ID I3TJZ2_TISMK Unreviewed; 509 AA.
AC I3TJZ2;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains {ECO:0000313|EMBL:AFK53080.1};
GN Name=flbD {ECO:0000313|EMBL:AFK53080.1};
GN OrderedLocusNames=TMO_1241 {ECO:0000313|EMBL:AFK53080.1};
OS Tistrella mobilis (strain KA081020-065).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Geminicoccales;
OC Geminicoccaceae; Tistrella.
OX NCBI_TaxID=1110502 {ECO:0000313|EMBL:AFK53080.1, ECO:0000313|Proteomes:UP000005258};
RN [1] {ECO:0000313|EMBL:AFK53080.1, ECO:0000313|Proteomes:UP000005258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KA081020-065 {ECO:0000313|EMBL:AFK53080.1,
RC ECO:0000313|Proteomes:UP000005258};
RX PubMed=22458477; DOI=10.1021/ja301735a;
RA Xu Y., Kersten R.D., Nam S.J., Lu L., Al-Suwailem A.M., Zheng H.,
RA Fenical W., Dorrestein P.C., Moore B.S., Qian P.Y.;
RT "Bacterial biosynthesis and maturation of the didemnin anti-cancer
RT agents.";
RL J. Am. Chem. Soc. 134:8625-8632(2012).
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DR EMBL; CP003236; AFK53080.1; -; Genomic_DNA.
DR RefSeq; WP_014744759.1; NC_017956.1.
DR AlphaFoldDB; I3TJZ2; -.
DR STRING; 1110502.TMO_1241; -.
DR KEGG; tmo:TMO_1241; -.
DR PATRIC; fig|1110502.3.peg.1278; -.
DR eggNOG; COG2204; Bacteria.
DR HOGENOM; CLU_000445_0_2_5; -.
DR Proteomes; UP000005258; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR002197; HTH_Fis.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR InterPro; IPR025944; Sigma_54_int_dom_CS.
DR PANTHER; PTHR32071:SF21; PROPIONATE CATABOLISM OPERON REGULATORY PROTEIN; 1.
DR PANTHER; PTHR32071; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF02954; HTH_8; 1.
DR Pfam; PF00158; Sigma54_activat; 1.
DR PRINTS; PR01590; HTHFIS.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000313|EMBL:AFK53080.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW Reference proteome {ECO:0000313|Proteomes:UP000005258};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 2..114
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 120..349
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000259|PROSITE:PS50045"
FT MOD_RES 52
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 509 AA; 54518 MW; AB58B2C46505E79A CRC64;
MRLLIIGSLG GQIGAATRIA VSRGAKVSQV PDVEAALDHL RAGHGAELVM VDVGLDIGRL
VRSLEQERIH VSVVACGVGA DAQAAVRAIK AGAREYIPLP PDPELIAAVL EAVASEDHAL
IFRDPAMERV VSLAEQIAPA DATVLITGES GTGKEVMARF LHRKSRRADQ RFVSVNCAAI
PENLLESELF GHEKGAFTGA VARRVGKFEE ADGGTLLLDE ISEMDPRLQA KLLRVIQERE
VDRVGGTRPV KVDIRLIATS NRNLEDEVRR GNFREDLYFR LNVVNLRLPS LRERPSDVAA
LADHFVQRYA AANALPDRPL SPDARNLLLT YDWPGNVREL ENTMHRAVLL ARGTEIGAEA
IMLADGTSLA TAAARRQDFQ PPRAPAAPAG VPAHNPYANP YGGPPAAYGV PPAAYGQPAG
FAPAAPAAPV AADDEDATRA LVGRTVAEVE RDLIINTIQH CLGNRTHAAT ILGISIRTLR
NKLKLYAEEG VAVPPPAGGD FERSGAYDR
//
