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Database: UniProt
Entry: I3N7G7_ICTTR
LinkDB: I3N7G7_ICTTR
Original site: I3N7G7_ICTTR 
ID   I3N7G7_ICTTR            Unreviewed;      1173 AA.
AC   I3N7G7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   22-NOV-2017, entry version 33.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 4 {ECO:0000313|Ensembl:ENSSTOP00000020313};
GN   Name=TRPM4 {ECO:0000313|Ensembl:ENSSTOP00000020313};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020313, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000020313}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000020313}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000020313}.
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DR   EMBL; AGTP01089694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01089695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01089696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01089697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000020313; -.
DR   Ensembl; ENSSTOT00000023117; ENSSTOP00000020313; ENSSTOG00000026855.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; I3N7G7; -.
DR   OMA; GQAPWSD; -.
DR   OrthoDB; EOG091G017C; -.
DR   TreeFam; TF314204; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0034706; C:sodium channel complex; IEA:Ensembl.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IEA:Ensembl.
DR   GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0002407; P:dendritic cell chemotaxis; IEA:Ensembl.
DR   GO; GO:0086045; P:membrane depolarization during AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086048; P:membrane depolarization during bundle of His cell action potential; IEA:Ensembl.
DR   GO; GO:0086047; P:membrane depolarization during Purkinje myocyte cell action potential; IEA:Ensembl.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0016925; P:protein sumoylation; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0002724; P:regulation of T cell cytokine production; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR   GO; GO:0042310; P:vasoconstriction; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029581; TRPM4.
DR   PANTHER; PTHR13800:SF6; PTHR13800:SF6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   1173 AA;  130038 MW;  B49C8FD6843D9640 CRC64;
     MVGPEKEQSW IPKIFRKKIC TTFIVDLSDS GGTLCQCGRP RSAHPSVAVE DAFGAAVVTV
     WDSDVHTTEK PTDAYGDLDF QGAGRRTSNF LRLSDRTDPA TVYSLVTRAW GFQAPNLVVS
     VLGGSSGPVL QTWLQDLLRR GLVRAAQSTG AWIVTGGLHT GIGRHVGVAV RDHQTASTGG
     TNVVAMGVAP WGVVRNRDSL TDPKGSFPAK YRWHGDPEDG VEFPLDYNYS AFFLVDDGTH
     GRLGGEDRFR LRFETYVSRQ KTGVGGTGID IPVLLLLIDG DEKMLKRIED ATEAQLPCLL
     VAGSGGAADC LAETLEDTLA PGSGGVRRGE AHDRIKRFFP KGDPEVLHAQ TIVLKALVKA
     CGTSEASAYL DELRLAVAWN RVDIAQSELF RGDIQWRSFH LEASLMDALL NDRPEFVRLL
     ISHGLSLGHF LTPTRLAQLY SAAPPHSLIR SLLDQASHWS GTKGQSLKGG SAELRLPNVG
     HVLRTLLGET CAPRYPSTDV RDPHTGQGCG ESACLLSDWA TLKPSMDAAF GQAPWSDLLL
     WALLLNRAQM AMYFWEKGTN AVASALGACL LLRVMARLEP EAEEAARRKD LAVKFEGMAV
     DLFGACYRSS EDRAARLLLR RCPLWGDATC LQLAMQADAR AFFAQDGVQS LLTQKWWGEM
     DSTTPIWALV LAFFCPPLIY ANLITFRNSE EESTQKDPDL DMGSGINGEG PKVAFALVSA
     CRMPREHGCL RHWSHFWGAP VTAFLGNVVS YLLFLLLFAH VLLLDFQPAA PGPAELLLYF
     WAFTLLCEEL RQGLGGGWGS LASGGPMPGQ TPLRHRLQLY LADTWNQCDL VALTCFLLGV
     GCRLTPGLYD LGRTVLCLDF MVFTLRLLHI FTVNKQLGPK IVIVSKMMKD VFFFLFFLGV
     WLVAYGVATE GLLRPRDRDL PNILRRVFYR PYLQIFGQIP QEDMDVALME HINCSSEQGA
     WARPLGRQAG SCVSLYANWL VVLLLIIFLL VANILLLNLL IAMFSYTFGK VQGNSDLYWK
     AQRYSLIREF HSRPALAPPL IIISHVRLLI RRLCRRRWAN LPSSPALKHF RVSLSKEDER
     ELMTWESVHK ENFLLAQARD KRESDSERLK RTSQKVDMAL KQLGQIREYE RRLKGLEREV
     QHCNRVLDWV AEALSRSALL PPGGPPPPTG PTG
//
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