ID I3MJV4_ICTTR Unreviewed; 629 AA.
AC I3MJV4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Glutamate metabotropic receptor 7 {ECO:0000313|Ensembl:ENSSTOP00000011493.3};
GN Name=GRM7 {ECO:0000313|Ensembl:ENSSTOP00000011493.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000011493.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000011493.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AGTP01073432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01073433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01073434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01073435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01073436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01073437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01073438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MJV4; -.
DR STRING; 43179.ENSSTOP00000011493; -.
DR Ensembl; ENSSTOT00000012826.3; ENSSTOP00000011493.3; ENSSTOG00000012823.3.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01030000234648; -.
DR HOGENOM; CLU_005389_0_0_1; -.
DR InParanoid; I3MJV4; -.
DR TreeFam; TF313240; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0010855; F:adenylate cyclase inhibitor activity; IEA:Ensembl.
DR GO; GO:0001642; F:group III metabotropic glutamate receptor activity; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
DR GO; GO:0070905; F:serine binding; IEA:Ensembl.
DR GO; GO:0061564; P:axon development; IEA:Ensembl.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0070085; P:glycosylation; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd15451; 7tmC_mGluR7; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001883; GPCR_3_mGluR7.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF98; METABOTROPIC GLUTAMATE RECEPTOR 7; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR01057; MTABOTROPC7R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 297..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 297..571
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 629 AA; 71024 MW; 1AFFE524799CFB2D CRC64;
QILAAAKRAD QVGHFLWVGS DSWGSKINPL HQHEDIAEGA ITIQPKRATV EGFDAYFTSR
TLENNRRNVW FAEYWEENFN CKLTISGSKK EDTDRKCTGQ ERIGKDSNYE QEGKVQFVID
AVYAMAHALH HMNKDLCADY RGVCPEMEQA GGKKLLKYIR NVNFNGSAGT PVMFNKNGDA
PGRYDIFQYQ TTNTTNPGYR LIGQWTDELQ LNIEDMQWGR GVREIPPSVC TLPCKPGQRK
KTQKGTPCCW TCEPCDGYQY QFDEMTCQHC PYDQRPNENR TGCQNIPIIK LEWHSPWAVI
PVFLAMLGII ATIFVMATFI RYNDTPIVRA SGRELSYVLL TGIFLCYIIT FLMIAKPDVA
VCSFRRVFLG LGMCISYAAL LTKTNRIYRI FEQGKKSVTA PRLISPTSQL AITSSLISVQ
LLGVFIWFGV DPPNIIVDYD EHKTMNPEQA RGVLKCDITD LQIICSLGYS ILLMVTCTVY
AIKTRGVPEN FNEAKPIGFT MYTTCIVWLA FIPIFFGTAQ SAEKLYIQTT TLTISMNLSA
SVALGMLYMP KVYIIIFHPE LNVQKRKRSF KAVVTAATMS SRLSHKPSDR PNGEAKTELC
ENVDPNNCIP PVRKSVQKSV TWYTIPPTV
//
