ID I3NBE5_ICTTR Unreviewed; 750 AA.
AC I3NBE5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365};
DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728};
GN Name=MPEG1 {ECO:0000313|Ensembl:ENSSTOP00000021692.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000021692.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000021692.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome
CC membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004265}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MPEG1 family.
CC {ECO:0000256|ARBA:ARBA00007256}.
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DR EMBL; AGTP01066929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01066930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01066931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3NBE5; -.
DR STRING; 43179.ENSSTOP00000021692; -.
DR Ensembl; ENSSTOT00000015749.3; ENSSTOP00000021692.2; ENSSTOG00000015747.3.
DR eggNOG; ENOG502QRKR; Eukaryota.
DR GeneTree; ENSGT00390000008048; -.
DR HOGENOM; CLU_023578_1_0_1; -.
DR InParanoid; I3NBE5; -.
DR OrthoDB; 4221421at2759; -.
DR TreeFam; TF331165; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0061474; C:phagolysosome membrane; IEA:Ensembl.
DR GO; GO:0022829; F:wide pore channel activity; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR CDD; cd22579; MPEG1_P2; 1.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR039707; MPEG1.
DR PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00023130};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 689..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..380
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
SQ SEQUENCE 750 AA; 82646 MW; BDACCBF7422EB8F3 CRC64;
MRRNKLLNSL SSGQLTPVCS LAAASSWCGA GAVSTMSSFR AAFVFWAVVA CARTDPPLEE
KEETGVQRCK NALKIPVLEV LPGGGWDNLR NVDMGRVIEL NYTHCRTTED GQYIIPDEVF
TIPQKQSNLD LNSEILESWM NYKSSISSSI NMEISVFSKV NGKFSTEFQR LKTLQVRDKA
ATTRVQVRNL IYTVKIDPAS RLSSGFMKDL MDISDFLANN QTRMATYLAE LLVLNYGTHV
ITSLEAGAIL MQEDHIKSSF LRDSQSNHVG VTASAGVSFL NTVNFEASVN VTYQDDLTKS
YLANRTNSRV QSIGGVPFYP GITLQTWQQS TTNHLVAIDR AGLPLHFFIK PNTLPQLPGP
LVNKLSQTVE TAVRQYYNFN TYPGCTDINS PNFNFHANTD DGSCEGKMTN FSFGGIYQEC
TPLTGSKSAF LCQKLQQKNP LTGDFSCPAG YSAVHLLTQV YEEGYSQLEC KENCYLVIFC
STVCEDVFQK SKVQFRVFWC MVKDQVPANS GLLFGGLFSS KSVNPMTNAQ SCPVGYIPVT
LFTSLSVCVS LDYEMGHKFS VPFGGFFSCA VGNPLLKSSI STDGVPSLKK CPEGFSQHLA
IISDGCQVSY CIKAGVFTGG SLPPARLPPF TRPPLLSQST NTVLVTNREI SRSWIRDSKT
HRWRLGEPLE LRRVIKVIHG NSEGLSGGAT AGITVGVTTV LAAVIALAIY GTRKYKRREY
QLFEEERRNL TSEILPPEDF PASELQQSPA
//
