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Database: UniProt
Entry: I3QJ35_PRRSV
LinkDB: I3QJ35_PRRSV
Original site: I3QJ35_PRRSV 
ID   I3QJ35_PRRSV            Unreviewed;      1460 AA.
AC   I3QJ35;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   24-JAN-2024, entry version 60.
DE   RecName: Full=Replicase polyprotein 1ab {ECO:0000256|ARBA:ARBA00022087};
DE   AltName: Full=ORF1ab polyprotein {ECO:0000256|ARBA:ARBA00029611};
DE   Flags: Fragment;
OS   Porcine reproductive and respiratory syndrome virus (PRRSV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Arnidovirineae; Arteriviridae; Variarterivirinae;
OC   Betaarterivirus; Ampobartevirus; Betaarterivirus suid 2.
OX   NCBI_TaxID=28344 {ECO:0000313|EMBL:AFK09172.1, ECO:0000313|Proteomes:UP000168363};
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1] {ECO:0000313|EMBL:AFK09172.1, ECO:0000313|Proteomes:UP000168363}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10-LW2-6 {ECO:0000313|EMBL:AFK09172.1};
RX   PubMed=22525010; DOI=10.1016/j.vetmic.2012.02.036;
RA   Yu X., Chen N., Wang L., Wu J., Zhou Z., Ni J., Li X., Zhai X., Shi J.,
RA   Tian K.;
RT   "New genomic characteristics of highly pathogenic porcine reproductive and
RT   respiratory syndrome viruses do not lead to significant changes in
RT   pathogenicity.";
RL   Vet. Microbiol. 158:291-299(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region
CC       {ECO:0000256|ARBA:ARBA00004407}. Host membrane
CC       {ECO:0000256|ARBA:ARBA00004301}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004301}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; JQ663563; AFK09172.1; -; Genomic_RNA.
DR   Proteomes; UP000168363; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   CDD; cd21410; 1B_av_Nsp10-like; 1.
DR   CDD; cd23189; Arteriviridae_RdRp; 1.
DR   CDD; cd17937; DEXXYc_viral_SF1-N; 1.
DR   CDD; cd21160; NendoU_av_Nsp11-like; 1.
DR   CDD; cd21166; NTD_av_Nsp11-like; 1.
DR   CDD; cd18786; SF1_C; 1.
DR   CDD; cd21405; ZBD_av_Nsp10-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR   InterPro; IPR046440; AV_NSP11N_COV_NSP15M.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR037227; EndoU-like.
DR   InterPro; IPR043609; NendoU_nidovirus.
DR   InterPro; IPR044863; NIRAN.
DR   InterPro; IPR044348; NSP10_1B_Av.
DR   InterPro; IPR027355; NSP10_Av_ZBD.
DR   InterPro; IPR044320; NSP11_Av_N.
DR   InterPro; IPR044314; NSP11_NendoU_Av.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001205; RNA-dir_pol_C.
DR   InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR   Pfam; PF19215; CoV_NSP15_C; 1.
DR   Pfam; PF00680; RdRP_1; 1.
DR   Pfam; PF01443; Viral_helicase1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF142877; EndoU-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51961; AV_NSP11N_COV_NSP15M; 1.
DR   PROSITE; PS51652; AV_ZBD; 1.
DR   PROSITE; PS51958; NENDOU; 1.
DR   PROSITE; PS51947; NIRAN; 1.
DR   PROSITE; PS51657; PSRV_HELICASE; 1.
DR   PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Endonuclease {ECO:0000256|PROSITE-ProRule:PRU01303};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01303}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00985}; Nuclease {ECO:0000256|PROSITE-ProRule:PRU01303};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Protease {ECO:0000256|ARBA:ARBA00022825};
KW   Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW   Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00985};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00985}.
