ID I3N7W6_ICTTR Unreviewed; 3852 AA.
AC I3N7W6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=Ankyrin 2 {ECO:0000313|Ensembl:ENSSTOP00000020462.2};
GN Name=ANK2 {ECO:0000313|Ensembl:ENSSTOP00000020462.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020462.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000020462.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AGTP01060620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01060621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01060622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01060623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01060624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01060625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01060626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01060627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01060628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01060629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSSTOT00000025842.2; ENSSTOP00000020462.2; ENSSTOG00000001648.3.
DR GeneTree; ENSGT00940000155279; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08804; Death_ank2; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24178:SF33; ANKYRIN-2; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 22.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 19.
DR PROSITE; PS50088; ANK_REPEAT; 19.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 52..84
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 85..117
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 118..150
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 221..253
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 254..286
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 287..319
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 320..352
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 353..385
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 386..418
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 419..451
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 452..484
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 485..517
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 518..550
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 551..583
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 584..616
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 617..649
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 650..682
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 683..715
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 716..748
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 924..1079
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1081..1227
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 3412..3496
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1562..2033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2097..2298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2317..2396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2414..2751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2776..2805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2819..2865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2911..2942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2979..3025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3057..3304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3529..3714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3823..3852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1570..1606
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1624..1651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1678..1717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1718..1805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1871..1885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1908..1942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1943..1958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1973..2023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2129..2159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2161..2176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2196..2210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2211..2230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2330..2357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2375..2396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2414..2433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2441..2482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2494..2510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2534..2566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2576..2618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2626..2647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2648..2671
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2733..2750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2844..2859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2914..2942
