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Database: UniProt
Entry: I3MNK9_ICTTR
LinkDB: I3MNK9_ICTTR
Original site: I3MNK9_ICTTR 
ID   I3MNK9_ICTTR            Unreviewed;      2193 AA.
AC   I3MNK9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   20-DEC-2017, entry version 40.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1C {ECO:0000313|Ensembl:ENSSTOP00000013255};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000013255, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000013255}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000013255}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000013255}.
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DR   EMBL; AGTP01074468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01074469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01074470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01074471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01074472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01074473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01074474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01074475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01074476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000013255; -.
DR   Ensembl; ENSSTOT00000014797; ENSSTOP00000013255; ENSSTOG00000014780.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; I3MNK9; -.
DR   OMA; PTTKINM; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:1990454; C:L-type voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0051393; F:alpha-actinin binding; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0086056; F:voltage-gated calcium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0061577; P:calcium ion transmembrane transport via high voltage-gated calcium channel; IEA:Ensembl.
DR   GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR   GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0002520; P:immune system development; IEA:Ensembl.
DR   GO; GO:0098912; P:membrane depolarization during atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005451; VDCC_L_a1csu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 2.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01635; LVDCCALPHA1C.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    156    173       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    193    213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    225    243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    296    318       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    377    398       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    410    432       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    578    595       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    615    638       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    707    726       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    779    806       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    949    972       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    984   1003       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1024   1050       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1070   1099       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1195   1222       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1273   1290       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1302   1324       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1412   1435       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1505   1529       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1663   1697       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      809    835       {ECO:0000256|SAM:Coils}.
FT   COILED     1624   1644       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2193 AA;  246107 MW;  4ED0CDDD2C37E646 CRC64;
     MLRAFVQPST PAYQPLSSHL SAETEVKFKG TLVHEAQLNC FYISPGGSNY GSPRSANMNA
     NAAAGLAPEH IPTPGAALSW QAAIDAARQA KLMGSAGNAT ISTVSSTQRK RQQYGKPKKQ
     SGTTATRPPR ALLCLTLKNP IRRACISIVE WKPFEIIILL TIFANCVALA IYIPFPEDDS
     NATNSNLERV EYLFLIIFTV EAFLKVIAYG LLFHPNAYLR NGWNLLDFII VVVGLFSAIL
     EQATKADGAN ALGGKGAGFD VKALRAFRVL RPLRLVSGVP SLQVVLNSII KAMVPLLHIA
     LLVLFVIIIY AIIGLELFMG KMHKTCYNQE GIADVPAEED PSPCALETGH GRQCQNGTVC
     KPGWDGPKHG ITNFDNFAFA MLTVFQCITM EGWTDVLYWM QDAMGYELPW VYFVSLVIFG
     SFFVLNLVLG VLSGEFSKER EKAKARGDFQ KLREKQQLEE DLKGYLDWIT QAEDIDPENE
     DEGMDEEKPR NRGTPAGLLD QKKGKFAWFS HSTETHVSMP TSETESVNTE NVAGGDIEGE
     NCGARLAHRI SKSKFSRYWR RWNRFCRRKC RAAVKSNVFY WLVIFLVFLN TLTIASEHYN
     QPHWLTEVQD TANKALLALF TAEMLLKMYS LGLQAYFVSL FNRFDCFIVC GGILETILVE
     TKIMSPLGIS VLRCVRLLRI FKITRYWNSL SNLVASLLNS VRSIASLLLL LFLFIIIFSL
     LGMQLFGGKF NFDEMQTRRS TFDNFPQSLL TVFQILTGED WNSVMYDGIM AYGGPSFPGM
     LVCIYFIILF ICGNYILLNV FLAIAVDNLA DAESLTSAQK EEEEEKERKK LARTASPEKK
     QEVVEKPAVE ETKEEKIELK SITADGESPP TTKINMDDLQ PNENEDKSSY PNPEAAGEED
     EEEPEMPVGP RPRPLSELHL KEKAVPMPEA SAFFIFSPNN RFRLQCHRIV NHTIFTNLIL
     FFILLSSISL AAEDPVQHTS FRNHILFYFD IVFTTIFTIE IALKMTAYGA FLHKGSFCRN
     YFNILDLLVV SVSLISFGIQ SSAINVVKIL RVLRVLRPLR AINRAKGLKH VVQCVFVAIR
     TIGNIVIVTT LLQFMFACIG VQLFKGKLYT CSDSSKQTEA ECKGNYITYK DGEVDHPIIQ
     PRSWENSKFD FDNVLAAMMA LFTVSTFEGW PELLYRSIDS HTEDKGPIYN YRVEISIFFI
     IYIIIIAFFM MNIFVGFVIV TFQEQGEQEY KNCELDKNQR QCVEYALKAR PLRRYIPKNQ
     HQYKVWYVVN STYFEYLMFV LILLNTICLA MQHYGQSCLF KIAMNILNML FTGLFTVEMI
     LKLIAFKPKG YFSDPWNVFD FLIVIGSIID VILSETNPAE HTQCSPSMNA EENSRISITF
     FRLFRVMRLV KLLSRGEGIR TLLWTFIKSF QALPYVALLI VMLFFIYAVI GMQVFGKIAL
     NDTTEINRNN NFQTFPQAVL LLFRCATGEA WQDIMLACMP GKKCAPESEP SNSTEGETPC
     GSSFAVFYFI SFYMLCAFLI INLFVAVIMD NFDYLTRDWS ILGPHHLDEF KRIWAEYDPE
     AKGRIKHLDV VTLLRRIQPP LGFGKLCPHR VACKRLVSMN MPLNSDGTVM FNATLFALVR
     TALRIKTEGN LEQANEELRA IIKKIWKRTS MKLLDQVVPP AGDDEVTVGK FYATFLIQEY
     FRKFKKRKEQ GLVGKPSQRN ALSLQAGLRT LHDIGPEIRR AISGDLTAEE ELDKAMKEAV
     SAASEDDIFR RAGGLLVNHV NYYQSDSRGA FPQTFTTQRP LHINKAGNNQ GDTESPSHEK
     LVDSTFTPSS YSSTGSNANI NNANNTALGR FPRPSGYPST VSTVEGHGPP LSPAIRVQEA
     AWKLNSRRCS SRDSQLAMVC QEDGSREETY DVKMSEEAEY CSEPSLLSTE MLSYQDDENR
     QLTPPEEDKR DIRQSPKRGF LRSASLGRRA SFHLECLKRQ KNQGGDISQK TVLPLHLVHH
     QALAVAGLSP LLQRSHSPTT FPRPCATPPA TPGTRAWPPQ PIPTLRLEGA ESIEKLNSSF
     PSIHCSSWSE ETASCSGGSN TIRRARPVSL TVPTQAAAPG RQFHGSASSL VEAVLISEGL
     GQFAQDPKFI EVTTQELADA CDMTIEEMEN AADSILSGGA QQSPNGTLLP FVNCRDPGQD
     RAGGEEDGSC ARALGRGRSE EELQDSRVYV SSL
//
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