ID I3N658_ICTTR Unreviewed; 1004 AA.
AC I3N658;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE SubName: Full=Neurofilament heavy {ECO:0000313|Ensembl:ENSSTOP00000019854.1};
GN Name=NEFH {ECO:0000313|Ensembl:ENSSTOP00000019854.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000019854.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000019854.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AGTP01087998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005336109.1; XM_005336052.2.
DR AlphaFoldDB; I3N658; -.
DR STRING; 43179.ENSSTOP00000019854; -.
DR Ensembl; ENSSTOT00000020790.2; ENSSTOP00000019854.1; ENSSTOG00000027964.2.
DR GeneID; 101965664; -.
DR CTD; 4744; -.
DR eggNOG; ENOG502QYDU; Eukaryota.
DR GeneTree; ENSGT00940000161893; -.
DR HOGENOM; CLU_012560_7_2_1; -.
DR InParanoid; I3N658; -.
DR OMA; FHSWTRT; -.
DR OrthoDB; 4640531at2759; -.
DR TreeFam; TF330122; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0097418; C:neurofibrillary tangle; IEA:Ensembl.
DR GO; GO:0005883; C:neurofilament; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0099160; C:postsynaptic intermediate filament cytoskeleton; IEA:Ensembl.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0099184; F:structural constituent of postsynaptic intermediate filament cytoskeleton; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0033693; P:neurofilament bundle assembly; IEA:Ensembl.
DR GO; GO:0060052; P:neurofilament cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0048936; P:peripheral nervous system neuron axonogenesis; IEA:Ensembl.
DR GO; GO:0099170; P:postsynaptic modulation of chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:1902513; P:regulation of organelle transport along microtubule; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR010790; DUF1388.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR033183; NF-H.
DR PANTHER; PTHR23214:SF1; NEUROFILAMENT HEAVY POLYPEPTIDE; 1.
DR PANTHER; PTHR23214; NEUROFILAMENT TRIPLET H PROTEIN; 1.
DR Pfam; PF07142; DUF1388; 3.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 94..410
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 55..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 98..132
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 175..223
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 294..381
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 459..503
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..1004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1004 AA; 110061 MW; F7D52462A298E770 CRC64;
MMSFGGADAL LGAPFAPLHG GGSLHYALAR KGGSRSAAGS SSGFHSWTRT SVSSVSASPS
RFRGAGAASS TDSLDTLSNG PEGCVVAAAA ARSEKEQLQA LNDRFAGYID KVRQLEAHNR
SLEGEAAALR QQQAGRAAMG ELYEREVREM RGAVLRLGAA RGQLRLEQEH LLEDIAHVRQ
RLDDEARQRE EAEAAARALA RFAQEAEAAR VELQKKAQAL QEECGYLRRH HQEEVGELLG
QIQGCGAAQA QAQAEARDAL KCDVTSALRE IRAQLEGHAV QSTLQSEEWF RVRLDRLSEA
AKVNTDAMRS AQEEITEYRR QLQARTTELE ALKSTKDSLE RQRSELEDRH QADIASYQEA
IQQLDTELRN TKWEMAAQLR EYQDLLNVKM ALDIEIAAYR KLLEGEECRI GFGPSPFSLP
EALPKIPSIS THIKVKSEEK IKVVEKSEKE TVIVEEQTEE IQVTEEVTEE EEKEAKEEEG
KEEKEGEEEE AEEGEEEAES PPAEEAASPE KETKSPVKEE AKSPAEEKSP VKDEAKSPAE
AKSPAKEEAK SPVEAKSPEK AKSPVKEEAK SPVEAKSPEK AKSPVKEEAK SPAEAKSPVK
EEAKSPAEVK SPEKAKSPVK EEAKSPEKAK SPVKEEAKSP EKAKSPVKEE AKSPEKAKSP
VKEEVKSPEK AKSPVKEEVK SPEKAKSPVK EEVKSPEKAK SPAKEEAKSP EKAKSPAKEE
AKSPEKAKSP AKEEAKSPEK AKTLDVKSPE AKTPVKEEAR SPADIKSPDK AKSPVKEEAK
SPEKVKSPEK EVPKKEEVKS PVKEEEKPKE SPKKAEEKAP ATPKTEEKDS KKDEALKKEA
PKPQVEAKKE AAEKPKESKV EAKKEETEDK KKAATPEKEA PAKAEVKEEA KPKDKTEVPK
KEAEPSKPAE KEPEKPKKEE AAAVPEKKDT KEEKTAEAKK PEEKPKTEAK AKEDDKGASK
EPSKEAPTPS KPKTEKAEKS SSTDQKDSKP AEKATEDKAT KGEK
//