ID I3MGQ2_ICTTR Unreviewed; 705 AA.
AC I3MGQ2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=DIX domain containing 1 {ECO:0000313|Ensembl:ENSSTOP00000009973.3};
GN Name=DIXDC1 {ECO:0000313|Ensembl:ENSSTOP00000009973.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000009973.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000009973.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01076251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MGQ2; -.
DR STRING; 43179.ENSSTOP00000009973; -.
DR Ensembl; ENSSTOT00000011118.3; ENSSTOP00000009973.3; ENSSTOG00000011111.3.
DR eggNOG; ENOG502RD5G; Eukaryota.
DR GeneTree; ENSGT00950000182903; -.
DR HOGENOM; CLU_025678_0_0_1; -.
DR InParanoid; I3MGQ2; -.
DR TreeFam; TF318198; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0021799; P:cerebral cortex radially oriented cell migration; IEA:Ensembl.
DR GO; GO:0021869; P:forebrain ventricular zone progenitor cell division; IEA:Ensembl.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:Ensembl.
DR CDD; cd21213; CH_DIXDC1; 1.
DR Gene3D; 2.40.240.130; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR015506; Dsh/Dvl-rel.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10878:SF22; DIXIN; 1.
DR PANTHER; PTHR10878; SEGMENT POLARITY PROTEIN DISHEVELLED; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00778; DIX; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00021; DAX; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50841; DIX; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW ProRule:PRU00069}.
FT DOMAIN 20..147
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 622..702
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT REGION 227..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 301..328
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 363..481
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 227..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 80024 MW; EBFB42BF933958FE CRC64;
MLACLTRGNL LDVLQEGFNE QQLQAYVAWV NAQLKKRPSV RPVQDLRQDL RDGVILAYLI
EIVGQLALDS YVTIFILHMP FDTAGEKLSG VQLSPSNQQE MKNNVEKVLQ FVASKKIRMH
QTSAKDIVEG NLKSIMRLVL ALAAHFKPGS SRMVSQGQDS RAPLQSHQPH CATAVAQGAA
AALADVCHDM SRSGRDVFRY RQRNSSMDEE IENPYWSVRA LVQQYEGQQR SPSESSCSSL
TSPSPIHSAK SESIITQSEE KADFVIIPSE GIENRTEEID SPLSRDWRPG SPRTYLETSW
EEQLLEQQEH LEKEMEEAKK MISGLQALLL NGSLPEDEQE RPLALCEPGA NPEEQLVIIQ
SRLDQSMVEN QDLKKELLKC KQEARNLQGI KDALQQRLTQ QDTAVLQLKQ ELLRANMDKD
ELQNQNVDLQ RKLDERNRLL GEYKKELGQK DRLLQQHQVK LEEALRKLSD ASHQQVDLER
ELEHKDVLLA HCMKREVDEV TNYNSHNSQS NGFLLPTAGK GAASITHRGP QTSDLQLVRD
ALRSLRNSFS GHDPQHHTID SLEQGISSLM ERLHVMETQK KQERKVWSKS PRMQAGSEYR
ESWPPNSKLP HSQSSPAVSS TCTKVLYFTD RSLTPFMVNI PKRLGEVTLK DFKAAIDREG
NHRYHFKALD PEFGTVKEEV FHDDDAIPGW EGKIVAWVEE DHGEN
//
