ID I3N777_ICTTR Unreviewed; 859 AA.
AC I3N777;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Adhesion G protein-coupled receptor D1 {ECO:0000313|Ensembl:ENSSTOP00000020223.2};
GN Name=ADGRD1 {ECO:0000313|Ensembl:ENSSTOP00000020223.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020223.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000020223.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGTP01088719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01088720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01088721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01088722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01088723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01088724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01088725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3N777; -.
DR Ensembl; ENSSTOT00000023996.2; ENSSTOP00000020223.2; ENSSTOG00000004009.3.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000159783; -.
DR HOGENOM; CLU_008509_0_0_1; -.
DR TreeFam; TF351999; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF216; ADHESION G-PROTEIN COUPLED RECEPTOR D1; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 554..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 589..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 771..794
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 551..795
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 819..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 859 AA; 93483 MW; 983E766AB263008A CRC64;
LASASHYWPL ETVDGIHELQ DTTGALQAHN LTVLPPHNST LVFANDSAYS NLSATVDIVE
GKVNKGIYLK EERGMTLLYY GRLRTSCISS PTQCGPEGVT FSFFWKTQEE QSRPIPSAYG
GQVISNGFKV CSIGGKGSVE LYTRENSMTW EATFSPPGPY WTHVLFTWKS KEGLKVYING
TLSTSDPSGK VSHAYGEPSA NLVIGSEQDQ TKRYENGAFD EFIIWERALT PDEVAMYFTA
AIGKHVLSTL APGTHTPTDA YHPIITNLTE EREHFQRPGV VLSYLYNVSR SLPSKSLSED
TALNLTETFL NTVGELLLLP SWTDVSEDSV LALGLIDTID TVMGHVSSNL HPSEPQVSLV
GSSSMADFSV AKVLPRTLGA PHYRFPAHGQ SYIQIPREAF CSPAWTTIVG LLYHSMHCYL
NNIHPASTEI AEAANCRTCL LSAASYLISL EVSPPPMVSQ NLSGSPLITI HLRHRLTHKQ
HIDATNASNR VFLYCAFLNF SSGGGVWSSQ GCARTEGNLS YSVCRCTHLT NFAILMQVVP
LELTRSHQVA LSSISYVGCS LSVLCLAATL VTFAALSSVS TIRNQRYHIH ANLSFAVLVA
QVLLLISFHA EPGTIPCQVL AMLLHYFFLS AFAWMLVEGL HLYSMVVKVF GSEDSKHLYY
YGLGWGSPLL ICIITIASAL DSYGTSDNCW LSLGSGAIWA FVAPALLVIM VNIGILVAVT
RVISQISADS YKIHGDPSAS KLTAKAVAVL LPILGTSWVF GVLAVNDGAL VFQYLFAILN
SLQGLFIFLF HCLLNSEVRA AFKHKTKVWS LVSSSARSAN TKPLSSDLMN GTRPGTGSTK
LSPWDKSSHS APRVDLSAV
//
