ID I3MJZ5_ICTTR Unreviewed; 464 AA.
AC I3MJZ5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Telomeric repeat binding factor 2 {ECO:0000313|Ensembl:ENSSTOP00000011548.3};
GN Name=TERF2 {ECO:0000313|Ensembl:ENSSTOP00000011548.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000011548.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000011548.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01009936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01009937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01009938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01009939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MJZ5; -.
DR Ensembl; ENSSTOT00000012883.3; ENSSTOP00000011548.3; ENSSTOG00000012882.3.
DR GeneTree; ENSGT00940000158316; -.
DR HOGENOM; CLU_034265_1_1_1; -.
DR TreeFam; TF333209; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0031848; P:protection from non-homologous end joining at telomere; IEA:InterPro.
DR CDD; cd11660; SANT_TRF; 1.
DR CDD; cd11654; TRF2_RBM; 1.
DR CDD; cd00280; TRFH; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.25.40.210; Telomere repeat-binding factor, dimerisation domain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR013867; Telomere_rpt-bd_fac_dimer_dom.
DR InterPro; IPR036507; Telomere_rpt-bd_fac_dimer_sf.
DR InterPro; IPR030657; TERF2.
DR InterPro; IPR031902; TERF2_RBM.
DR PANTHER; PTHR46833:SF1; TELOMERIC REPEAT-BINDING FACTOR 2; 1.
DR PANTHER; PTHR46833; TELOMERIC REPEAT-BINDING FACTOR 2 TERF2; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR Pfam; PF16772; TERF2_RBM; 1.
DR Pfam; PF08558; TRF; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF63600; Telomeric repeat binding factor (TRF) dimerisation domain; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 406..463
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT DOMAIN 406..459
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 464 AA; 51591 MW; 2AE850C35B720F0D CRC64;
MAAGAGTAGP ASGPGVVRDP SASQPRKRPS QEGGEGARRS DAMAGGGGSN DGSGRAAGRR
ASRSSGRARR GRHEPGLGGA AERGAGEARL EEAVNRWVLK FYFHEALRAF RGSRYGDFRQ
IRDIMQALLV RPLGKEHTVS RLLRVMQCLS RIEEGENLDC SFDMEAELTP LESAINVLEM
IKTEFTLTEA MIESSRKLVK EAAVIICIKN KEFEKASKIL KKHMSKDPTT QKLRNDLLNI
IREKNLAHPV IQNFSYETFQ QKMLRFLESH LDDTEPYLLT MAKKALKSES AASGTTKEDK
QPAPEPVEKP LREPARQLRN TPTTFGIMTL KAAFKALSGA QDSEAAFSKL DQKDLMPGQS
RGRDSAFGSL SKRKWNSSNG VEEKETWVEE DELFQVQAVP EEDSATSITK KQKWTVEESE
WVKAGVHKYG EGNWAAISKN YPFVNRTAVM IKDRWRTMKK LGMN
//
