ID I3R806_HALMT Unreviewed; 1049 AA.
AC I3R806;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=FAD-binding oxidoreductase {ECO:0000313|EMBL:QCQ76203.1};
DE SubName: Full=FAD-dependent oxidoreductase {ECO:0000313|EMBL:AHZ23731.1};
DE SubName: Full=Glycolate oxidase subunit GlcD {ECO:0000313|EMBL:AFK20366.1};
GN Name=glcD1 {ECO:0000313|EMBL:AFK20366.1};
GN OrderedLocusNames=HFX_2688 {ECO:0000313|EMBL:AFK20366.1};
GN ORFNames=BM92_14250 {ECO:0000313|EMBL:AHZ23731.1}, C439_15219
GN {ECO:0000313|EMBL:ELZ99221.1}, E6P09_13340
GN {ECO:0000313|EMBL:QCQ76203.1};
OS Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC
OS 14739 / NCIMB 2177 / R-4) (Halobacterium mediterranei).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=523841 {ECO:0000313|EMBL:AFK20366.1, ECO:0000313|Proteomes:UP000006469};
RN [1] {ECO:0000313|EMBL:AFK20366.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.2087 {ECO:0000313|EMBL:AFK20366.1};
RX PubMed=22247127; DOI=10.1128/AEM.07114-11;
RA Cai S., Cai L., Liu H., Liu X., Han J., Zhou J., Xiang H.;
RT "Identification of the haloarchaeal phasin (PhaP) that functions in
RT polyhydroxyalkanoate accumulation and granule formation in Haloferax
RT mediterranei.";
RL Appl. Environ. Microbiol. 78:1946-1952(2012).
RN [2] {ECO:0000313|EMBL:AFK20366.1, ECO:0000313|Proteomes:UP000006469}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 /
RC R-4 {ECO:0000313|Proteomes:UP000006469}, and CGMCC 1.2087
RC {ECO:0000313|EMBL:AFK20366.1};
RX PubMed=22843593; DOI=10.1128/JB.00880-12;
RA Han J., Zhang F., Hou J., Liu X., Li M., Liu H., Cai L., Zhang B., Chen Y.,
RA Zhou J., Hu S., Xiang H.;
RT "Complete genome sequence of the metabolically versatile halophilic
RT archaeon Haloferax mediterranei, a poly(3-hydroxybutyrate-co-3-
RT hydroxyvalerate) producer.";
RL J. Bacteriol. 194:4463-4464(2012).
RN [3] {ECO:0000313|Proteomes:UP000011603}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 /
RC R-4 {ECO:0000313|Proteomes:UP000011603};
RA Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A.,
RA Eisen J.A., Facciotti M.T.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ELZ99221.1, ECO:0000313|Proteomes:UP000011603}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 {ECO:0000313|EMBL:ELZ99221.1}, and ATCC 33500 / DSM
RC 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
RC {ECO:0000313|Proteomes:UP000011603};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
RN [5] {ECO:0000313|EMBL:AHZ23731.1, ECO:0000313|Proteomes:UP000027075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 {ECO:0000313|EMBL:AHZ23731.1}, and ATCC 33500 / DSM
RC 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
RC {ECO:0000313|Proteomes:UP000027075};
RA Bautista V.;
RT "Transcriptional profiles of Haloferax mediterranei on the basis of
RT nitrogen availability.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AFK20366.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.2087;
RA Wang L., Yang H., Xiang H.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:QCQ76203.1, ECO:0000313|Proteomes:UP000299011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 {ECO:0000313|EMBL:QCQ76203.1}, and ATCC 33500 / DSM
RC 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
RC {ECO:0000313|Proteomes:UP000299011};
RA DasSarma S., DasSarma P., DasSarma S., Fomenkov A., Vincze T., Anton B.P.,
RA Roberts R.J.;
RT "Methylomes of two halophilic Archaea, Haloarcula marismortui and Haloferax
RT mediterranei.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; CP001868; AFK20366.1; -; Genomic_DNA.
