ID I3MEC0_ICTTR Unreviewed; 563 AA.
AC I3MEC0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit {ECO:0000256|ARBA:ARBA00031109};
DE AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
GN Name=MCCC2 {ECO:0000313|Ensembl:ENSSTOP00000008827.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000008827.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000008827.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00029358};
CC -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC {ECO:0000256|ARBA:ARBA00025711}.
CC -!- SIMILARITY: Belongs to the AccD/PCCB family.
CC {ECO:0000256|ARBA:ARBA00006102}.
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DR EMBL; AGTP01055289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01055290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01055291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005329024.1; XM_005328967.1.
DR AlphaFoldDB; I3MEC0; -.
DR STRING; 43179.ENSSTOP00000008827; -.
DR Ensembl; ENSSTOT00000009842.3; ENSSTOP00000008827.3; ENSSTOG00000009830.3.
DR GeneID; 101965547; -.
DR CTD; 64087; -.
DR eggNOG; KOG0540; Eukaryota.
DR GeneTree; ENSGT00940000155949; -.
DR HOGENOM; CLU_018822_0_0_1; -.
DR InParanoid; I3MEC0; -.
DR OrthoDB; 5474505at2759; -.
DR TreeFam; TF300446; -.
DR UniPathway; UPA00363; UER00861.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0002169; C:3-methylcrotonyl-CoA carboxylase complex, mitochondrial; IEA:Ensembl.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0004485; F:methylcrotonoyl-CoA carboxylase activity; IEA:Ensembl.
DR GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR045190; MCCB/AccD1-like.
DR PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR22855:SF13; METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 49..306
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 309..555
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 563 AA; 61164 MW; 605038760A57E8DF CRC64;
MWAPLRSALR PCFRAAAPGL RAYHGDAVAA LGTQLDSGSA IYQENYEQMK ALVDQLHERA
QYIRLGGSEK ARALHTARGK LLPRERVDTL IDPGSPFLEL SQFAGYQLYG NEDVPAGGII
TGIGRVSGVE CMIVANDATV KGGSYYPVTV KKHLRAQEIA MQNRLPCIYL VDSGGANLPR
QADVFPDRDH FGRIFYNQAI MSSKGITQIA VVLGSCTAGG AYVPAMADEN IIVRKQGTIF
LAGPPLVKAA TGEEVSAEDL GGADLHCRKS GVTDHYALND HHALHLTRKV VRSLNYQKKL
DVTIEPSEEP LFPADEMYGI VGANLKRNFD IREVIARIVD GSRFNEFKAF YGDTLVTGFA
RIFGYPIGII GNNGVLFSES AKKGAHFIQL CCQRNIPLLF LQNITGFMVG REYEAEGIAK
DGAKMVAAVA CANVPKITVI IGGSYGAGNY GMCGRAYSPR FLYMWPNARI SVMGGEQAAN
VLATIAKDQK AREGKQLSSA DEAALKEPVI KRFEEEGNPY YSSARLWDDG IIDPVDTRLV
LGLSISAALN APIQKTDFGV FRM
//