ID I3MY76_ICTTR Unreviewed; 184 AA.
AC I3MY76;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Retina and anterior neural fold homeobox protein 2 {ECO:0000256|ARBA:ARBA00019389};
DE AltName: Full=Retina and anterior neural fold homeobox-like protein 1 {ECO:0000256|ARBA:ARBA00033377};
GN Name=RAX2 {ECO:0000313|Ensembl:ENSSTOP00000017072.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000017072.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000017072.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in modulating the expression of photoreceptor
CC specific genes. Binds to the Ret-1 and Bat-1 element within the
CC rhodopsin promoter. {ECO:0000256|ARBA:ARBA00025251}.
CC -!- SUBUNIT: Interacts with CRX. {ECO:0000256|ARBA:ARBA00011785}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR EMBL; AGTP01068836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005332088.1; XM_005332031.1.
DR AlphaFoldDB; I3MY76; -.
DR STRING; 43179.ENSSTOP00000017072; -.
DR Ensembl; ENSSTOT00000029709.2; ENSSTOP00000017072.2; ENSSTOG00000024315.2.
DR GeneID; 101969699; -.
DR CTD; 84839; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000163572; -.
DR HOGENOM; CLU_047013_4_0_1; -.
DR InParanoid; I3MY76; -.
DR OMA; HIASLRM; -.
DR OrthoDB; 3042435at2759; -.
DR TreeFam; TF315976; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR043562; RAX/RAX2.
DR PANTHER; PTHR46271; HOMEOBOX PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR46271:SF2; RETINA AND ANTERIOR NEURAL FOLD HOMEOBOX PROTEIN 2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 25..85
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 27..86
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 184 AA; 19994 MW; E4B869C7F595B986 CRC64;
MFLSLGEGPG PEGGGLGPGE EAPKKKHRRS RTTFTTYQLH QLERAFEASH YPDVYSREEL
AAKVHLPEVR VQVWFQNRRA KWRRQERLES GSGAVAAPRL PEAPTLPLAR PPALQLPLEP
WLGPGPQAGP GLPHVLGSAP GLQASLGPHA FPPTLADGFA LEEASLRLLA KEHAQALDRA
WPPA
//
