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Database: UniProt
Entry: I3N658_ICTTR
LinkDB: I3N658_ICTTR
Original site: I3N658_ICTTR 
ID   I3N658_ICTTR            Unreviewed;      1004 AA.
AC   I3N658;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   24-JAN-2024, entry version 68.
DE   SubName: Full=Neurofilament heavy {ECO:0000313|Ensembl:ENSSTOP00000019854.1};
GN   Name=NEFH {ECO:0000313|Ensembl:ENSSTOP00000019854.1};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000019854.1, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000019854.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; AGTP01087998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005336109.1; XM_005336052.2.
DR   AlphaFoldDB; I3N658; -.
DR   STRING; 43179.ENSSTOP00000019854; -.
DR   Ensembl; ENSSTOT00000020790.2; ENSSTOP00000019854.1; ENSSTOG00000027964.2.
DR   GeneID; 101965664; -.
DR   CTD; 4744; -.
DR   eggNOG; ENOG502QYDU; Eukaryota.
DR   GeneTree; ENSGT00940000161893; -.
DR   HOGENOM; CLU_012560_7_2_1; -.
DR   InParanoid; I3N658; -.
DR   OMA; FHSWTRT; -.
DR   OrthoDB; 4640531at2759; -.
DR   TreeFam; TF330122; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0030424; C:axon; IEA:Ensembl.
DR   GO; GO:0097418; C:neurofibrillary tangle; IEA:Ensembl.
DR   GO; GO:0005883; C:neurofilament; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0099160; C:postsynaptic intermediate filament cytoskeleton; IEA:Ensembl.
DR   GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0099184; F:structural constituent of postsynaptic intermediate filament cytoskeleton; IEA:Ensembl.
DR   GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0033693; P:neurofilament bundle assembly; IEA:Ensembl.
DR   GO; GO:0060052; P:neurofilament cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0048936; P:peripheral nervous system neuron axonogenesis; IEA:Ensembl.
DR   GO; GO:0099170; P:postsynaptic modulation of chemical synaptic transmission; IEA:Ensembl.
DR   GO; GO:1902513; P:regulation of organelle transport along microtubule; IEA:Ensembl.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR010790; DUF1388.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR033183; NF-H.
DR   PANTHER; PTHR23214:SF1; NEUROFILAMENT HEAVY POLYPEPTIDE; 1.
DR   PANTHER; PTHR23214; NEUROFILAMENT TRIPLET H PROTEIN; 1.
DR   Pfam; PF07142; DUF1388; 3.
DR   Pfam; PF00038; Filament; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          94..410
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          55..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          455..1004
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          98..132
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          175..223
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          294..381
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        459..503
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        504..1004
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1004 AA;  110061 MW;  F7D52462A298E770 CRC64;
     MMSFGGADAL LGAPFAPLHG GGSLHYALAR KGGSRSAAGS SSGFHSWTRT SVSSVSASPS
     RFRGAGAASS TDSLDTLSNG PEGCVVAAAA ARSEKEQLQA LNDRFAGYID KVRQLEAHNR
     SLEGEAAALR QQQAGRAAMG ELYEREVREM RGAVLRLGAA RGQLRLEQEH LLEDIAHVRQ
     RLDDEARQRE EAEAAARALA RFAQEAEAAR VELQKKAQAL QEECGYLRRH HQEEVGELLG
     QIQGCGAAQA QAQAEARDAL KCDVTSALRE IRAQLEGHAV QSTLQSEEWF RVRLDRLSEA
     AKVNTDAMRS AQEEITEYRR QLQARTTELE ALKSTKDSLE RQRSELEDRH QADIASYQEA
     IQQLDTELRN TKWEMAAQLR EYQDLLNVKM ALDIEIAAYR KLLEGEECRI GFGPSPFSLP
     EALPKIPSIS THIKVKSEEK IKVVEKSEKE TVIVEEQTEE IQVTEEVTEE EEKEAKEEEG
     KEEKEGEEEE AEEGEEEAES PPAEEAASPE KETKSPVKEE AKSPAEEKSP VKDEAKSPAE
     AKSPAKEEAK SPVEAKSPEK AKSPVKEEAK SPVEAKSPEK AKSPVKEEAK SPAEAKSPVK
     EEAKSPAEVK SPEKAKSPVK EEAKSPEKAK SPVKEEAKSP EKAKSPVKEE AKSPEKAKSP
     VKEEVKSPEK AKSPVKEEVK SPEKAKSPVK EEVKSPEKAK SPAKEEAKSP EKAKSPAKEE
     AKSPEKAKSP AKEEAKSPEK AKTLDVKSPE AKTPVKEEAR SPADIKSPDK AKSPVKEEAK
     SPEKVKSPEK EVPKKEEVKS PVKEEEKPKE SPKKAEEKAP ATPKTEEKDS KKDEALKKEA
     PKPQVEAKKE AAEKPKESKV EAKKEETEDK KKAATPEKEA PAKAEVKEEA KPKDKTEVPK
     KEAEPSKPAE KEPEKPKKEE AAAVPEKKDT KEEKTAEAKK PEEKPKTEAK AKEDDKGASK
     EPSKEAPTPS KPKTEKAEKS SSTDQKDSKP AEKATEDKAT KGEK
//
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