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Database: UniProt
Entry: I3MAJ7_ICTTR
LinkDB: I3MAJ7_ICTTR
Original site: I3MAJ7_ICTTR 
ID   I3MAJ7_ICTTR            Unreviewed;      4985 AA.
AC   I3MAJ7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   30-AUG-2017, entry version 37.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSSTOP00000007025};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSSTOP00000007025};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000007025, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000007025}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000007025}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000007025}.
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DR   EMBL; AGTP01091588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01091594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000007025; -.
DR   Ensembl; ENSSTOT00000007851; ENSSTOP00000007025; ENSSTOG00000007697.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; I3MAJ7; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 10.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4272   4296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4504   4523       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4594   4613       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4725   4743       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4786   4807       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4866   4889       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        7     62       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       69    114       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      122    176       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      182    240       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      250    307       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      498    709       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      925   1121       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1247   1463       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4007   4042       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4985 AA;  564964 MW;  2284DF1B0E19C4DA CRC64;
     AAQGGGHRTL LYGHAILLRH SFSGMYLTCL TTSRSQTDKL AFDVGLQEQA TGEACWWTIH
     PASKQRSEGE KVRIGDDLIL VSVSSERYLH LSISNGNIQV DASFMQTLWN VHPTCSGSSI
     EEGYLLGGHV VRLFHGHDEC LTIPSTDQND SQHRRVFYEA GGAGTRARSL WRVEPLRISW
     SGSNIRWGQA FRLRHLTTGH YLALTEDQGL LLQDRGKSDT KSTAFSFRAS KEIKEKLDSS
     HKRDMEGMGV PEIKYGDSIC FVQHIASGLW VTYKAQDAKT SRLGPLKRKV ILHQEGHMDD
     GLTLQRCQRE ESQAARIIRN TTALFSQFVR SREFIYGNNR TAAPVTLPIE EVLQTLQDLI
     AYFQPPEEEM RHEDKQNKLR SLKNRQNLFK EEGMLALVLN CIDRLNIYNS VAHFAGIARE
