ID I3MRE2_ICTTR Unreviewed; 602 AA.
AC I3MRE2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=EBF family member 4 {ECO:0000313|Ensembl:ENSSTOP00000014644.3};
GN Name=EBF4 {ECO:0000313|Ensembl:ENSSTOP00000014644.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000014644.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000014644.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004489}.
CC -!- SIMILARITY: Belongs to the COE family. {ECO:0000256|ARBA:ARBA00010340,
CC ECO:0000256|RuleBase:RU004489}.
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DR EMBL; AGTP01017827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01017828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01017829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005320602.1; XM_005320545.2.
DR AlphaFoldDB; I3MRE2; -.
DR Ensembl; ENSSTOT00000016355.3; ENSSTOP00000014644.3; ENSSTOG00000016352.3.
DR GeneID; 101970996; -.
DR CTD; 57593; -.
DR eggNOG; KOG3836; Eukaryota.
DR GeneTree; ENSGT00950000182859; -.
DR HOGENOM; CLU_016320_3_0_1; -.
DR OrthoDB; 3641706at2759; -.
DR TreeFam; TF313391; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd11606; COE_DBD; 1.
DR CDD; cd01175; IPT_COE; 1.
DR Gene3D; 1.10.287.4280; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.3180; Transcription factor COE1, DNA-binding domain; 1.
DR InterPro; IPR032200; COE_DBD.
DR InterPro; IPR038173; COE_DBD_sf.
DR InterPro; IPR032201; COE_HLH.
DR InterPro; IPR038006; COE_IPT.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR003523; Transcription_factor_COE.
DR InterPro; IPR018350; Transcription_factor_COE_CS.
DR PANTHER; PTHR10747; TRANSCRIPTION FACTOR COE FAMILY MEMBER; 1.
DR PANTHER; PTHR10747:SF36; TRANSCRIPTION FACTOR COE4; 1.
DR Pfam; PF16422; COE1_DBD; 1.
DR Pfam; PF16423; COE1_HLH; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR PROSITE; PS01345; COE; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Developmental protein {ECO:0000256|RuleBase:RU004489};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004489};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004489};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004489};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004489};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004489};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004489};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004489}.
FT DOMAIN 255..339
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT REGION 448..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 64555 MW; D83B774590197254 CRC64;
MFPAQDALPR GGLNLKEEPL LPAGLGSVRS WMQGAGILDS STAAQSGVGL ARAHFEKQPP
SNLRKSNFFH FVLAMYDRQG QPVEVERTAF IDFVEKDREP GAEKTNNGIH YRLRLVYNNG
LRTEQDLYVR LIDSMSKQAI IYEGQDKNPE MCRVLLTHEI MCSRCCDRKS CGNRNETPSD
PVIIDRFFLK FFLKCNQNCL KNAGNPRDMR RFQVVVSTTV SVDGHVLAVS DNMFVHNNSK
HGRRARRLDP SEAATPCIKA ISPGEGWTTG GATVIVIGDN FFDGLQVVFG NVLVWSELIT
PHAIRVQTPP RHIPGVVEVT LSYKSKQFCK GAPGRFVYTA LNEPTIDYGF QRLQKVIPRH
PGDPERLPKE VLLKRAADLA EALYGVPSSN QELLLKRAAD VAEALYSAPR APAPLGPLAP
SHPHPAVVGI NAFSSPLAIA VGDATPGPEP GYARSCSSAS PRGFAPSPGS QQSSYGSGLG
AGLSGYGAPG VAGLGVPGSP SFLNGSTATS PFAIMPSSPP LAAASSMSLP AAAPTTSVFS
FSPVNMISAV KQRSAFAPVL RPPSSPPQAC PRVHGEGLPD QPFEDSDKFH SPARGLQGLA
YS
//
