ID I3MFS0_ICTTR Unreviewed; 376 AA.
AC I3MFS0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Hydroxylysine kinase {ECO:0000256|ARBA:ARBA00040505};
DE EC=2.7.1.81 {ECO:0000256|ARBA:ARBA00038873};
GN Name=HYKK {ECO:0000313|Ensembl:ENSSTOP00000009494.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000009494.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000009494.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-
CC lysine. {ECO:0000256|ARBA:ARBA00037368}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine +
CC GDP + H(+); Xref=Rhea:RHEA:19049, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:37565, ChEBI:CHEBI:57882, ChEBI:CHEBI:58189,
CC ChEBI:CHEBI:58357; EC=2.7.1.81;
CC Evidence={ECO:0000256|ARBA:ARBA00036820};
CC -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC {ECO:0000256|ARBA:ARBA00006219}.
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DR EMBL; AGTP01003646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01003647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01003648; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005316907.1; XM_005316850.2.
DR AlphaFoldDB; I3MFS0; -.
DR STRING; 43179.ENSSTOP00000009494; -.
DR Ensembl; ENSSTOT00000010578.3; ENSSTOP00000009494.2; ENSSTOG00000010580.3.
DR GeneID; 101958342; -.
DR CTD; 123688; -.
DR eggNOG; ENOG502QT7T; Eukaryota.
DR GeneTree; ENSGT00390000011314; -.
DR HOGENOM; CLU_042971_1_1_1; -.
DR InParanoid; I3MFS0; -.
DR OMA; AAHSCQL; -.
DR OrthoDB; 5398335at2759; -.
DR TreeFam; TF324471; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0047992; F:hydroxylysine kinase activity; IEA:Ensembl.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR21064:SF1; HYDROXYLYSINE KINASE; 1.
DR PANTHER; PTHR21064; UNCHARACTERIZED; 1.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 37..281
FT /note="Aminoglycoside phosphotransferase"
FT /evidence="ECO:0000259|Pfam:PF01636"
SQ SEQUENCE 376 AA; 42256 MW; 9CBF7DC50CBC9922 CRC64;
MSSGDDEQSQ ALAKPTFTEV QASAVVESVF GLKVSKIQPL PSYDDQNFHV HISKIKDTTD
GPIEYVLKIS NTEASKNPDL IEVQNHIIMF LKAAGFPTAS VCRTKGDNTT SLMSIDSGTE
IKSYLVRLLT YLPGKPIAKI PVSTQLLYEI GRLAAKLDKA LEKFHHPKLS NLHRENFIWN
LKNIPLLEKY VDALGQNQNR EIVEQVIQLF KKEVMTKLSH FRECINHGDL NDHNILVESS
KSAFGDAVYQ VSGILDFGDM SYGYYVFEVA ITIMYMMIES KNPIQVGGHI LAGFESIIPL
TAVERSALFL LVCSRFCQSL VMAAYSCQLH PENKEYLMIT AKTGWKHLQQ MFDMGQKAVE
EIWFETAKSY ESGISL
//
