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Database: UniProt
Entry: I3N7G7_ICTTR
LinkDB: I3N7G7_ICTTR
Original site: I3N7G7_ICTTR 
ID   I3N7G7_ICTTR            Unreviewed;      1212 AA.
AC   I3N7G7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   30-AUG-2017, entry version 31.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 4 {ECO:0000313|Ensembl:ENSSTOP00000020313};
GN   Name=TRPM4 {ECO:0000313|Ensembl:ENSSTOP00000020313};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020313, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000020313}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000020313}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000020313}.
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DR   EMBL; AGTP01089694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01089695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01089696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01089697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000020313; -.
DR   Ensembl; ENSSTOT00000023117; ENSSTOP00000020313; ENSSTOG00000026855.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; I3N7G7; -.
DR   OMA; GQAPWSD; -.
DR   OrthoDB; EOG091G017C; -.
DR   TreeFam; TF314204; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0034706; C:sodium channel complex; IEA:Ensembl.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IEA:Ensembl.
DR   GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0002407; P:dendritic cell chemotaxis; IEA:Ensembl.
DR   GO; GO:0086045; P:membrane depolarization during AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086048; P:membrane depolarization during bundle of His cell action potential; IEA:Ensembl.
DR   GO; GO:0086047; P:membrane depolarization during Purkinje myocyte cell action potential; IEA:Ensembl.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0016925; P:protein sumoylation; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0002724; P:regulation of T cell cytokine production; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR   GO; GO:0042310; P:vasoconstriction; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029581; TRPM4.
DR   PANTHER; PTHR13800:SF27; PTHR13800:SF27; 1.
DR   Pfam; PF00520; Ion_trans; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    688    708       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    772    799       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    887    907       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    927    944       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1012   1037       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      786   1048       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1155   1182       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1212 AA;  133802 MW;  5F7739666751FED2 CRC64;
     MVGPEKEQSW IPKIFRKKIC TTFIVDLSDS GGTLCQCGRP RSAHPSVAVE DAFGAAVVTV
     WDSDVHTTEK PTDAYGDLDF QGAGRRTSNF LRLSDRTDPA TVYSLVTRAW GFQAPNLVVS
     VLGGSSGPVL QTWLQDLLRR GLVRAAQSTG AWIVTGGLHT GIGRHVGVAV RDHQTASTGG
     TNVVAMGVAP WGVVRNRDSL TDPKGSFPAK YRWHGDPEDG VEFPLDYNYS AFFLVDDGTH
     GRLGGEDRFR LRFETYVSRQ KTGVGGTGID IPVLLLLIDG DEKMLKRIED ATEAQLPCLL
     VAGSGGAADC LAETLEDTLA PGSGGVRRGE AHDRIKRFFP KGDPEVLHAQ MGRGWGPGLL
     GPGVGGRGTD SSTIVLKALV KACGTSEASA YLDELRLAVA WNRVDIAQSE LFRGDIQWRS
     FHLEASLMDA LLNDRPEFVR LLISHGLSLG HFLTPTRLAQ LYSAAPPHSL IRSLLDQASH
     WSGTKGQSLK GGSAELRLPN VGHVLRTLLG ETCAPRYPST DVRDPHTGQG CGESACLLSD
     WATLKPSMDA AFGQAPWSDL LLWALLLNRA QMAMYFWEKG TNAVASALGA CLLLRVMARL
     EPEAEEAARR KDLAVKFEGM AVDLFGACYR SSEDRAARLL LRRCPLWGDA TCLQLAMQAD
     ARAFFAQDGV QSLLTQKWWG EMDSTTPIWA LVLAFFCPPL IYANLITFRN SEEESTQKDP
     DLDMGSGING EGPVGPKDAP EKVPLGGQRQ PRSRGCCGGC ARHGCLRHWS HFWGAPVTAF
     LGNVVSYLLF LLLFAHVLLL DFQPAAPGPA ELLLYFWAFT LLCEELRQGL GGGWGSLASG
     GPMPGQTPLR HRLQLYLADT WNQCDLVALT CFLLGVGCRL TPGLYDLGRT VLCLDFMVFT
     LRLLHIFTVN KQLGPKIVIV SKMMKDVFFF LFFLGVWLVA YGVATEGLLR PRDRDLPNIL
     RRVFYRPYLQ IFGQIPQEDM DVALMEHINC SSEQGAWARP LGRQAGSCVS LYANWLVVLL
     LIIFLLVANI LLLNLLIAMF SYTFGKVQGN SDLYWKAQRY SLIREFHSRP ALAPPLIIIS
     HVRLLIRRLC RRRWANLPSS PALKHFRVSL SKEDERELMT WESVHKENFL LAQARDKRES
     DSERLKRTSQ KVDMALKQLG QIREYERRLK GLEREVQHCN RVLDWVAEAL SRSALLPPGG
     PPPPTGPTGH RD
//
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