GenomeNet

Database: UniProt
Entry: I3MGP1_ICTTR
LinkDB: I3MGP1_ICTTR
Original site: I3MGP1_ICTTR 
ID   I3MGP1_ICTTR            Unreviewed;      1681 AA.
AC   I3MGP1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   22-NOV-2017, entry version 41.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSSTOP00000009956};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000009956, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000009956}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000009956}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000009956}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTP01000226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000009956; -.
DR   Ensembl; ENSSTOT00000011098; ENSSTOP00000009956; ENSSTOG00000011072.
DR   eggNOG; ENOG410INF4; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; I3MGP1; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF14; PTHR10037:SF14; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
SQ   SEQUENCE   1681 AA;  194047 MW;  892A503567C35620 CRC64;
     MLDSTEPKGL VPFTEESLKL IKQHIAKKHN EEHEEDDLKP DSALEVGKKL PFIYGELSRG
     MVSEPLEDVD SYYYVKKNTF MVLNKKRTIF RFNAASILCT LSPFSPIRGT TIKVLLTFFR
     LLILISVLTD CIFMTMTNWS IWITAIENTL LGIYTFEILV KIIARGFWAG SFSFLADPWN
     WLDFGVTLFE IITRYSPLNF VLNLKTVRTL RILKIIPLNQ GLKSLVETLI QCLKKLFGAI
     ILTLFFLSVF SLIGMGLFMG NLKHKCLRWP QEDENETLHN RTGNPYYIRE TENFYYLEGE
     RYALLCGNTT DAGQCPEGYV CVKAGLNPDL GYTNFDNFGW ALLALFRLMT QDYPEALYHQ
     ILYASGKIYM IFFVVVSFWF AFYLASLFLG ILAMAYEEGK HATDEKSKKE PTFQQPISKL
     QEGSEEAESK TTQIEMKKRS PASMNTSLDV LEEDTLRHKE ELKKSRKKCP LCWYRFSKFF
     LIWNCSPCWL KLKEFVHRLI TDPFTDLFLL ICIILNIYFL AWEHYPMSDD HSYLLSIGNL
     VFLGIFTAEM IFKIIAMNPY WYFQVGWNIF DSLIVLQGLA ELYLANIEGL ALCQSFRMLR
     VFKLGKYWPT FEILMLTLGN SLSALKDLIL LLFTFIFFSA VFGMKLFGWS YKACVCRIDE
     NCQLPRWHMH DFFHSCLNVF RILCGEWIET LWDCMEVAGQ PWCISFYMMV ILIGNLLVLY
     LFLALVSSFS SYKDSTSEEN NEVKNIQLAM ARIKKGVNYV LHKILCKKQN VPQETTDHVN
     DTYVKENISD HTLSEFSNTQ VFLKDKEKSS GTEKNTMTDN ESQSLIPSPS VSETVPIASG
     ESDVENLDNK EIQSKSGNGD SRDKIKQSSS SECSTVDIAI SEEEEMVYEC EKAKYLKNGF
     EQRSSPGQIS RVSKKAKIWQ NIRKTCCKIV ENSWFRCFIG LVTLLSTGAL AFEDIYIDQR
     KTIKILLEYA DMIFTYIFIL EMLLKWMAYG FKAYFSNGWY KLDFMVVIVF CLSLLGKTRE
     DLKPLTSIKF LRALRVLSQF ERMKVVVRGL IKTILPTLNV FLVCLMIWLI FSIMGVHLFS
     GTFYECIDPT SEERFPVSEV VNRSQCENLV LNESMPWENA KLNFDNVGNG FLSLLQVATF
     NGWITIMNSA IDSVGVNMQP DFEYNLYIYY YFISFIILGL FLPLSMLISV IITNFNKHKI
     KIRGSNIFIT VKQRKQYRKL KRLMYEDSPR PLPRPRNKFQ GFVFDLVTNQ VFNIIIMVLI
     HVQAVTIMIQ SDEQSQQMDI AVYWINAIFV ILYTLECILK LISFHCYYFT IIWNVFDFVV
     VIFSITGLFL PMTIGYYLVP PSLVQLILLS RIIHVLRLGK GPRVFHNLML PLMLSLPALL
     NIGLFIFLVM FIYAIFGMYN FAYVKKEAGI NDVSNFETFG SSMLCLFQVT IFAGWDGMLN
     AIFNSKWSDC DPDKINPGTQ VRGDCGNPSV GIFYFVSYIL ISWLVIVNMY IVVVMEFLSI
     VSKKKSRTLS EDDFRKFFQV WKRFDPDRTQ YIDSSQLSDF AAALDPPLFM AKPNKGQLIA
     MDLPMAVGDR IHCLDILLAF TKRVMGKDAR VEKLLSEVES GFVLANPFKI TYEPITTTLK
     RKQEAVSATI IQRAYKSYRL RQNDKNTSDI HIIDGDRDVQ ATKEGVYFDK AKEKSTIQSQ
     I
//
DBGET integrated database retrieval system