ID   I3MNU3_ICTTR            Unreviewed;       284 AA.
AC   I3MNU3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Homeobox B13 {ECO:0000313|Ensembl:ENSSTOP00000013380.2};
GN   Name=HOXB13 {ECO:0000313|Ensembl:ENSSTOP00000013380.2};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000013380.2, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000013380.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC       {ECO:0000256|ARBA:ARBA00006317}.
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DR   EMBL; AGTP01023188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005321770.1; XM_005321713.1.
DR   AlphaFoldDB; I3MNU3; -.
DR   STRING; 43179.ENSSTOP00000013380; -.
DR   Ensembl; ENSSTOT00000014935.3; ENSSTOP00000013380.2; ENSSTOG00000014942.3.
DR   GeneID; 101972553; -.
DR   CTD; 10481; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000159029; -.
DR   HOGENOM; CLU_059940_1_0_1; -.
DR   InParanoid; I3MNU3; -.
DR   OMA; HPPDGCA; -.
DR   OrthoDB; 728401at2759; -.
DR   TreeFam; TF330813; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0008327; F:methyl-CpG binding; IEA:Ensembl.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0060743; P:epithelial cell maturation involved in prostate gland development; IEA:Ensembl.
DR   GO; GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; IEA:Ensembl.
DR   GO; GO:0040008; P:regulation of growth; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR022067; HoxA13_N.
DR   PANTHER; PTHR45804:SF6; HOMEOBOX PROTEIN HOX-B13; 1.
DR   PANTHER; PTHR45804; SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF12284; HoxA13_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          214..274
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        216..275
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   284 AA;  30754 MW;  1CFF9C5270D10063 CRC64;
     MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLPSHPAAP TLMPAVNYGP LDLPGSAEPP
     KQCHPCPGVP QRASPAPVPY GYFGGGYYSC RVSRSSLKPC AQAATLAAYP TETPAAGEEY
     PSRPTEFAFY PGYPGPYQPM ASYLDVSVVQ TLGAPGEPRH DSLLPVDSYQ PWALASGWNS
     QMCCQGEQNP PGPFWKAAFA DSSAQHPSEG CAFRRGRKKR IPYSKGQLRE LEREYAANKF
     ITKDKRRKIS AATSLSERQI TIWFQNRRVK EKKVLAKVKT SATP
//