ID I3TGA0_THEC1 Unreviewed; 361 AA.
AC I3TGA0;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region {ECO:0000313|EMBL:AFK51788.1};
GN OrderedLocusNames=TCELL_1366 {ECO:0000313|EMBL:AFK51788.1};
OS Thermogladius calderae (strain DSM 22663 / VKM B-2946 / 1633).
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Thermogladius.
OX NCBI_TaxID=1184251 {ECO:0000313|EMBL:AFK51788.1, ECO:0000313|Proteomes:UP000005270};
RN [1] {ECO:0000313|EMBL:AFK51788.1, ECO:0000313|Proteomes:UP000005270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22663 / VKM B-2946 / 1633
RC {ECO:0000313|Proteomes:UP000005270};
RX PubMed=22843584; DOI=10.1128/JB.00894-12;
RA Mardanov A.V., Kochetkova T.V., Beletsky A.V., Bonch-Osmolovskaya E.A.,
RA Ravin N.V., Skryabin K.G.;
RT "Complete genome sequence of the hyperthermophilic cellulolytic
RT Crenarchaeon 'Thermogladius cellulolyticus' 1633.";
RL J. Bacteriol. 194:4446-4447(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=carbamoyl phosphate + L-ornithine = H(+) + L-citrulline +
CC phosphate; Xref=Rhea:RHEA:19513, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:46911, ChEBI:CHEBI:57743,
CC ChEBI:CHEBI:58228; EC=2.1.3.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001065};
CC -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC superfamily. {ECO:0000256|RuleBase:RU003634}.
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DR EMBL; CP003531; AFK51788.1; -; Genomic_DNA.
DR AlphaFoldDB; I3TGA0; -.
DR STRING; 1184251.TCELL_1366; -.
DR KEGG; thg:TCELL_1366; -.
DR eggNOG; arCOG00912; Archaea.
DR HOGENOM; CLU_043846_3_3_2; -.
DR InParanoid; I3TGA0; -.
DR Proteomes; UP000005270; Chromosome.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0016743; F:carboxyl- or carbamoyltransferase activity; IEA:InterPro.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45753:SF3; ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL; 1.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00101; ATCASE.
DR SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005270};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003634}.
FT DOMAIN 16..173
FT /note="Aspartate/ornithine carbamoyltransferase carbamoyl-P
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02729"
FT DOMAIN 192..354
FT /note="Aspartate/ornithine carbamoyltransferase Asp/Orn-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF00185"
SQ SEQUENCE 361 AA; 41007 MW; DFC9E4BF84DE4E9D CRC64;
MYEMSESWFL GLLEGKHWLS NADYDIDTIF TVLKAAKELK EMFHKGVRKV NWLDGKTLYL
IFYNKSLRTR NSFQTGMYQL GGQAIYISPD QVYTPTLPED MVPYATEAIS DVARVLSRYG
SGIAIRIYGD AAKWIIGRGH RIIQEFAKWS KVPVLNMEDD IWHPFQSLAD ALAAFEALGF
PKDLRGKKVV VSYAYSGGLK PLAVPQDVAT TFAMLGADVY VAHPPGFELL DDVMNKAKKF
AEHWGSEFKI VYNMDEAFEG ATIVYPKAWS PKGFFPPFNS KVDKEGATAY QNKFKDWIVT
TERLEKAGKP FYMHCGPADR GQEVTDEVLD SYPKSLYFEE AENRLHVQKA VMAMTMGSRK
W
//
