GenomeNet

Database: UniProt
Entry: I3MEC0_ICTTR
LinkDB: I3MEC0_ICTTR
Original site: I3MEC0_ICTTR 
ID   I3MEC0_ICTTR            Unreviewed;       563 AA.
AC   I3MEC0;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE            EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE   AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE   AltName: Full=3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit {ECO:0000256|ARBA:ARBA00031109};
DE   AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
GN   Name=MCCC2 {ECO:0000313|Ensembl:ENSSTOP00000008827.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000008827.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000008827.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC         methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC         Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC         ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00029358};
CC   -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC       3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC       {ECO:0000256|ARBA:ARBA00025711}.
CC   -!- SIMILARITY: Belongs to the AccD/PCCB family.
CC       {ECO:0000256|ARBA:ARBA00006102}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AGTP01055289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01055290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01055291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005329024.1; XM_005328967.1.
DR   AlphaFoldDB; I3MEC0; -.
DR   STRING; 43179.ENSSTOP00000008827; -.
DR   Ensembl; ENSSTOT00000009842.3; ENSSTOP00000008827.3; ENSSTOG00000009830.3.
DR   GeneID; 101965547; -.
DR   CTD; 64087; -.
DR   eggNOG; KOG0540; Eukaryota.
DR   GeneTree; ENSGT00940000155949; -.
DR   HOGENOM; CLU_018822_0_0_1; -.
DR   InParanoid; I3MEC0; -.
DR   OrthoDB; 5474505at2759; -.
DR   TreeFam; TF300446; -.
DR   UniPathway; UPA00363; UER00861.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0002169; C:3-methylcrotonyl-CoA carboxylase complex, mitochondrial; IEA:Ensembl.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR   GO; GO:0004485; F:methylcrotonoyl-CoA carboxylase activity; IEA:Ensembl.
DR   GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR034733; AcCoA_carboxyl_beta.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR011763; COA_CT_C.
DR   InterPro; IPR011762; COA_CT_N.
DR   InterPro; IPR045190; MCCB/AccD1-like.
DR   PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR   PANTHER; PTHR22855:SF13; METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL; 1.
DR   Pfam; PF01039; Carboxyl_trans; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 2.
DR   PROSITE; PS50989; COA_CT_CTER; 1.
DR   PROSITE; PS50980; COA_CT_NTER; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          49..306
FT                   /note="CoA carboxyltransferase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50980"
FT   DOMAIN          309..555
FT                   /note="CoA carboxyltransferase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50989"
SQ   SEQUENCE   563 AA;  61164 MW;  605038760A57E8DF CRC64;
     MWAPLRSALR PCFRAAAPGL RAYHGDAVAA LGTQLDSGSA IYQENYEQMK ALVDQLHERA
     QYIRLGGSEK ARALHTARGK LLPRERVDTL IDPGSPFLEL SQFAGYQLYG NEDVPAGGII
     TGIGRVSGVE CMIVANDATV KGGSYYPVTV KKHLRAQEIA MQNRLPCIYL VDSGGANLPR
     QADVFPDRDH FGRIFYNQAI MSSKGITQIA VVLGSCTAGG AYVPAMADEN IIVRKQGTIF
     LAGPPLVKAA TGEEVSAEDL GGADLHCRKS GVTDHYALND HHALHLTRKV VRSLNYQKKL
     DVTIEPSEEP LFPADEMYGI VGANLKRNFD IREVIARIVD GSRFNEFKAF YGDTLVTGFA
     RIFGYPIGII GNNGVLFSES AKKGAHFIQL CCQRNIPLLF LQNITGFMVG REYEAEGIAK
     DGAKMVAAVA CANVPKITVI IGGSYGAGNY GMCGRAYSPR FLYMWPNARI SVMGGEQAAN
     VLATIAKDQK AREGKQLSSA DEAALKEPVI KRFEEEGNPY YSSARLWDDG IIDPVDTRLV
     LGLSISAALN APIQKTDFGV FRM
//
DBGET integrated database retrieval system