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2998..3012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3073..3106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3107..3122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3136..3150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3203..3233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3234..3258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3286..3301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3532..3554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3561..3634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3641..3657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3690..3711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3852 AA; 422794 MW; 30BC1947815E4530 CRC64;
MFSLYPSLTE VFSSTPQSDS NASFLRAARA GNLDKVVEYL KGGIDINTCN QNGLNALHLA
AKEGHVGLVQ ELLGRGSSVD SATKKGNTAL HIASLAGQAE VVKVLVKEGA NINAQSQNGF
TPLYMAAQEN HIDVVKYLLE NGANQSTATE DGFTPLAVAL QQGHNQAVAI LLENDTKGKV
RLPALHIAAR KDDTKSAALL LQNDHNADVQ SKMMVNRTTE SGFTPLHIAA HYGNVNVATL
LLNRGAAVDF TARNGITPLH VASKRGNTNM VKLLLDRGGQ IDAKTRDGLT PLHCAARSGH
DQVVELLLER GAPLLARTKN GLSPLHMAAQ GDHVECVKHL LQHKAPVDDV TLDYLTALHV
AAHCGHYRVT KLLLDKRANP NARALNGFTP LHIACKKNRI KVMELLVKYG ASIQAITESG
LTPIHVAAFM GHLNIVLLLL QNGASPDVTN IRGETALHMA ARAGQVEVVR CLLRNGALVD
ARAREEQTPL HIASRLGKTE IVQLLLQHMA HPDAATTNGY TPLHISAREG QVDVASVLLE
AGAVHSLATK KGFTPLHVAA KYGSLDVAKL LLQRRAAADS AGKNGYTPLH IAAKKNQMQI
ASTLLNYGAE TNIVTKQGVT PLHLASQEGH TDMVTLLLEK GANIHMSTKS GLTSLHLAAQ
EDKVNVAEIL TKHGADQDAH TKLGYTPLIV ACHYGNVKMV NFLLKQGANV NAKTKNGYTP
LHQAAQQGHT HIINVLLQHG AKPNATTANG NTALAIAKRL GYISVVDTLK VVTEEVTTTT
TTITEKHKLN VPETMTEVLD VSDEEGDDTM TGDGGEYLRP EDLKELGDDS LPSSQFLDGM
NYLRYSLEGG RSDSLRSFSS DRSHTLSHAS YLRDSAMIDD TVVIPSHQVS TLAKEAERNS
YRLSWGTENL DNVALSSSPI HSGFLVSFMV DARGGAMRGC RHNGLRIIIP PRKCTAPTRV
TCRLVKRHRL ATMPPMVEGE GLASRLIEVG PSGAQFLGPV IVEIPHFAAL RGKERELVVL
RSENGDSWKE HFCEYTEDEL NEILNGMDEV LDSPEDLEKK RICRIITRDF PQYFAVVSRI
KQDSNLIGPE GGVLSSTVVP QVQAVFPEGA LTKRIRVGLQ AQPMHSELVK KILGNKATFS
PIVTLEPRRR KFHKPITMTI PVPKASSDVM LNGFGGDAPT LRLLCSITGG TTPAQWEDIT
GTTPLTFVNE CVSFTTNVSA RFWLIDCRQI QESVTFASQV YREIICVPYM AKFVVFAKSH
DPIEARLRCF CMTDDKVDKT LEQQENFAEV ARSRDVEVLE GKPIYVDCFG NLVPLTKSGQ
HHIFSFFAFK ENRLPLFVKV RDTTQEPCGR LSFMKEPKST RGLVHQAICN LNITLPIYMK
ESESDQEQEE ETESTETSVL KSHLVNEVPV LASPDLLSEV SEMKQDLIKM TAILTTDVSD
KAGSIKVKEL VKAAEEEPGE PFEIVERVKE DLEKVNEILR SGTCSREESS VQSSAQSEKE
LVEEGWVIVS DEEIEEARQK APLEITEYPC VEVRLEKETK AQVEKDATGL VNYLVEDLNS
YVSPHGEKPQ TGHDVAREKS EAPSVGKSSE KEGKAAPPDE KQGLQKPHKP TLGIKKPVRR
KLKEKQKQKE ESINASEDKS EVKKGSSEES LDEDAGLAPE SLPTVKATSP LIEETPIGSI
KDKVKALQKR VEDEQKGRSK LPIRVKGKED VPKKTTHRTH PTASPSLKTD RHSPLSSSAK
NERHPPVSPS SKTEKHSPVS PSAKTERHSP VLSSGKTEKH SPVSPSTKAE RHSPVSSTKT
ERHPPVSPST KTDKRPPVSP SGRTEKHPPV SPGRTEKRLP VSPSGRTEKH PPVSTAAKTE
KHLPVSPSGK TEKQPPVSPT SKTERIEETM SVRELMKAFQ SGQDPSKHKT GLFEHKSAKQ
KPSQEKGKAA RVEKEKGQTA TLKETQRTET QTIKRGQRFL VTGASESRRG VRTSSIGFKK
EDAVGEKEKA PSPKTPEPVH SAPEEESHRE KKMVDEQGDM DLQISPDRKT STDFSDVIKQ
ELEDNDKYQQ FRMSEGTEKA QLHLDQVLTS PFNTTFPLDY MKDEFLPALS LQSDALDASS
ESLKQEGMAG SPCGSLMEGT PQISSEESYK HEGLAETPET SPEREEHHPT KDITDEPSKD
ISPQPEGSSS VSLAKETPKA LTDEGQLTLD SSAHKTPTDG EARESPDETK SSPLTDASVK
TDTGIASKPQ GGMRSPQGLE LALPSRDSEV LSPMADESLA TPDSLEPSPL KESPCRDSLE
SSPVEPKMKA GILPSHFPLP SAVTKTELVT EVASMRSRLL RDPDGSAEDD SLEQTSLMES
SGKSPLSPDT PSSEEVSYEV TPKAADTSTP KPAVIHECAE EDDSENGEKK RFTPEEEMFK
MVTKIKMFDE LEQEAKQKRD YKKEPKQEES SSSSDPDADC SADVDEPKQV DEPKQVDEPK
QVDEPKQVDE PKQVDEPKQM ENMAGESHVP VLVTSESRKA SSSSDSEPEL TQLKKGADSG
LLPEPVIRVQ PPSPLPSSID SNSSPEEVQF QPIVSKQYTF KMNEDTQEEP GNSEEEKDCE
SPLADDSHPF STDDADRTYD ADRTYDDLSR DTDQPKVCDG HGCEAVSPTC STTPISSGLQ
NSAGDDVDEQ LVTHKESFAP QDTHENDPGE ELDAPAVESP QRECPSDSYS SLSPLPHCPE
SEGKELDDDL SSTSSTTKVE VTKTDETLEN IPKDYSTQDS SITTQTDRFP MDVPVSDLAE
TGEIYDPHVI SPYENVPTQS FFSSEESKTQ TGTSHTSSDY SSEVYSVTTS SVEDVLVTSS
SSATVSSKES NLEGQHLEIE SRQESTLWEM QSDRASSLEP GVPSTPAVIS EQISKVIITK
TDVDSDSWSE IREDDEAFEA RVKEEEQKIF GLMVDRQSQG TTPDTTPART PTEEGTPTSE
QNPFLFQEGK LFEMTRSGAI DMTKRSYADE SFHFFQIGQE SRDDTLSEDM KEGVTGAEPQ
QLESTAESLA LSESKETVDD EGELLPDDLS EEVEEISASD THLNSQMGIS VCMEPSTKEA
IATGAEDLPT MQRGDTPSPS NVKQTPCSDS PEPVVQVQLD FSTVTRSVYS DRDDDSPDSS
PEEQKSVIEI PTAPMENVPS TESKSKIPVR TIPTSIPEPP SVEDESTFSE DVLSSLDEES
KEDEAKPKSK IPIKAPIQRV EQSLSHLGAS LQQSVAPQGQ DVTSRTPDNR SQSESDVSPE
DSKTKCPVKA RSDTETETES REGAEELELE SEEGATGPKI FASRLPVKSR STTSSCRGGM
SPTKESKEHF FDLYRNSIEF FEEISDEASK LVDRLTQSER EQELVSDDES SSALEVSVIE
NLPPVETEHS VPEDIFDTRP IWDESIETLI ERIPDENGHD HAEDPQDEQE RIEERLAYIA
DHLGFSWTEL ARELDFTEEQ IHQIRIENPN SLQDQSHALL KYWLERDGKH ATDTNLIECL
TKINRMDIVH LMETSTEPLQ ERISHSYAEI EQTITLDHSE GFSVLQEELS AAQHKQSEEQ
ALSKESESSD HPPIVSEEDI SVGYSTFQDS IPKTEGDSAT TVLSPQTHKE QVQQDFSGKM
QDLPEDNVTT PGTEGSETHK ATAEPGSPSK TPEEISTPPE EERQYLQTPT SSERGGSPIV
QEPEELPEPR EEGSPRKTSL VIVESADDQA QTVERLDGDA TFDKGDDMPD IPPETVTEEE
YIDEHGHTVV KKVTRKIIRR YVSSDGTEKE EITMQGMPQE PVTIQEGDGY SKVIKRVVLK
SDIEQSEVTL SEPSILSSAS QFQAEPVEGR RVSKVIKTTM VRGERMEKHL GDSSLATDLP
SAKDDFEEDN HE
//