ID I3REY2_9EURY Unreviewed; 735 AA.
AC I3REY2;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Alpha-galactosidase NEW3 domain-containing protein {ECO:0000259|Pfam:PF10633};
GN ORFNames=Py04_1218 {ECO:0000313|EMBL:AFK22792.1};
OS Pyrococcus sp. ST04.
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=1183377 {ECO:0000313|EMBL:AFK22792.1, ECO:0000313|Proteomes:UP000006467};
RN [1] {ECO:0000313|EMBL:AFK22792.1, ECO:0000313|Proteomes:UP000006467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST04 {ECO:0000313|EMBL:AFK22792.1,
RC ECO:0000313|Proteomes:UP000006467};
RX PubMed=22843576; DOI=10.1128/JB.00824-12;
RA Jung J.H., Lee J.H., Holden J.F., Seo D.H., Shin H., Kim H.Y., Kim W.,
RA Ryu S., Park C.S.;
RT "Complete Genome Sequence of the Hyperthermophilic Archaeon Pyrococcus sp.
RT Strain ST04, Isolated from a Deep-Sea Hydrothermal Sulfide Chimney on the
RT Juan de Fuca Ridge.";
RL J. Bacteriol. 194:4434-4435(2012).
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DR EMBL; CP003534; AFK22792.1; -; Genomic_DNA.
DR RefSeq; WP_014734316.1; NC_017946.1.
DR AlphaFoldDB; I3REY2; -.
DR STRING; 1183377.Py04_1218; -.
DR GeneID; 13022468; -.
DR KEGG; pys:Py04_1218; -.
DR eggNOG; arCOG02081; Archaea.
DR eggNOG; arCOG02087; Archaea.
DR HOGENOM; CLU_024113_0_0_2; -.
DR OrthoDB; 110363at2157; -.
DR Proteomes; UP000006467; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1120; Carboxypeptidase-like, regulatory domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR018905; A-galactase_NEW3.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR39198; HYPOTHETICAL MEMBRANE PROTEIN, CONSERVED; 1.
DR PANTHER; PTHR39198:SF1; NPCBM_ASSOC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13620; CarboxypepD_reg; 1.
DR Pfam; PF10633; NPCBM_assoc; 2.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 711..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..272
FT /note="Alpha-galactosidase NEW3"
FT /evidence="ECO:0000259|Pfam:PF10633"
FT DOMAIN 615..690
FT /note="Alpha-galactosidase NEW3"
FT /evidence="ECO:0000259|Pfam:PF10633"
SQ SEQUENCE 735 AA; 82154 MW; 63E4A8DB00569C92 CRC64;
MRQIAVPVLF ILMISLIPTF VFSNEIVQEI TVYSGYLKPG ETLKVDEYKI EVKIGVDGYP
YLFVKGPEGG NFARADFGLK LVLGSVNVIT GRYFDDKGLF LVVTYKVEGE RYQAKSGVYF
EGFSIFSVTN TSVELKYNGN VIKLPTNRSI RINGYLLKFD GDYIYVYRLP TVSLLRSEKS
EGYIVVKFPY KEIFANPGSS VVLPLTIFNN GTNSTVITVS PLSIPEGWNA TFTYNNVEVG
SLEIEPKSYI TLLLTVSIPQ KAEGRHYVSF TINSEVVTLE IDVKHKPEKA EEFKIETPIL
SQEAEAGILL TFPMVVLPPR DVLVTISVKA PEGWRGYALY QGVRVSKIML NKGQAGSLSI
EVEVPRNAEL GSHKVSVELK FYDTDGTLLK SITKEFWVNI YKTYKGEKAT LKLIVVDESG
MPVPRANVQI NEETYGTDSN GMLEVKLDPG EYRIAVSKEG YEKKEEIVKL EDGEIKELKV
MLIKEAYYFD VETESDVYSI VLGEVSVPLT VTIRNLGRND DEYKLKVENL PEAWNAMFSQ
TPEGSIEITT IRVESGKAEN VYLRIYPSLN SKPGIYNLTI VVQSSSGIIK RVPIKVKLIG
SYRLGVNIPN YRMSITAGEE KSTTIALVNF GTAPITNIKI TASGPQGWDI KVSEPSIPIL
DPKDSVRVMI TIKVPEGTPA GDYRVRIQVK SDQQEWQDSI RVVVKQKSTS AYIGLLILVL
AFGIVIYMMR RIGRR
//
