ID I3MVR9_ICTTR Unreviewed; 1238 AA.
AC I3MVR9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Neurofascin {ECO:0000313|Ensembl:ENSSTOP00000016214.2};
GN Name=NFASC {ECO:0000313|Ensembl:ENSSTOP00000016214.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000016214.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000016214.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR EMBL; AGTP01058289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01058290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01058291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01058292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MVR9; -.
DR Ensembl; ENSSTOT00000029367.2; ENSSTOP00000016214.2; ENSSTOG00000002615.3.
DR eggNOG; KOG3513; Eukaryota.
DR GeneTree; ENSGT00940000157024; -.
DR HOGENOM; CLU_047917_0_0_1; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05731; Ig3_L1-CAM_like; 1.
DR CDD; cd05845; IgI_2_L1-CAM_like; 1.
DR CDD; cd05875; IgI_hNeurofascin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR InterPro; IPR026965; NFASC_Ig-like.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1238
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011977284"
FT TRANSMEM 1108..1129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..141
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 147..234
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 248..336
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 341..428
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 433..521
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 525..607
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 634..729
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 731..827
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 831..930
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1005..1097
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 714..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1209..1223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1238 AA; 137749 MW; 97D986E0158C8500 CRC64;
MARQQPPPWV HAAFLLFFLS LGGAIEIPMD PSIQNERKSL LTQPPTITKQ SVKDHIVDPR
DNILIECEAK GNPAPSFHWT RNSRFFNIAK DPRVSMRRRS GTLVIDFRSG GRPEEYEGEY
QCFARNKFGT ALSNRIRLQV SKSPLWPKEN LDPVVVQEGA PLTLQCNPPP GLPSPVIFWM
SSSMEPITQD KRVSQGHNGD LYFSNVMLQD MQTDYSCNAR FHFTHTIQQK NPFTLKVLTT
RGVAERTPSF MYPQGTSSSQ MVLRGMDLLL ECIASGVPTP DIAWYKKGGD LPSDKAKFEN
FNKALRITNV SEEDSGEYFC LASNKMGSIR HTISVRVKAA PYWLDEPKNL ILAPGEDGRL
VCRANGNPKP TVQWMVNGEP LQSAPPNPNR EVAGDTIIFR DTQISSRAVY QCNTSNEHGY
LLANAFVSVL DVPPRMLSPR NQFIRVILYN RTRLDCPFFG SPIPTLRWFK NGQGSNLDGG
NYHVYENGSL EIKMIRKEDQ GIYTCVATNI LGKAENQVRL EVKDPTRIYR MPEDQVAKRG
TTVQLECRVK HDPSLKLTVS WLKDDEPLYI GNRMKKEDDS LTIFGVAERD QGSYTCVAST
ELDQDLAKAY LTVLADQATP TNRLAALPKG RPDRPRDLEL TDLAERSVRL TWIPGDDNNS
PITDYVVQFE EDQFQPGVWH DHSKFPGSVN SAVLQLSPYV NYQFRVIAVN EVGSSHPSLP
SERYRTSGAP PESNPSDVKG EGTRKNNMEI TWTPMNATSA FGPNLRYIVK WRRRETRETW
NNVTVWGSRY VVGQTPVYVP YEIRVQAEND FGKAPEPDTV IGYSGEDLPS APRRFRVRQP
NLETINLEWD HPEHPNGILI GYTLKYVAFN GTKVGKQMVE NFSPNQTKFS MQRADPVSRY
RFTLSARTQV GSGEAVTEES PAPPNEAPPT LPPTTVGATG AVSSTDATAL AAATEATTVP
IIPTVAPTTV ATTTTTVATT TTTTAATTTE SPPTTTTGTK IQESAPDEQS IWNVTVLPNS
KWANITWKHN FGPGTDFVVE YIDSNHTKKT VPVKAQAQPI QLTDLYPGMT YTLRVYSRDN
EGISSTVITF MTSTAYTNNQ ADIATQGWFI GLMCAIALLV LILLIVCFIK RSRGGKYPVR
EKKDVPLGPE DPKEEDGSFD YSDEDNKPLQ GSQTSLDGTI KQQESDDSLV DYGEGGEGQF
NEDGSFIGQY TVKKDKEETE GNESSEATSP VNAIYSLA
//
