ID I3MDR6_ICTTR Unreviewed; 1677 AA.
AC I3MDR6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Cullin 7 {ECO:0000313|Ensembl:ENSSTOP00000008566.3};
GN Name=CUL7 {ECO:0000313|Ensembl:ENSSTOP00000008566.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000008566.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000008566.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR EMBL; AGTP01010823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 43179.ENSSTOP00000008566; -.
DR Ensembl; ENSSTOT00000009550.3; ENSSTOP00000008566.3; ENSSTOG00000009522.3.
DR eggNOG; ENOG502RDJD; Eukaryota.
DR GeneTree; ENSGT00940000153954; -.
DR HOGENOM; CLU_001067_1_0_1; -.
DR InParanoid; I3MDR6; -.
DR TreeFam; TF101154; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:1990393; C:3M complex; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0031467; C:Cul7-RING ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:Ensembl.
DR GO; GO:0001890; P:placenta development; IEA:Ensembl.
DR GO; GO:0050775; P:positive regulation of dendrite morphogenesis; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0007088; P:regulation of mitotic nuclear division; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021097; CPH_domain.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22771; CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22771:SF3; CULLIN-7; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF11515; Cul7; 1.
DR Pfam; PF00888; Cullin; 1.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
DR PROSITE; PS51284; DOC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 795..974
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 1196..1485
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 1325..1348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1677 AA; 189103 MW; 3B6EAD188CFE5829 CRC64;
MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDD GEGASSQVDC
KAEHILLWMS DDEIYANCHK MLGEDGQVIG PSRESAEAGA LDKTVLGEME TDVKSLIQRA
LRQLEECVGT MPPAPLLHTV HVLSAYASIE PLTGVFKDPR VLDLLMHMLS SPDYQVRWSA
GRMIQALSSH DAGTRTQILL SLSQQEAIEK HLDFDSRCAL LALFAQATLS EHPMSFEGIQ
LPQVPGRLLF SLVKRYLHVT FLLDQLNDSA GEPGAQNNSA PEELSGERGR LELEFSMAMG
TLISELVQAM RWDWATSRPG SLARSPCSIF QPQPADASPG HLSTQAQRSF RRSRRFRPRS
EFASGNTYAL YVRDMLQPGM RVRMLDDYEE ISVGDEGEFR QSNSGVPPAQ VLWESTGRTY
WVHWHMLEIL GFEEDIEDTV EADEYQGAVI SRVLGGALPS WRWKPMTELY AVPYVLPEDE
DAEESEHLTQ AEWWELLFFI KKLDGPDYQE VFQILQDNLE GEHVLDEEIL AELAVPMELA
QDLLLSLPQR LDDSALRDLL NCRVYRKYGP EALAGQPAYP SFLEAQQDVL KEPPPQSPSA
SLQSLVEGLG PAGKLLVDLE RALNSEGPRE REVKPCLLQL QRQPQPFLAL MQTLDTPATN
KALHLTALKI LTQLVDFPEA LLLPWHEAMD ACMTCLRSPN TDREVLQELI TFLHRLTSAS
RDYAVVLNQL GARDAISKAL EKHLGKLELA QELRDMVFKC EKHAHLYRKL TTNILGGCIQ
MVLGQIEDHR RTHRPINIPF FDVFLRYLCQ GSSVDVKEDK CWEKVEVSSN PHRASKLTDR
NPKTYWESNG SAGSHSITLY MRQGILIRQL TVLVAGEDSS YMPARLVVCG GDSVNSLNTE
LNSVNVMPYA SRVTLLENLT RFWPIIQIRI KRCQQGGIDT RIRGLEVLGP KPTFWPVFRE
QLCRHTRLFY MVRAQAWSQD IAEDRRSLLH LSSRLNGALR QEQNFADHFL PDDEAAQALG
KTCWEALVSP LVQNITSPDE DGISPLGWLL DQYLECREAS HNPQSRAAAF SSRVRRLTHL
LVHVEPCEMA PPVVAAPRPK GRNRSHDWSS LATRGLPSSI MRNLTRCWQA VVEEQVNNFL
TSYWRDNDFV PRYCEHYYNL QKSSSELFGP RAAFLLALQN GCAGALLRLS FLRAAHVSEQ
FARHIDQRIQ GSRIGGARGM EMLAQLQRCL ETVLNFSGLE IATTFEHYYQ QYMADRLLGV
GSSWLEGAVL EQIGPCFPNR LPQQMLRSLS TSEELQRQFH VYQLQQLDQE LLKLEDTEKK
IQVGHEASGK EHKNGKEEDA GEAVAADVVE GEEEENEDLY YEGAMPEVSV LVLSPRCWPV
ASICHMLNPG TCLPSYLRGT LNRYSNFYNK SQRHPALERG SQRQLQWTWL GRAEVQFGDQ
TLHVSTMQMW LLLNLNNLKA VSVESLLALS GLPLEMLNQA IGPLTSSRGP LDLQEQKDVP
GGVLKIRDDS EEPRPRRGNV WLIPPQTYMK AEDEEGRNLE KRRNLLNCLV VRILKAHGDE
GLHIDQLVCL VLEAWQKGPC PPRGLVSSLG RGAACSSTDV LSCILHLLGK GTLRRHDDRP
QMLSYAVPVT VMEPHTESLN PGSSGPNPPL TFHTLQIRSR GVPYASCTGT QSFSTFR
//