     ESGMAWKEIL NLLYKLLAAL IRGNRNNCAQ FSNNLDWLIS KLDRLESSSG ILEVLHCILI
     ESPEALNLIA EGHIKSIISL LDKHGRNHKV LDVLCSLCLC NGVAVRANQN LICDNLLPRR
     NLLLQTRLIN DVTSIRPNIF LGVAEGSAQY KKWYFELIID QVDPFLTAEP THLRVGWASS
     SGYAPYPGGG EGWGGNGVGD DLYSYGFDGL HLWSGRIPRA VASINQHLLK SDDVVSCCLD
     LGVPSISFRI NGQPVQGMFE NFNTDGLFFP VMSFSAGVKV RFLMGGRHGE FKFLPPSGYA
     PCYEALLPKE KMRLEPVKEY KRDADGVRDL LGTTQFLSQA SFIPCPIDTS QVVLPPHLEK
     IRDRLAENIH ELWGMNKIEL GWTFGKIRDD NKRQHPCLVE FSKLPETEKN YNLQMSTETL
     KTLLALGCHI AHVNPAAEDD LKKVKLPKNY MMSNGYKPAP LDLSDVKLLP PQEILVDKLA
     ENAHNVWAKD RIKQGWTYGI QQDLKNKRNP RLVPYALLDE RTKKSNRDSL REAVRTFIGY
     GYNIEPSDQE LADPAVEKVS IDKIRFFRVE RSYAVRSGKW YFEFEVVTGG DMRVGWARPG
     CRPDIELGVD DQAFVFEGSR GQRWHQGSGY FGRTWQPGDV VGCMINLDDA SMIFTLNGEL
     LITNKGSELA FADYEIENGF VPICSLGLSQ IGRMNLGMDA STFKFYTMCG LQEGFEPFAV
     NMNRDVAMWF SKRLPTFVNV PKDHPHIEVV RIDGTMDSPP CLKVTHKTFG TQNSNANMIY
     CRLSMPVECH SSFSHVSGSI SLSPKLSNKS SRLREQDNPS EVSLSMKQIS RKEQKCSGSS
     LSEVEDCAIL PCSPGRPGAQ ESQAEKRGIR KQSLYSALSP SPEGPSAPPH TEGLSPLSIV
     PAQQCYYAIR IFAGQDPSCV WVGWVTPDYH LYSEKFDLNK NCTVTVTLGD ERGRVHESVK
     RSNCYMVWGG DIVASSQRSS RSNVDLEIGC LVDLAMGMLS FSANGKELGT CYQVEPNTKV
     FPAVFLQPTS TSLFQFELGK LKNAMPLSAA IFKSEEKNPV PQCPPRLDVQ TIQPVLWSRM
     PNSFLKVETE RVSERHGWVV QCLEPLQMMA LHIPEENRCV DILELCEQED LMQFHYHTLR
     LYSAVCALGN SRVAYALCSH VDLSQLFYTI DNKYLPGLLR SGFYDLLISI HLANAKERKL
     MMKNEYIIPI TSTTRNIRLY PDESKRHGLP GVGLQTCLKP GFRFSTPCFV VTSEEHQKQS
     PEIPLEILKT KALSMLTEAV HCSGAHIRDP VGGSVEFQFV PVLKLIGTLL VMGVFDDDDV
     RQILLLIDPS VFGEHSGESE EGAEKEEVTQ VEEKAVEAGE KTSKEPPIKG LLQTRLPESV
     KLQNDNFCIT GTEKREREMN QLTDYENLPS MALIKRDWMQ GHLTSKPHPQ SLKSAETKAV
     LMQIYSVSTG PGVYLECYLL HKRVHLMLLL QMCELLSYLC DCELQHRVEA IVAFGDIYVS
     KLQVNQKFRY DELMQALNMS AALTARKTKE FRSPPQEQIN MLLNFQLGEN CPCPEEIREE
     LYDFHEDLLA HCGLLGVPWE EEEEEDEDTT WAGKLCALVH KIRGPPKQEK EPPKEEEERC
     PTTLKELVSQ TMIRWAQENQ IQDAELVRMM FNLLRRQYDS IGELLQALRK TYTISQASVS
     DTINLLAALG QIRSLLSVRM GKEEELLMIN GLGDIMNNKV FYQHPNLMRV LGMHETVMEV
     MVNVLGTEKS QIAFPKMVAS CCRFLCYFCR ISRQNQKAMF EHLSYLLENS SVGLASPSMR
     GSTPLDVAAS SVMDNNELAL GLEEPDLEKV VTYLAGCGLQ SCPMLVAKGY PDVGWNPIEG
     ERYLSFLRFA VFVNSESVEE NASVVVKLLI RRPECFGPAL RGEGGNGLLA AMQGAIKISE
     NPALDLPSQG YKRDVPDEEE EEEEIVHMGN AIMSFYSALI DLLGRCAPEM HLIQTGKGEA
     IRIRSILRSL VPTEDLVGII SIPLKLPSLN KDGSVSEPDM AANFCPDHKA PMVLFLDRVY
     GIKDQTFLLH LLEVGFLPDL RASASLDTVS LSTTESALAL NRYICSAVLP LLTRCAPLFA
     GTEHYTSLID STLQTIYRLS KGRSLTKAQR DTIEECLLAI CNHLRPSMLQ QLLRRLVFDV
     PQLNEYCKMP LKLLTNHYEQ CWKYYCLPSG WGSYGLAVEE ELHLTEKLFW GIFDSLSHKK
     YDPDLFRMAL PCLSAIAGAL PPDYLDTRIT ATLEKQVSVD ADGNFDPKPI NTMNFSLPEK
     LEYIVTKYAE HSHDKWACDK SQSGWKYGIS LDENVKTHPL IRPFKTLTEK EKEIYRWPAR
