GenomeNet

Database: UniProt
Entry: I3N0U5_ICTTR
LinkDB: I3N0U5_ICTTR
Original site: I3N0U5_ICTTR 
ID   I3N0U5_ICTTR            Unreviewed;      1804 AA.
AC   I3N0U5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   22-NOV-2017, entry version 39.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1I {ECO:0000313|Ensembl:ENSSTOP00000017991};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000017991, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000017991}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000017991}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000017991}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTP01024117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000017991; -.
DR   Ensembl; ENSSTOT00000023492; ENSSTOP00000017991; ENSSTOG00000025056.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; I3N0U5; -.
DR   OMA; SPSVNCT; -.
DR   OrthoDB; EOG091G02L1; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0030431; P:sleep; IEA:Ensembl.
DR   InterPro; IPR030162; CACNA1I.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF209; PTHR10037:SF209; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
SQ   SEQUENCE   1804 AA;  199779 MW;  81650AA0B9CD2D91 CRC64;
     MAESTPPASS SAAAPAPELG ITAQPGPQSP PPSPPGLEEP LDGADPEVPH PDLAPVAFFC
     LRQTTSPRNW CIKMVCNPYP LLRVILDRCP GAAVVPPSSP LGPELNSAWV CGSLMVEYSL
     DLQNINLSAI RTVRVLRPLK AINRVPSMRI LVNLLLDTLP MLGNVLLLCF FVFFIFGIIG
     VQLWAGLLRN RCFLEENFTL SRCPQAGCGR RGQSREACSH EEQEHGAGNS EGCPTRAACA
     RPGAHQALPS RPRCRLQVIT LEGWVEIMYY VMDAHSFYNF IYFILLIIVG SFFMINLCLV
     VIATQFSETK QREHRLMLEQ RQRYLSSSTV ASYAEPGDCY EEIFQYVCHI LRKAKRRTLG
     LYQALQSRRQ ALGPGAPAPA RPGPHAWGGH RHCLLCPRHS ALDPTPHTLV QPISAMLASD
     PTSCPHCQHG AGRRSSGPGS TDSGQEGSGS GGSSGSEAEA DGDGPRSSED GGSSGLGKED
     EEGQVGAVRL CGDVWRETRA KLRGIVDSKY FNRGIMMAIL VNTVSMGIEH HEQPEELTNI
     LEICNVVFTS MFALEMILKL AAFGLFDYLR NPYNIFDSII VIISIWEIVG QADGGLSVLR
     TFRLLRVLKL VRFMPALRRQ LVVLMKTMDN VATFCMLLML FIFIFSILGM HIFGCKFSLR
     TDTGDTVPDR KNFDSLLWAI VTVFQILTQE DWNVVLYNGM ASTSPWASLY FVALMTFGNY
     VLFNLLVAIL VEGFQAEGDA NRSYSDEDQS SSNMEEYDKF QEALDSSGDP KLCPIPLTPN
     GHLDPSLPLG GHLGPTGAVG PASRLSLQPD PMLVALDSRK SSVMSLGRMS YDQRSLSSTR
     SSYYGPWGRS GAWASRRSSW NSLKHKPPSA EHESLLSAER SGARACEGAR EEGPPRAAPL
     HAPHAHHVHH GPHLAHRHRH HRRTLSLDTR DSVDLTELLP AMGLHPRAAW RAAGMAPGHE
     DCNGRMPNIA KDVFTKMDDG RDRGEDEEEI DYPDWCEVRE DWSVYLFSPE NRFRVLCQTI
     IAHKLFDYVV LAFIFLNCIT IALERPQIEA GSTERIFLTV SNYIFTAIFV GEMTLKVALG
     FTFTPSSGTP APPADCHWPV TSAGGAKILG VLRVLRLLRT LRPLRVISRA PGLKLVVETL
     ISSLKPIGNI VLICCAFFII FGILGVQLFK GKFYHCLGVD TRNITNRSDC VAANYRWVHH
     KYNFDNLGQA LMSLFVLASK DGWVNIMYNG LDAVAVDQQP VTNHNPWMLL YFISFLLIVS
     FFVLNMFVGV VVENFHKCRQ HQEAEEARRR EEKRLRRLEK KRRSEWAARG PGCVLSPSQA
     PVTPSLETAL KYCNYMFTTV FVLEAVLKLV AFGLRRFFKD RWNQLDLAIV LLSVMGITLE
     EIEINAALPI NPTIIRIMRV LRIARVLKLL KMATGMRALL DTVVQALPQV GNLGLLFMLL
     FFIYAALGVE LFGKLVCNEE NPCEGMSRHA TFENFGMAFL TLFQVSTGDN WNGIMKDTLR
     DCTQEEHSCL SSLQFVSPLY FVSFVLTAQF VLINVVVAVL MKHLDDSNKE AQEDAEMDAE
     IELEMAHGLG PSPRPPPSSP GALGRGPGGA GGGGDAEGRL CRRCYSPAQE NLWLDSVSLI
     IKDSLEGELT IIDNLSGSIF HHYASPAGCE KCHHDQQEVQ LAETEAFSLN SDKSSSILLG
     DDLSLEDPAA CPPGPKDSKG PLHPPTRVGD LGECFFPLSN MAMSTGAENF LCEMEAIPFN
     PVRSWLKHES SQGEGWGPQP PHPTPPSLIL GICFRPRWLS FSLVFLPRLL YLFQKEPDGY
     LTMR
//
DBGET integrated database retrieval system