTPARK TTR
//
