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Database: UniProt
Entry: I3N0U5_ICTTR
LinkDB: I3N0U5_ICTTR
Original site: I3N0U5_ICTTR 
ID   I3N0U5_ICTTR            Unreviewed;      1770 AA.
AC   I3N0U5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-SEP-2017, entry version 37.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1I {ECO:0000313|Ensembl:ENSSTOP00000017991};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000017991, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000017991}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000017991}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000017991}.
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DR   EMBL; AGTP01024117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01024126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000017991; -.
DR   Ensembl; ENSSTOT00000023492; ENSSTOP00000017991; ENSSTOG00000025056.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; I3N0U5; -.
DR   OMA; SPSVNCT; -.
DR   OrthoDB; EOG091G02L1; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0030431; P:sleep; IEA:Ensembl.
DR   InterPro; IPR030162; CACNA1I.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF258; PTHR10037:SF258; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     47     71       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    210    235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    472    498       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    505    524       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    563    585       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    641    663       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    971    989       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1009   1029       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1106   1125       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1205   1228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1317   1340       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1418   1437       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1504   1526       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        9    246       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      441    668       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      969   1238       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1309   1536       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1237   1264       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1770 AA;  196196 MW;  C97EBFF5018E8615 CRC64;
     MVEYSLDLQN INLSAIRTVR VLRPLKAINR VPSMRILVNL LLDTLPMLGN VLLLCFFVFF
     IFGIIGVQLW AGLLRNRCFL EENFTLQGRT AQRQRHQGGA PEPAPRLQPV SQKNRLCRSY
     SLGPLGRQGR AASGHGDMGD LGSGAHLTNA QKENRGWSKI SAVHVSTRGS PLQNLWSHDS
     PGSSTAWLFD VITLEGWVEI MYYVMDAHSF YNFIYFILLI IVGSFFMINL CLVVIATQFS
     ETKQREHRLM LEQRQRYLSS STVASYAEPG DCYEEIFQYV CHILRKAKRR TLGLYQALQS
     RRQALGPGAP APARPGPHAK DPRHCKLCPR HSALDPTPHT LVQPISAMLA SDPTSCPHCQ
     HGAGRRSSGP GSTDSGQEGS GSGGSSGSEA EADGDGPRSS EDGGSSGLGK EDEEGQVGAV
     RLCGDVWRET RAKLRGIVDS KYFNRGIMMA ILVNTVSMGI EHHEQASELT NILEICNVVF
     TSMFALEMIL KLAAFGLFDY LRNPYNIFDS IIVIISIWEI VGQADGGLSV LRTFRLLRVL
     KLVRFMPALR RQLVVLMKTM DNVATFCMLL MLFIFIFSIL GMHIFGCKFS LRTDTGDTVP
     DRKNFDSLLW AIVTVFQILT QEDWNVVLYN GMASTSPWAS LYFVALMTFG NYVLFNLLVA
     ILVEGFQAEG DANRSYSDED QSSSNMEEYD KFQEALDSSG DPKLCPIPLT PNGHLDPSLP
     LGGHLGPTGA VGPASRLSLQ PDPMLVALDS RKSSVMSLGR MSYDQRSLSS TRSSYYGPWG
     RSGAWASRRS SWNSLKHKPP SAEHESLLSA ERSGARACEG AREEGPPRAA PLHAPHAHHV
     HHGPHLAHRH RHHRRTLSLD TRDSVDLTEL LPAMGLHPRA AWRAAGMAPG HEDCNGRMPN
     IAKDVFTKMD DGRDRGEDEE EIDYVSGAEV GSRGRARAPD WCEVREDWSV YLFSPENRFR
     VLCQTIIAHK LFDYVVLAFI FLNCITIALE RPQIEAGSTE RIFLTVSNYI FTAIFVGEMT
     LKVALGFTFT PSSGTPAPPA DCHWPVRSAW SCPLPTPSAG GAKILGVLRV LRLLRTLRPL
     RVISRAPGLK LVVETLISSL KPIGNIVLIC CAFFIIFGIL GVQLFKGKFY HCLGVDTRNI
     TNRSDCVAAN YRWVHHKYNF DNLGQALMSL FVLASKDGWV NIMYNGLDAV AVDQQPVTNH
     NPWMLLYFIS FLLIVSFFVL NMFVGVVVEN FHKCRQHQEA EEARRREEKR LRRLEKKRRS
     EARVPAEAIT GPSVLCPLPL GAHVYMHIFV LNMNGLNSLL KGRDFLQKVS LETALKYCNY
     MFTTVFVLEA VLKLVAFGLR RFFKDRWNQL DLAIVLLSVM GITLEEIEIN AALPINPTII
     RIMRVLRIAR VLKLLKMATG MRALLDTVVQ ALPQVGNLGL LFMLLFFIYA ALGVELFGKL
     VCNEENPCEG MSRHATFENF GMAFLTLFQV STGDNWNGIM KDTLRDCTQE EHSCLSSLQF
     VSPLYFVSFV LTAQFVLINV VVAVLMKHLD DSNKEAQEDA EMDAEIELEM AHGLGPSPRP
     PPSSPGALGR GPGGAGGGGD AEGRLCRRCY SPAQENLWLD SVSLIIKDSL EGELTIIDNL
     SGSIFHHYAS PAGCEKCHHD QQEVQLAETE AFSLNSDKSS SILLGDDLSL EDPAACPPGP
     KDSKGELDPL EPTRVGDLGE CFFPLSNMAM STGAENFLCE MEAIPFNPVR SWLKHESSQA
     PPTPYSPDAS SPLLTMPAEF FHPAVSASQK
//
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