     ESLKTMLAVG WTVERTKEGE ALVQQRENEK LRSVSQTSQG NSYSPAPLDL SNVVLSRELQ
     GMVEVVAENY HNIWAKKKKL ELESKGGGSH PLLVPYDTLT AKEKYRDREK AQDLFKFLQV
     NGIIVSRGMK DLELDASSME KRFAYKFLKK ILKYVDSAQE FIAHLEAIVS SGKTEKSPHD
     QEIKFFAKVL LPLVDQYFTN HRLYFLSSPL KPLSSSGYAS HKEKEMVASL FCKLAALVRH
     RISLFGSDST TMVSCLHILA QTLDTRTVMK SGSELVKAGL RAFFENAAED LEKTSENLKL
     GKFTHSRTQI KGVSQNINYT TVALLPILTS IFEHVAQHQF GVDLLLSDVQ ISCYHILCSL
     YSLGTGKNIY VERQRPALGE CLASLAAAIP VAFLEPTLNR YNPLSVFNTK TPRERSILGM
     PDTVEEMCPD IPQLEGLMKE INDLAESGAR YTEMPHVIEV ILPMLCNYLS YWWERGPENL
     PPSTGPCCTK VTSEHLSLIL GNILKIINNN LGIDEASWMK RIAVFAQPII SKARPDLLRS
     HFIPTLEKLK KKAVKTVQEE EQLKADGKGD TQEAELLILD EFAVLCRDLY AFYPMLIRYV
     DNNRSNWLKS PDADSDQLFR MVAEVFILWC KSHNFKREEQ NFVIQNEINN LAFLTGDSKS
     KMSKKGSCRD QSGGQDQERK KTKRRGDLYS IQTSLIVAAL KKMLPIGLNM CTPGDQELIS
     LAKSRYSCRD TDEEVKEHLR NNLHLQEKSD DPAVKWQLNL YKDVLRSEEP SNPEKTVERV
     QRISAAVFHL EQVEQPLRSK KAVWHKLLSK QRKRAVVACF RMAPLYNLPR HRSINLFLHG
     YQRFWIETEA YSFEEKLVQD LAKSPKVEEE EEEEMEKQPD PLHQIILHFS RNALTERSKL
     EDDPLYTSYS SMMAKAYGSC HSGEDEEEDE DKEKTFEEKE MEKQKTLYQQ ARLHERGAAE
     MVLQMISASK GEMSPMVVQT LKLGIAILNG GNAGVQQKML DYLKEKKDAG FFQSLSGLMQ
     SCSVLDLNAF ERQNKAEGLG MVTEEGTREK VLQNDEFTRD LFRFLQLLCE GHNSDFQNFL
     RTQMGNTTTV NIIISTVDYL LRLQESISDF YWYYSGKDII DESGQHNFSK ALAVTKQIFN
     SLTEYIQGPC IGNQQSLAHS RLWDAVVGFL HVFANMQMKL SQSKDSSQIE LLKELLDLLQ
     DMVVMLLSLL EGNVVNGTIG KQMVDTLVES STNVEMILKF FDMFLKLKDL TSSDTFKEYD
     PDGKGIISKK EFQKAMEGQK QYTQSEIDFL LSCAEADEND MFNYIDFVDR FHEPAKDIGF
     NVAVLLTNLS EHMPNDSRLK CLLDPAESVL NYFEPYLGRI EIMGGAKKIE RVYFEISESS
     RTQWEKPQVK ESKRQFIFDV VNEGGEQEKM ELFVNFCEDT IFEMQLASQI SESDSADRPE
     EEEEENEDSP YVLEIEGEEE EDRSFESSSA FAMACASAKR NVANFLKKAT VKNLKKQYRN
     VKKMTAKELV KVFFSFFWML FVGLFQLFFT ILGGIFQILW NTVFGGGLVE GAKNIRVTKI
     LGDMPDPTQF GIHDDAVEAE KVEVTEPGIP TELVHFVKGE KGDADIMSDL FGLHPKKEGG
     LKHGPEVGLG DLSEIIGKDE PPTLESTVRK KRKAQAAEMK AACEAEGKVE SEKADMEDGE
     KEDKAKEEMQ AEDLWAEVTK KKKRRRGQKV EKPEALMANF FKGLEIYQTK LLHYLARNFY
     NLRFLALFVA FAINFILLFY KILNSKPPDN LLWPRAIIQD TGIFLGQVTE EPLEEETEDV
     ANLWNSFNDE EEEEAMVFFV LQESTGYMAP TLRALAVVHT IISLVCVVGY YCLKVPLVVF
     KREKEIARKL EFDGLYITEQ PSEDDIKGQW DRLVINTPSF PNNYWDKFVK RKVINKYGDL
     YGAERIAELL GLDKNALDFS PVEETKAEAA SLVSWLSSID MKYHIWKLGV VFTDNSFLYL
     AWYTTMSVLG HYNNFFFAAH LLDIAMGFKT LRTILSSVTH NGKQLVLTVG LLAVVVYLYT
     VVAFNFFRKF YNKSEDDDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE DPAGDPYEMY
     RIVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVRE DMETKCFICG IGNDYFDTTP
     HGFETHTLQE HNLANYLFFL MYLINKDETE HTGQESYVWK MYQERCWDFF PAGDCFRKQY
     EDQLG
//
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