ID   I3MKL1_ICTTR            Unreviewed;       766 AA.
AC   I3MKL1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=BMP/retinoic acid inducible neural specific 3 {ECO:0000313|Ensembl:ENSSTOP00000011855.2};
GN   Name=BRINP3 {ECO:0000313|Ensembl:ENSSTOP00000011855.2};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000011855.2, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000011855.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the BRINP family.
CC       {ECO:0000256|ARBA:ARBA00010360}.
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DR   EMBL; AGTP01014593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01014594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01014595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01014596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01014597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01014598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01014599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01014600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01014601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005319736.1; XM_005319679.1.
DR   STRING; 43179.ENSSTOP00000029964; -.
DR   Ensembl; ENSSTOT00000013227.3; ENSSTOP00000011855.2; ENSSTOG00000013227.3.
DR   Ensembl; ENSSTOT00000036727.1; ENSSTOP00000029964.1; ENSSTOG00000013227.3.
DR   GeneID; 101957966; -.
DR   CTD; 339479; -.
DR   eggNOG; ENOG502QQZS; Eukaryota.
DR   GeneTree; ENSGT00940000156099; -.
DR   HOGENOM; CLU_018347_0_0_1; -.
DR   OMA; CQCGPRF; -.
DR   OrthoDB; 3949486at2759; -.
DR   TreeFam; TF331600; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0071300; P:cellular response to retinoic acid; IEA:Ensembl.
DR   GO; GO:0021953; P:central nervous system neuron differentiation; IEA:Ensembl.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:InterPro.
DR   InterPro; IPR033237; BRINP.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR020864; MACPF.
DR   PANTHER; PTHR15564:SF2; BMP_RETINOIC ACID-INDUCIBLE NEURAL-SPECIFIC PROTEIN 3; 1.
DR   PANTHER; PTHR15564; MACPF DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF19052; BRINP; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00457; MACPF; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00022810};
KW   Growth arrest {ECO:0000256|ARBA:ARBA00022810};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           34..766
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014098444"
FT   DOMAIN          78..264
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|SMART:SM00457"
SQ   SEQUENCE   766 AA;  88502 MW;  B11D9AB6407A9DBB CRC64;
     MIWRSRAGAE LFSLMALWEW IALSLHCWVL AVAAVSDQHA TSPFDWLLSD KGPFHRSQEY
     TDFVDRSRQG FSTRYKIYRE FGRWKVNNLA VERRNFLGSP LPLAPEFFRN IRLLGRRPTL
     QQITENLIKK YGTHFLLSAT LGGEESLTIF VDKRKLSKRS EGSDTSTNSS SVTLETLHQL
     AASYFIDRDS TLRRLHHIQI ASTAIKVTET RTGPLGCSNY DNLDSVSSVL VQSPENKIQL
     QGLQVLLPDY LQERFVQAAL SYIACNSEGE FICKDNDCWC QCGPKFPECN CPSMDIQAME
     ENLLRITETW KAYNSDFEES DEFKFFMKRL PMNYFLNTST IMHLWTMDSN FQRRYEQLEN
     SMKQLFLKAQ KIVHKLFSLS KRCHKQPLIS LPRQRTSTYW LTRIQSFLYC NENGLLGSFS
     EETHSCTCPN DQVVCTSFLP CTVGDASACL TCAPDNRTRC GTCNTGYMLS QGLCKPEVAE
     STDHYIGFET DLQDLEMKYL LQKTDRRIEV HAIFISNDMR LNSWFDPSWR KRMLLTLKSN
     KYKSSLVHMI LGLSLQICLT KNSTLEPVLA VYINPFGGSH SESWFMPVNE NSFPDWERTK
     LDLPLQCYNW TLTLGNKWKT FFETVHIYLR SRIKSNGPNG NESIYYEPLE FIDPSRNLGY
     MKINNIQVFG YSMHFDPEAI RDLILQLDYP YTQGSQDSAL LQLLEIRDRV NKLSPPGQRR
     LDLFSCLLRH RLKLSTSEVV RIQSALQAFN AKLPNTMDYD TTKLCS
//