DR EMBL; CP007551; AHZ23731.1; -; Genomic_DNA.
DR EMBL; AOLO01000012; ELZ99221.1; -; Genomic_DNA.
DR EMBL; CP039139; QCQ76203.1; -; Genomic_DNA.
DR RefSeq; WP_004060167.1; NZ_CP039139.1.
DR AlphaFoldDB; I3R806; -.
DR STRING; 523841.HFX_2688; -.
DR PaxDb; 523841-HFX_2688; -.
DR GeneID; 40157419; -.
DR KEGG; hme:HFX_2688; -.
DR PATRIC; fig|523841.21.peg.3072; -.
DR eggNOG; arCOG00337; Archaea.
DR HOGENOM; CLU_010756_0_0_2; -.
DR OrthoDB; 2837at2157; -.
DR Proteomes; UP000006469; Chromosome.
DR Proteomes; UP000011603; Unassembled WGS sequence.
DR Proteomes; UP000027075; Chromosome.
DR Proteomes; UP000299011; Chromosome.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProt.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR004017; Cys_rich_dom.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR009051; Helical_ferredxn.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR PANTHER; PTHR11748:SF119; D-2-HYDROXYGLUTARATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR Pfam; PF02754; CCG; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
FT DOMAIN 73..309
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 1049 AA; 114330 MW; 4118ACF64444CC75 CRC64;
MVGDDSSWPN RATTAVDEGD LSDFRRFQES RDYEVSDVAA HAELASDLRD AVEGEVRFDE
YTQVLYATDG SIYRARPAGV VIPRDPDDVR AAVEIAVAHD VPILPRGAGS SLAGQTVGPG
CVVLDFSKYM DDIVAVDPEN RRATVQPGVV QDDLDDRLSA HGLKFAPDPA SSNRATIGGG
IGNNSTGAHS VRYGITDAYT EELRVVLADG SLMHTRDVVV GSDEWDDIVA KDDREAEIYR
TVVRLVEENE TEIEQRYPEL KRCVSGYNLH KVVFENDDGE TVVNLSKLFV GAEGTLGVVV
EATVSLVTVP EETALVLYAY DDLLDAMTAV PDALDFDASA VELMDDEVFR MAAESSEYAQ
YVEGIPDGTA ATLMLEFDSE LHDDFEAVIQ AANDHFLRSE SKAEAESKAE AELKSEADDG
RAFDAIEAYT DEAQANLWKL RKAAIPLLMS LQGDPKPYPF IEDASVPPEE LAEYVQSFED
VLADHGTSAA YFAHAGAGTL HIRPILNLKD RDGIETMRSI TDDVTDLVLE HHGAFSGEHG
DGLARTEWNP KMYGPALWDA FKQVKSAFDP DWRMNPGKVV YRSDDPTDMR ENLRYGASYA
SLEPATTLEF EDEGGFSHLV ELCNGCGTCR QTGSETMCPT YRASKDEAET TRGRANMLRA
AISGDLPEEE LYTDRFQEEI LGLCIGCKGC KNDCPTGVDL AKLKAEVKHK HHAEAGASIR
ERLFANIDRF ARLGSVLAPV SNWAAELPGA RDAMDRLVGI ASDRELPSFT SNTLEQWMKF
REATVSQAEA THRVLLFPDT YTNYVTPEIG KAAVRTLEAA GVHVQLAENV HPSGRAAYSG
GFLDLARKRA GHNVEALRPF VEDGWSVVFT EPSDVVMFQD EYDDLLPNEA VAPVGAAAYG
VMEFIDVYRL DEEFPIRGRE STGLGSVGTA GTAVADGGEF GSLTYHGHCN QKALNKDHHA
VGVLRRVGYD VDPLNSGCCG MAGSFGYESE HYDLSKAIGR ILFEKVDESE ADTVVAPGAS
CRSQLAERER EGVHRPAHPI EKVAAALAG
//
