ID I3NH19_ICTTR Unreviewed; 423 AA.
AC I3NH19;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Septin {ECO:0000256|PIRNR:PIRNR006698};
GN Name=SEPTIN6 {ECO:0000313|Ensembl:ENSSTOP00000023666.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000023666.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000023666.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Filament-forming cytoskeletal GTPase.
CC {ECO:0000256|PIRNR:PIRNR006698}.
CC -!- SUBUNIT: Septins polymerize into heterooligomeric protein complexes
CC that form filaments. {ECO:0000256|PIRNR:PIRNR006698}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|PIRNR:PIRNR006698, ECO:0000256|RuleBase:RU004560}.
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DR EMBL; AGTP01013331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01013332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01013333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01013334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3NH19; -.
DR Ensembl; ENSSTOT00000020640.2; ENSSTOP00000023666.2; ENSSTOG00000011593.3.
DR GeneTree; ENSGT00940000158026; -.
DR HOGENOM; CLU_017718_3_0_1; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF55; SEPTIN-6; 1.
DR Pfam; PF00735; Septin; 1.
DR PIRSF; PIRSF006698; Septin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006698};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR006698};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004560};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 35..301
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT REGION 401..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 317..395
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 423 AA; 48370 MW; 82587565976006AE CRC64;
LVRGLIGEGC RTVPLAGHVG FDSLPDQLVN KSVSQGFCFN ILCVGETGLG KSTLMDTLFN
TKFEGEPATH TQPGVQLRSN TYDLQESNVG LKLTIVSTVG FGDQINKEDS YKPIVEFIDA
QFEAYLQEEL KIRRVLHTYH DSRIHACLYF IAPTGHSLKS LDLVTMKKLD SKVNIIPIIA
KSDAISKSEL TKFKIKITSE LVSNGVQIYQ FPTDDESVAE INGTMNAHLP FAVIGSTEEL
KIGNKMMKAR QYPWGTVQVE NEAHCDFVKL REMLIRVNME DLREQTHTRH YELYRRCKLE
EMGFKDTDPD SKPFSLQETY EAKRNEFLGE LQKKEEEMRQ MFVQRVKEKE AELKEAEKEL
HEKFDRLKKL HQDEKKKLED KKKSLDDEVN AFKQRKTAAE LLQSQGSQAG GSQTLKRDKE
KKK
//