FT   DOMAIN          1..150
FT                   /note="NiRAN"
FT                   /evidence="ECO:0000259|PROSITE:PS51947"
FT   DOMAIN          389..523
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50507"
FT   DOMAIN          644..707
FT                   /note="AV ZBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51652"
FT   DOMAIN          764..1045
FT                   /note="(+)RNA virus helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51657"
FT   DOMAIN          1084..1180
FT                   /note="AV-Nsp11N/CoV-Nsp15M"
FT                   /evidence="ECO:0000259|PROSITE:PS51961"
FT   DOMAIN          1182..1304
FT                   /note="NendoU"
FT                   /evidence="ECO:0000259|PROSITE:PS51958"
FT   ACT_SITE        1213
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01303"
FT   ACT_SITE        1228
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01303"
FT   ACT_SITE        1257
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01303"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFK09172.1"
SQ   SEQUENCE   1460 AA;  161560 MW;  1ADFFA37A3C01E4F CRC64;
     FKLLAASGLT RCGRGGLVVT ETAVKIVKFH NRTFTLGPVN LKVASEVELK DAVEHNQHPV
     ARPVDGGVVL LRSAVPSLID VLISGADASP KLLARHGPGN TGIDGTLWDF EAEATKEEVA
     LSAQIIQACD IRRGDAPEIG LPYKLHPVRG NPERVKGVLQ NTRFGDIPYK TPSDTGSPVH
     AAACLTPNAT PVTDGRSVLA TTMPSGFELY VPTIPASVLD YLDSRPDCPK QLTEHGCEDA
     ALRDLSKYDL STQGFVLPGV LRLVRKYLFA HVGKCPPVHR PSTYPAKNSM AGINGNRFPT
     KDIQSVPEID VLCAQAVREN WQTVTPCTLK KQYCGKKKTR TILGTNNFIA LAHRAALSGV
     TQGFMKKAFN SPIALGKNKF KELQAPVLGR CLEADLASCD RSTPAIVRWF AANLLYELAC
     AEEHLPSYVL NCCHDLLVTQ SGAVTKRGGL SSGDPITSVS NTIYSLVIYA QHMVLSYFKS
     GHPHGLLFLQ DQLKFEDMLK VQPLIVYSDD LVLYAESPSM PNYHWWVEHL NLMLGFQTDP
     KKTTITDSPS FLGCRIINGR QLVPNRDRIL AALAYHMKAS NVSEYYASAA AILMDSCACL
     EYDPEWFEEL VVGIAQCARK DGYSFPGPPF FLSMWEKLRS NHEGKKSRMC GYCGAPAPYA
     TACGLDVCVY HTHFHQHCPV IIWCGHPAGS GSCSECEPPL GKGTSPLDEV LEQVPYKPPR
     TVIMHVEQGL TPLDPGRYQT RRGLVSVRRG IRGNEVDLPD GDYASTALLP TCKEINMVAV
     ASNVLRSRFI IGPPGAGKTH WLLQQVQDGD VIYTPTHQTM LDMIRALGTC RFNVPAGTTL
     QFPAPSRTGP WVRILAGGWC PGKNSFLDEA AYCNHLDVLR LLSKTTLTCL GDFKQLHPVG
     FDSHCYVFDI MPQTQLKTIW RFGQNICDAI QPDYRDKLMS MVNTTRVTYV EKPVRYGQVL
     TPYHRDREDG AITIDSSQGA TFDVVTLHLP TKDSLNRQRA LVAITRARHA IFVYDPHRQL
     QSMFDLPAKG TPVNLAVHRD EQLIVLDRNN REITVAQALG NGDKFRATDK RVVDSLRAIC
     ADLEGSSSPL PKVAHNLGFY FSPDLTQFAK LPAELAPHWP VVTTQNNERW PDRLVASLRP
     IHKYSRACIG AGYMVGPSVF LGTPGVVSYY LTKFVRGEAQ VLPETVFSTG RIEVDCREYL
     DDREREVAES LPHAFIGDVK GTTVGGCHHV TSKYLPRFLP KESVAVVGVS SPGKAAKAVC
     TLTDVYLPDL EAYLHPETQS RCWKVMLDFK EVRLMVWKDK TAYFQLEGRH FTWYQLASYA
     SYIRVPVNST VYLDPCMGPA LCNRKVVGST HWGADLAVTP YDYGAKIILS SAYHGEMPPG
     YKILACAEFS LDDPVRYKHT WGFESDTAYL YEFTGNGEDW EDYNDAFRAR QKGKIYKANA
     TSMRFHFPPG PVIEPTLGLN
//
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