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Database: UniProt
Entry: I3N2T4_ICTTR
LinkDB: I3N2T4_ICTTR
Original site: I3N2T4_ICTTR 
ID   I3N2T4_ICTTR            Unreviewed;       655 AA.
AC   I3N2T4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   31-JAN-2018, entry version 36.
DE   SubName: Full=Potassium voltage-gated channel subfamily D member 3 {ECO:0000313|Ensembl:ENSSTOP00000018680};
GN   Name=KCND3 {ECO:0000313|Ensembl:ENSSTOP00000018680};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000018680, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000018680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000018680}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000018680}.
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DR   EMBL; AGTP01094599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01094600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01094601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01094602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01094603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01094604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005337678.1; XM_005337621.1.
DR   STRING; 43179.ENSSTOP00000018680; -.
DR   Ensembl; ENSSTOT00000029244; ENSSTOP00000018680; ENSSTOG00000001773.
DR   eggNOG; KOG4390; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00760000118846; -.
DR   InParanoid; I3N2T4; -.
DR   OMA; TNHEFID; -.
DR   OrthoDB; EOG091G0MQU; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR   GO; GO:0005250; F:A-type (transient outward) potassium channel activity; IEA:Ensembl.
DR   GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
DR   GO; GO:1902282; F:voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; IEA:Ensembl.
DR   GO; GO:0097623; P:potassium ion export across plasma membrane; IEA:Ensembl.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR   InterPro; IPR003975; K_chnl_volt-dep_Kv4.
DR   InterPro; IPR004056; K_chnl_volt-dep_Kv4.3.
DR   InterPro; IPR024587; K_chnl_volt-dep_Kv4_C.
DR   InterPro; IPR021645; Shal-type_N.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 4.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF11879; DUF3399; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF11601; Shal-type; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01518; KV43CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   PRINTS; PR01497; SHALCHANNEL.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00091688}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    655       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5011619870.
FT   TRANSMEM    181    202       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    255    276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    321    342       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    354    370       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    382    403       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       40    139       BTB. {ECO:0000259|SMART:SM00225}.
FT   COILED      137    157       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   655 AA;  73416 MW;  F5A1E6F35E8684FB CRC64;
     MAAGVAAWLP FARAAAIGWM PVANCPMPLA PADKNKRQDE LIVLNVSGRR FQTWRTTLER
     YPDTLLGSTE KEFFFNEDTK EYFFDRDPEV FRCVLNFYRT GKLHYPRYEC ISAYDDELAF
     YGILPEIIGD CCYEEYKDRK RENAERLMDD NDSENNQESM PSLSFRQTMW RAFENPHTST
     LALVFYYVTG FFIAVSVITN VVETVPCGTV PGSKELPCGE RYSVAFFCLD TACVMIFTVE
     YLLRLFAAPS RYRFIRSVMS IIDVVAIMPY YIGLVMTNNE DVSGAFVTLR VFRVFRIFKF
     SRHSQGLRIL GYTLKSCASE LGFLLFSLTM AIIIFATVMF YAEKGSSASK FTSIPASFWY
     TIVTMTTLGY GDMVPKTIAG KIFGSICSLS GVLVIALPVP VIVSNFSRIY HQNQRADKRR
     AQKKARLARI RVAKTGSSNA YLHSKRNGLL NEALELAGTP EEEHVGKTTS LIESQHHHLL
     HCLEKTTGLS YLVDDPLLSV RTSTIKNHEF IDEQMFEQNC MESSMQNYPS TRSPSLSSHP
     GLTTTCCSRR NKKTTHLPNS NLPATRLRSM QELSTIHIQG SEQPSLTTSR SSLNLKADDG
     LRPNCKTSQI TTAIISIPTP PALTPEGESR PPPASPGPNT NIPSIASNVV KVSAL
//
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