ID   I3NFS1_ICTTR            Unreviewed;       585 AA.
AC   I3NFS1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Spermine oxidase {ECO:0000313|Ensembl:ENSSTOP00000023218.1};
GN   Name=SMOX {ECO:0000313|Ensembl:ENSSTOP00000023218.1};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000023218.1, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000023218.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; AGTP01017758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005320562.1; XM_005320505.2.
DR   AlphaFoldDB; I3NFS1; -.
DR   STRING; 43179.ENSSTOP00000023218; -.
DR   Ensembl; ENSSTOT00000024844.2; ENSSTOP00000023218.1; ENSSTOG00000019673.2.
DR   GeneID; 101960258; -.
DR   CTD; 54498; -.
DR   eggNOG; KOG0685; Eukaryota.
DR   GeneTree; ENSGT00940000157511; -.
DR   HOGENOM; CLU_004498_2_3_1; -.
DR   InParanoid; I3NFS1; -.
DR   OMA; EIMLLWE; -.
DR   OrthoDB; 2642916at2759; -.
DR   TreeFam; TF318348; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0046592; F:polyamine oxidase activity; IEA:Ensembl.
DR   GO; GO:0046208; P:spermine catabolic process; IEA:Ensembl.
DR   Gene3D; 3.90.660.10; -; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR   PANTHER; PTHR10742:SF416; SPERMINE OXIDASE; 1.
DR   Pfam; PF01593; Amino_oxidase; 2.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          34..268
FT                   /note="Amine oxidase"
FT                   /evidence="ECO:0000259|Pfam:PF01593"
FT   DOMAIN          309..574
FT                   /note="Amine oxidase"
FT                   /evidence="ECO:0000259|Pfam:PF01593"
FT   REGION          272..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          503..523
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..290
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        506..523
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   585 AA;  64993 MW;  2E29F813C5494578 CRC64;
     MQSCESSGDS ADDPLSRGLR RRGQPRVVVI GAGLAGLAAA KALLEQGFTD VTVLEASSRI
     GGRVQSVKLG HATFELGATW IHGSQGNPVY HLAEANGLLE ETTDGERSVG RISLYSKNGV
     ACYLTNRGRR IPKDVVEEFS DLYNEVYNLT QEFFRHGKPV NAESQNSVGV FTREEVRNRI
     RDDPDDPEAT KRLKLAMIQQ YLKVESCESS SHSIDEVSLS AFGEWTEIPG AHHIIPSGFM
     RVVELLAEGI PSHVIQLGKP VRCIHWDQAS ARPRGPEIEP RVEGDHNHDT GEVGQSGVGP
     QGGRWDEDEQ WPVMVECEDC EVIPADHVIV TVSLGVLKRQ YTSFFQPGLP AEKVAAIHRL
     GIGTTDKIFL EFEEPFWGPE CNSLQFVWED EAESRTLTYP PELWYRKICG FDVLYPPERY
     GHVLSGWICG EEALVMEKCD DEAVAEICTE MLRQFTGNPN IPKPRRILRS AWGSNPYFRG
     SYSYTQVGSS GADVEKLAKP LPYTESSKTA HGSTTKQQPA HLLSSKCPEQ SLDLDRGSIK
     PMQVLFSGEA THRKYYSTTH GALLSGQREA ARLIEMYRDL FQQGT
//