ID I3N497_ICTTR Unreviewed; 420 AA.
AC I3N497;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Mitochondrial ribosome associated GTPase 2 {ECO:0000313|Ensembl:ENSSTOP00000019193.2};
GN Name=MTG2 {ECO:0000313|Ensembl:ENSSTOP00000019193.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000019193.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000019193.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. OBG GTPase family. {ECO:0000256|ARBA:ARBA00007699}.
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DR EMBL; AGTP01038618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005325358.1; XM_005325301.2.
DR RefSeq; XP_013214090.1; XM_013358636.1.
DR AlphaFoldDB; I3N497; -.
DR STRING; 43179.ENSSTOP00000019193; -.
DR Ensembl; ENSSTOT00000026244.2; ENSSTOP00000019193.2; ENSSTOG00000024521.2.
DR GeneID; 101959423; -.
DR CTD; 26164; -.
DR GeneTree; ENSGT00940000157379; -.
DR HOGENOM; CLU_011747_2_3_1; -.
DR InParanoid; I3N497; -.
DR OrthoDB; 232786at2759; -.
DR TreeFam; TF314774; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0005761; C:mitochondrial ribosome; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0070129; P:regulation of mitochondrial translation; IEA:Ensembl.
DR GO; GO:0044065; P:regulation of respiratory system process; IEA:Ensembl.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd01898; Obg; 1.
DR Gene3D; 2.70.210.12; GTP1/OBG domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_01454; GTPase_Obg; 1.
DR InterPro; IPR031167; G_OBG.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR014100; GTP-bd_Obg/CgtA.
DR InterPro; IPR006169; GTP1_OBG_dom.
DR InterPro; IPR036726; GTP1_OBG_dom_sf.
DR InterPro; IPR045086; OBG_GTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR NCBIfam; TIGR02729; Obg_CgtA; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR11702; DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11702:SF31; MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2; 1.
DR Pfam; PF01018; GTP1_OBG; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF82051; Obg GTP-binding protein N-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51710; G_OBG; 1.
DR PROSITE; PS51883; OBG; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..420
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011573827"
FT DOMAIN 85..239
FT /note="Obg"
FT /evidence="ECO:0000259|PROSITE:PS51883"
FT DOMAIN 240..404
FT /note="OBG-type G"
FT /evidence="ECO:0000259|PROSITE:PS51710"
SQ SEQUENCE 420 AA; 45771 MW; 9470BE2B30CE21AB CRC64;
MSFWPSCCRR TCVGAMIPVR LFSASAQTLL EGLAQWTLSA QASLRSCRLL PQQASPRMLS
VGCVDHTKHQ ETPGKKPLSE KKLKRYFVDH RRVLVRGGNG GSGVSCFHSE PRKEFGGPDG
GDGGNGGHVI LRADQQVKSL SSVLSQYQGF SGEDGGRKNC FGRSGAMLFV RVPVGTLVKE
GSEVVADLSQ RGQEYIAALG GAGGKGNRFF LANDNRAPVT CTPGEPGQER VLHLELKTVA
HAGMVGFPNA GKSSLLRAIS NAKPAVASYP FTTLKPHVGI VHYEGHQQVA VADIPGIIRG
AHQDKGLGLS FLRHIERCRF LLFIVDLSLP EPWTQVEDLK YELEKYEEGL SERPHVVVAN
KIDLPQARAH LPQLQDHLGQ VIALSAVTGE NLEQLLLHLQ VLHRAYVEAE LKRGSQPLRW
//
