ID I3MPZ2_ICTTR Unreviewed; 1208 AA.
AC I3MPZ2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Fibronectin type III domain containing 3B {ECO:0000313|Ensembl:ENSSTOP00000013940.3};
GN Name=FNDC3B {ECO:0000313|Ensembl:ENSSTOP00000013940.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000013940.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000013940.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FNDC3 family.
CC {ECO:0000256|ARBA:ARBA00038207}.
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DR EMBL; AGTP01070225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01070226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01070227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005332523.1; XM_005332466.2.
DR RefSeq; XP_005332524.1; XM_005332467.2.
DR AlphaFoldDB; I3MPZ2; -.
DR STRING; 43179.ENSSTOP00000013940; -.
DR Ensembl; ENSSTOT00000015576.3; ENSSTOP00000013940.3; ENSSTOG00000015567.3.
DR GeneID; 101958588; -.
DR CTD; 64778; -.
DR eggNOG; ENOG502QRT8; Eukaryota.
DR GeneTree; ENSGT00940000157005; -.
DR HOGENOM; CLU_004152_1_0_1; -.
DR InParanoid; I3MPZ2; -.
DR OrthoDB; 316463at2759; -.
DR TreeFam; TF316401; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 9.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF11; FIBRONECTIN TYPE III DOMAIN-CONTAINING 3BA-RELATED; 1.
DR Pfam; PF00041; fn3; 9.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR PROSITE; PS50853; FN3; 9.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1183..1206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 282..381
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 385..477
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 481..574
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 578..673
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 677..771
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 773..863
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 875..961
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 962..1056
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1060..1157
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 186..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1208 AA; 132936 MW; 5845A66A5BFE95BE CRC64;
MYVTMMMTDQ IPLELPPLLN GEVTMMPPHL VNGEAAQQVI LVQVNPGETF TIRAEDGTLQ
CIQGPAEVPM MSPNGSIPPI HVPPGYISQV IEDSTGVRRV VVTPQSPECY PPSYPSAMSP
THHLPPYLTH HPHFIHNSHT AYYPPVTGPG DMPPQFFPQH HLPPTIYGEQ EIIPLYGMSS
YITREDQYSK PPHKKLKDRQ IDRQNRLNSP PSSIYKSNCT TVYNGYGKGH SGGGGGGGGG
GSGGGPGIKK TERRARSSPK SNDSDLQEYE LEVKRVQDIL SGIEKPQVSN IQARAVVLSW
APPVGLSCGP HSGLSFPYSY EVALSDKGRD GKYKIIYSGE ELECNLKDLR PATDYHVRVY
AMYNSVKGSC SEPVSFTTHS CAPECPFPPK LAHRSKSSLT LQWKAPIDNG SKITNYLLEW
DEGKRNSGFR QCFFGSQKHC KLTKLCPAMG YTFRLAARND IGTSGYSQEV VCYTLGNIPQ
MPSAPRLVRA GVTWVTLQWN KPEGCSPEEV ITYTLEIQED ENDNLFHPKY TGEDLTCTVK
NLKRSTQYKF RLTASNMEGK SCPSEVLVCT TSPDRPGPPT RPLIKGPVTS HGFGVKWDPP
KDNGGSEILK YLLEITDGNS EANQWEVAYS GSATEYTFTQ LKPGTLYKLR ACCISTGGHS
QCSESLPVRT LSIAPGQCRP PRVLGRPKHK EVHLEWDVPT SESGCEVSEY SVEMTEPEDV
ASEVYHGPEL ECTVGNLLPG TVYRFRVRAL NDGGYGPYSD VSEITTATGP PGQCKAPCVS
FTPEGCVLVS WESPESSGAD ISEYRLEWGE DEESLELVYH GTDTCFEIKD LLPAAQYCCR
LQAFNQAGAG PYSELVLCQT PASAPDPVST LCVLEEEPLS ASPDSPSVCL VLTWEEPCNN
GSEILAYNID LGDASITVGN TTTHVVKGLL PETSYRIRIQ AINEIGAGPF SQFIKAKTRP
LPPSPPRLEC AAAGPQSLKL KWGDSNSKTH TADDIVYTLQ LEDRNKRFIS IYRGPSHTYK
VQRLTEFTCY SFRIQAASEA GEGPFSEIYT FSTTKSVPPT IKAPRVTQLE GNSCEILWET
VPPMKGDPVN YILQVLVGRE SEYKQVYKGE EATFQISGLQ SNTDYRFRVC ACRRCLDTSQ
ELSGAFSPSV AFVLQRSEVM LTGDMGSLDD PKMKSMMPTD EQFAALIVLG FATLSILFAF
ILQYFLMK
//
