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Database: UniProt
Entry: I3MAJ7_ICTTR
LinkDB: I3MAJ7_ICTTR
Original site: I3MAJ7_ICTTR 
ID   I3MAJ7_ICTTR            Unreviewed;      4865 AA.
AC   I3MAJ7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   22-NOV-2017, entry version 39.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSSTOP00000007025};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSSTOP00000007025};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000007025, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000007025}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000007025}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000007025}.
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DR   EMBL; AGTP01091581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000007025; -.
DR   Ensembl; ENSSTOT00000007851; ENSSTOP00000007025; ENSSTOG00000007697.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; I3MAJ7; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 10.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   4865 AA;  551640 MW;  75669CEB751BD4EF CRC64;
     MAEGGEGGED EIQFLRTEDE VVLQCIASIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP
     PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAIL LRHSFSGMYL
     TCLTTSRSQT DKLAFDVGLQ EQATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSISNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD
     QNDSQHRRVF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
     QGLLLQDRGK SDTKSTAFSF RASKEIKEKL DSSHKRDMEG MGVPEIKYGD SICFVQHIAS
     GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ
     FVSGNNRTAA PVTLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG
     MLALVLNCID RLNIYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN
     NLDWLISKLD RLESSSGILE VLHCILIESP EALNLIAEGH IKSIISLLDK HGRNHKVLDV
     LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW
     YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW
     SGRIPRAVAS INQHLLKSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS
     FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGVRDLLGT
     TQFLSQASFI PCPIDTSQVV LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR
     QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEDDLKK VKLPKNYMMS
     NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV
     PYALLDERTK KSNRDSLREA VRTFIGYGYN IEPSDQELAD PAVEKVSIDK IRFFRVERSY
     AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DIELGVDDQA FVFEGSRGQR WHQGSGYFGR
     TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CSLGLSQIGR
     MNLGMDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVVRID
     GTMDSPPCLK VTHKTFGTQN SNANMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI
     LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE
     SVKRSNCYMV WGGDIVASSQ RSSRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN
     TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPVPQCPPRL DVQTIQPVLW
     SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMQFHYH
     TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YTIDNKYLPG LLRSGFYDLL ISIHLANAKE
     RKLMMKNEYI IPITSTTRNI RLYPDESKRH GLPGVGLQTC LKPGFRFSTP CFVVTSEEHQ
     KQSPEIPLEI LKTKALSMLT EAVHCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD
     DDVRQILLLI DPSVFGEHSG ESEEGAEKEE VTQVEEKAVE AGEKTSKEPP IKGLLQTRLP
     ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQVN QKFRYDELMQ ALNMSAALTA
     RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH EDLLAHCGVP WEEEEEEDED
