ID I3NFN0_ICTTR Unreviewed; 242 AA.
AC I3NFN0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=RUNX family transcription factor 3 {ECO:0000313|Ensembl:ENSSTOP00000023177.2};
GN Name=RUNX3 {ECO:0000313|Ensembl:ENSSTOP00000023177.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000023177.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000023177.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AGTP01007650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01007651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01007652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01007653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01007654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3NFN0; -.
DR Ensembl; ENSSTOT00000020162.2; ENSSTOP00000023177.2; ENSSTOG00000022471.2.
DR eggNOG; KOG3982; Eukaryota.
DR GeneTree; ENSGT00940000156598; -.
DR HOGENOM; CLU_032910_1_0_1; -.
DR TreeFam; TF321496; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 2.60.40.720; -; 1.
DR InterPro; IPR000040; AML1_Runt.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
DR InterPro; IPR013524; Runt_dom.
DR PANTHER; PTHR11950; RUNT RELATED; 1.
DR PANTHER; PTHR11950:SF43; RUNT-RELATED TRANSCRIPTION FACTOR 3; 1.
DR Pfam; PF00853; Runt; 1.
DR PRINTS; PR00967; ONCOGENEAML1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS51062; RUNT; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 41..169
FT /note="Runt"
FT /evidence="ECO:0000259|PROSITE:PS51062"
FT REGION 194..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 242 AA; 26487 MW; FD2B033C89547872 CRC64;
MASNSIFDSF PTYSPTFVRG GALSAQAAVG PGGRARPEVR SMVDVLADHA GELVRTDSPN
FLCSVLPSHW RCNKTLPVAF KVVALGDVPD GTVVTVMAGN DENYSAELRN ASAVMKNQVA
RFNDLRFVGR SGRGKSFTLT ITVFTNPTQV ATYHRAIKVT VDGPREPRRH RQKIEDQTKA
FPDRFGDLER LRMRVTPSTP SPRGSLTTTT HFGSQGQTPI QGTSELTPFS DPRQFDRSFS
AL
//
