ID I3MLD2_ICTTR Unreviewed; 409 AA.
AC I3MLD2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Failed axon connections homolog, metaxin like GST domain containing {ECO:0000313|Ensembl:ENSSTOP00000012213.3};
GN Name=FAXC {ECO:0000313|Ensembl:ENSSTOP00000012213.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000012213.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000012213.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FAX family. {ECO:0000256|ARBA:ARBA00006475}.
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DR EMBL; AGTP01086438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005335933.1; XM_005335876.1.
DR AlphaFoldDB; I3MLD2; -.
DR STRING; 43179.ENSSTOP00000012213; -.
DR Ensembl; ENSSTOT00000013631.3; ENSSTOP00000012213.3; ENSSTOG00000013626.3.
DR GeneID; 101958516; -.
DR CTD; 84553; -.
DR eggNOG; KOG4244; Eukaryota.
DR GeneTree; ENSGT00950000182919; -.
DR HOGENOM; CLU_044137_2_0_1; -.
DR InParanoid; I3MLD2; -.
DR OrthoDB; 3684737at2759; -.
DR TreeFam; TF314915; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR CDD; cd03193; GST_C_Metaxin; 1.
DR CDD; cd03080; GST_N_Metaxin_like; 1.
DR InterPro; IPR026928; FAX/IsoI-like.
DR InterPro; IPR045796; FAXC_N.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12289:SF76; FAILED AXON CONNECTIONS HOMOLOG; 1.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR Pfam; PF19333; FAXC_N; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF17172; GST_N_4; 1.
DR SFLD; SFLDG01180; SUF1; 1.
DR SFLD; SFLDG01200; SUF1.1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 1..106
FT /note="Failed axon connections homolog N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19333"
FT DOMAIN 117..211
FT /note="Thioredoxin-like fold"
FT /evidence="ECO:0000259|Pfam:PF17172"
FT DOMAIN 264..326
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
FT REGION 372..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 46815 MW; 4B0BC251E83060E8 CRC64;
MHWGVGFASS RPCVVDLSWN QSVSFFGWWA GSEEPFSFYG DIIAFPLQDY GGIMAGLGSD
PWWKKTLYLT GGALLAAAAY LLHELLVIRK QQEIDSKDAI ILHQFARPNN GVPSLSPFCL
KMETYLRMAD LPYQNYFGGK LSAQGKMPWI EYNHEKVSGT EFIIDFLEEK LGVNLNKNLG
PHERAVSRAV TKMVEEHFYW TLAYCQWVDN LNETRKMLSL SGGGPFSNLL RWVVCHITKG
IVKREMHGHG IGRFSEEEIY MLMEKDMRSL AGLLGDKKYI MGPKLSTLDA TVFGHLAQAM
WTLPGTRPER LIKGELINLA MYCERIRRKF WPEWHHDDDN TIYESEESSE GSKTHTPLLD
FSFYSRTETF EDEGAENSFS RTPDTDFTGH SLFDSDVDMD DYTDHEQCK
//