     TTWAGKLCAL VHKIRGPPKQ EKEPPKEEEE RCPTTLKELV SQTMIRWAQE NQIQDAELVR
     MMFNLLRRQY DSIGELLQAL RKTYTISQAS VSDTINLLAA LGQIRSLLSV RMGKEEELLM
     INGLGDIMNN KVFYQHPNLM RVLGMHETVM EVMVNVLGTE KSQIAFPKMV ASCCRFLCYF
     CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL ALGLEEPDLE
     KVVTYLAGCG LQSCPMLVAK GYPDVGWNPI EGERYLSFLR FAVFVNSESV EENASVVVKL
     LIRRPECFGP ALRGEGGNGL LAAMQGAIKI SENPALDLPS QGYKRDVPDE EEEEEEIVHM
     GNAIMSFYSA LIDLLGRCAP EMHLIQTGKG EAIRIRSILR SLVPTEDLVG IISIPLKLPS
     LNKDGSVSEP DMAANFCPDH KAPMVLFLDR VYGIKDQTFL LHLLEVGFLP DLRASASLDT
     VSLSTTESAL ALNRYICSAV LPLLTRCAPL FAGTEHYTSL IDSTLQTIYR LSKGRSLTKA
     QRDTIEECLL AICNHLRPSM LQQLLRRLVF DVPQLNEYCK MPLKLLTNHY EQCWKYYCLP
     SGWGSYGLAV EEELHLTEKL FWGIFDSLSH KKYDPDLFRM ALPCLSAIAG ALPPDYLDTR
     ITATLEKQVS VDADGNFDPK PINTMNFSLP EKLEYIVTKY AEHSHDKWAC DKSQSGWKYG
     ISLDENVKTH PLIRPFKTLT EKEKEIYRWP ARESLKTMLA VGWTVERTKE GEALVQQREN
     EKLRSVSQTS QGNSYSPAPL DLSNVVLSRE LQGMVEVVAE NYHNIWAKKK KLELESKGGG
     SHPLLVPYDT LTAKEKYRDR EKAQDLFKFL QVNGIIVSRG MKDLELDASS MEKRFAYKFL
     KKILKYVDSA QEFIAHLEAI VSSGKTEKSP HDQEIKFFAK VLLPLVDQYF TNHRLYFLSS
     PLKPLSSSGY ASHKEKEMVA SLFCKLAALV RHRISLFGSD STTMVSCLHI LAQTLDTRTV
     MKSGSELVKA GLRAFFENAA EDLEKTSENL KLGKFTHSRT QIKGVSQNIN YTTVALLPIL
     TSIFEHVAQH QFGVDLLLSD VQISCYHILC SLYSLGTGKN IYVERQRPAL GECLASLAAA
     IPVAFLEPTL NRYNPLSVFN TKTPRERSIL GMPDTVEEMC PDIPQLEGLM KEINDLAESG
     ARYTEMPHVI EVILPMLCNY LSYWWERGPE NLPPSTGPCC TKVTSEHLSL ILGNILKIIN
     NNLGIDEASW MKRIAVFAQP IISKARPDLL RSHFIPTLEK LKKKAVKTVQ EEEQLKADGK
     GDTQEAELLI LDEFAVLCRD LYAFYPMLIR YVDNNRSNWL KSPDADSDQL FRMVAEVFIL
     WCKSHNFKRE EQNFVIQNEI NNLAFLTGDS KSKMSKSGGQ DQERKKTKRR GDLYSIQTSL
     IVAALKKMLP IGLNMCTPGD QELISLAKSR YSCRDTDEEV KEHLRNNLHL QEKSDDPAVK
     WQLNLYKDVL RSEEPSNPEK TVERVQRISA AVFHLEQVEQ PLRSKKAVWH KLLSKQRKRA
     VVACFRMAPL YNLPRHRSIN LFLHGYQRFW IETEAYSFEE KLVQDLAKSP KVEEEEEEEM
     EKQPDPLHQI ILHFSRNALT ERSKLEDDPL YTSYSSMMAK SCQSGEDEEE DEDKEKTFEE
     KEMEKQKTLY QQARLHERGA AEMVLQMISA SKGEMSPMVV QTLKLGIAIL NGGNAGVQQK
     MLDYLKEKKD AGFFQSLSGL MQSCSVLDLN AFERQNKAEG LGMVTEEGTL IVRERGEKVL
     QNDEFTRDLF RFLQLLCEGH NSDFQNFLRT QMGNTTTVNI IISTVDYLLR LQESISDFYW
     YYSGKDIIDE SGQHNFSKAL AVTKQIFNSL TEYIQGPCIG NQQSLAHSRL WDAVVGFLHV
     FANMQMKLSQ DSSQIELLKE LLDLLQDMVV MLLSLLEGNV VNGTIGKQMV DTLVESSTNV
     EMILKFFDMF LKLKDLTSSD TFKEYDPDGK GIISKKEFQK AMEGQKQYTQ SEIDFLLSCA
     EADENDMFNY IDFVDRFHEP AKDIGFNVAV LLTNLSEHMP NDSRLKCLLD PAESVLNYFE
     PYLGRIEIMG GAKKIERVYF EISESSRTQW EKPQVKESKR QFIFDVVNEG GEQEKMELFV
     NFCEDTIFEM QLASQISESD SADRPEEEEE ENEDSPYVLE IEGEEEEDRS FESSSAFAMA
     CASAKRNVAN FLKKATVKNL KKQYRNVKKM TAKELVKVFF SFFWMLFVGL FQLFFTILGG
     IFQILWNTVF GGGLVEGAKN IRVTKILGDM PDPTQFGIHD DAVEAEKVEV TEPGIPTELV
     HFVKGEKGDA DIMSDLFGLH PKKEGGLKHG PEVGLGDLSE IIGKDEPPTL ESTVRKKRKA
     QAAEMKAACE AEGKVESEKA DMEDGEKEDK AKEEMQAEDL WAEVTKKKKR RRGQKVEKPE
     ALMANFFKGL EIYQTKLLHY LARNFYNLRF LALFVAFAIN FILLFYKVTE EPLEEETEDV
     ANLWNSFNDE EEEEAMVFFV LQESTGYMAP TLRALAVVHT IISLVCVVGY YCLKVPLVVF
     KREKEIARKL EFDGLYITEQ PSEDDIKGQW DRLVINTPSF PNNYWDKFVK RKVINKYGDL
     YGAERIAELL GLDKNALDFS PVEETKAEAA SLVSWLSSID MKYHIWKLGV VFTDNSFLYL
     AWYTTMSVLG HYNNFFFAAH LLDIAMGFKT LRTILSSVTH NGKQLVLTVG LLAVVVYLYT
     VVAFNFFRKF YNKSEDDDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE DPAGDPYEMY
     RIVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVRE DMETKCFICG IGNDYFDTTP
     HGFETHTLQE HNLANYLFFL MYLINKDETE HTGQESYVWK MYQERCWDFF PAGDCFRKQY
     EDQLG
//
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