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Database: UniProt
Entry: I3MGP1_ICTTR
LinkDB: I3MGP1_ICTTR
Original site: I3MGP1_ICTTR 
ID   I3MGP1_ICTTR            Unreviewed;      1684 AA.
AC   I3MGP1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   07-JUN-2017, entry version 39.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSSTOP00000009956};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000009956, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000009956}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000009956}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000009956}.
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DR   EMBL; AGTP01000226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000009956; -.
DR   Ensembl; ENSSTOT00000011098; ENSSTOP00000009956; ENSSTOG00000011072.
DR   eggNOG; ENOG410INF4; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; I3MGP1; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF269; PTHR10037:SF269; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    121    142       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    154    179       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    239    261       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    371    399       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    507    524       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    536    558       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    631    650       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    707    729       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    936    955       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    976    995       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1001   1018       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1061   1082       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1171   1195       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1245   1272       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1284   1302       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1309   1333       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1371   1399       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1475   1501       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1515   1550       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   1684 AA;  194296 MW;  1F081AEEA06DF7C5 CRC64;
     MLDSTEPKGL VPFTEESLKL IKQHIAKKHN EEHEEDDLKP DSALEVGKKL PFIYGELSRG
     MVSEPLEDVD SYYYVKKNTF MVLNKKRTIF RFNAASILCT LSPFSPIRGT TIKVLVHPLT
     FFRLLILISV LTDCIFMTMT NWSIWITAIE NTLLGIYTFE ILVKIIARGF WAGSFSFLAD
     PWNWLDFGVT LFEIITRYSP LNFVLNLKTV RTLRILKIIP LNQGLKSLVE TLIQCLKKLF
     GAIILTLFFL SVFSLIGMGL FMGNLKHKCL RWPQEDENET LHNRTGNPYY IRETENFYYL
     EGERYALLCG NTTDAGQCPE GYVCVKAGLN PDLGYTNFDN FGWALLALFR LMTQDYPEAL
     YHQILYASGK IYMIFFVVVS FWFAFYLASL FLGILAMAYE EGKHATDEKS KKEPTFQQPI
     SKLQEGSEEA ESKTTQIEMK KRSPASMNTS LDVLEEDTLR HKEELKKSRK KCPLCWYRFS
     KFFLIWNCSP CWLKLKEFVH RLITDPFTDL FLLICIILNI YFLAWEHYPM SDDHSYLLSI
     GNLVFLGIFT AEMIFKIIAM NPYWYFQVGW NIFDSLIVLQ GLAELYLANI EGLALCQSFR
     MLRVFKLGKY WPTFEILMLT LGNSLSALKD LILLLFTFIF FSAVFGMKLF GWSYKACVCR
     IDENCQLPRW HMHDFFHSCL NVFRILCGEW IETLWDCMEV AGQPWCISFY MMVILIGNLL
     VLYLFLALVS SFSSYKDSTS EENNEVKNIQ LAMARIKKGV NYVLHKILCK KQNVPQETTD
     HVNDTYVKEN ISDHTLSEFS NTQVFLKDKE KSSGTEKNTM TDNESQSLIP SPSVSETVPI
     ASGESDVENL DNKEIQSKSG NGDSRDKIKQ SSSSECSTVD IAISEEEEMV YECEKAKYLK
     NGFEQRSSPG QISRVSKKAK IWQNIRKTCC KIVENSWFRC FIGLVTLLST GALAFEDIYI
     DQRKTIKILL EYADMIFTYI FILEMLLKWM AYGFKAYFSN GWYKLDFMVV IVFCLSLLGK
     TREDLKPLTS IKFLRALRVL SQFERMKVVV RGLIKTILPT LNVFLVCLMI WLIFSIMGVH
     LFSGTFYECI DPTSEERFPV SEVVNRSQCE NLVLNESMPW ENAKLNFDNV GNGFLSLLQV
     ATFNGWITIM NSAIDSVGVN MQPDFEYNLY IYYYFISFII LGLFLPLSML ISVIITNFNK
     HKIKQGGSNI FITVKQRKQY RKLKRLMYED SPRPLPRPRN KFQGFVFDLV TNQVFNIIIM
     VLIHVQAVTI MIQSDEQSQQ MDIAVYWINA IFVILYTLEC ILKLISFHCY YFTIIWNVFD
     FVVVIFSITG LFLPMTIGYY LVPPSLVQLI LLSRIIHVLR LGKGPRVFHN LMLPLMLSLP
     ALLNIGLFIF LVMFIYAIFG MYNFAYVKKE AGINDVSNFE TFGSSMLCLF QVTIFAGWDG
     MLNAIFNSKW SDCDPDKINP GTQVRGDCGN PSVGIFYFVS YILISWLVIV NMYIVVVMEF
     LSIVSKKKSR TLSEDDFRKF FQVWKRFDPD RTQYIDSSQL SDFAAALDPP LFMAKPNKGQ
     LIAMDLPMAV GDRIHCLDIL LAFTKRVMGK DARVEKLLSE VESGFVLANP FKITYEPITT
     TLKRKQEAVS ATIIQRAYKS YRLRQNDKNT SDIHIIDGDR DVQATKEGVY FDKAKEKSTI
     QSQI
//
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