ID I3NDK8_ICTTR Unreviewed; 637 AA.
AC I3NDK8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Plastin 1 {ECO:0000313|Ensembl:ENSSTOP00000022455.2};
GN Name=PLS1 {ECO:0000313|Ensembl:ENSSTOP00000022455.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000022455.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000022455.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01051993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3NDK8; -.
DR STRING; 43179.ENSSTOP00000022455; -.
DR Ensembl; ENSSTOT00000023359.2; ENSSTOP00000022455.2; ENSSTOG00000009305.3.
DR GeneTree; ENSGT00950000183097; -.
DR HOGENOM; CLU_015284_2_0_1; -.
DR InParanoid; I3NDK8; -.
DR OrthoDB; 5475188at2759; -.
DR TreeFam; TF300680; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005903; C:brush border; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032420; C:stereocilium; IEA:Ensembl.
DR GO; GO:1990357; C:terminal web; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0051017; P:actin filament bundle assembly; IEA:InterPro.
DR GO; GO:0060088; P:auditory receptor cell stereocilium organization; IEA:Ensembl.
DR GO; GO:0001951; P:intestinal D-glucose absorption; IEA:Ensembl.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0032532; P:regulation of microvillus length; IEA:Ensembl.
DR GO; GO:1902896; P:terminal web assembly; IEA:Ensembl.
DR GO; GO:0060121; P:vestibular receptor cell stereocilium organization; IEA:Ensembl.
DR CDD; cd21323; CH_PLS1_rpt1; 1.
DR CDD; cd21332; CH_PLS1_rpt4; 1.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039959; Fimbrin/Plastin.
DR PANTHER; PTHR19961; FIMBRIN/PLASTIN; 1.
DR PANTHER; PTHR19961:SF27; PLASTIN-1; 1.
DR Pfam; PF00307; CH; 4.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00033; CH; 4.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 2.
DR PROSITE; PS50021; CH; 4.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 11..46
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 51..86
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 122..238
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 266..377
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 403..512
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 524..633
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
SQ SEQUENCE 637 AA; 71419 MW; 1E736853B494E633 CRC64;
MENSTTTISR EELEELQEAF NKIDIDNSGY VSDYELQDLF KEASLPLPGY KVREIVEKIL
AVTDNNKDGK ISFEEFVSLM QELKSKDISK TFRKIINKRE GITAIGGTSS ISSEGTQHSY
SEEEKVAFVN WINKALENDP DCKHLIPMNP NDDSLFTSLA DGILLCKMIN LSEPDTIDER
AINKKKLTPF TVSENLNLAL NSASAIGCTV VNIGAQDLKE GKPHLVLGLL WQIIKVGLFA
DIEISRNEAL IALLNEGEEL EELMKLSPEE LLLRWVNYHL TNAGWRTISN FSQDIKDSRA
YFHLLNQIAP KGDRENGTAI AIDLSGFNER NDLKRAEFML QEADKLGCRQ FVTPADVVSG
NPKLNLAFVA NLFNTYPCLH KPDNNDIDIN LLEDLTPPNV GESKEERTFR NWMNSLGVNP
YINHLYSDLA DALVIFQLYE MIRVPVDWSH VNKPPYPALG GNMKKIENCN YAVELGKNKA
KFSLVGIAGQ DLNEGNSTLT LALVWQLMRR YTLNVLSDLG EGEKVNDEII IKWVNQTLKS
ANKNTSISSF KDKSISTSLP VLDLIDAIAP NAVRQEMIKR ENLSDEDKLN NAKYAISVAR
KIGARIYALP DDLVEVKPKM VMTVFACLMG KGLNRIK
//
