ID   I3TUH3_TISMK            Unreviewed;       479 AA.
AC   I3TUH3;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:AFK56411.1};
GN   OrderedLocusNames=TMO_b0403 {ECO:0000313|EMBL:AFK56411.1};
OS   Tistrella mobilis (strain KA081020-065).
OG   Plasmid pTM2 {ECO:0000313|EMBL:AFK56411.1,
OG   ECO:0000313|Proteomes:UP000005258}.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Geminicoccales;
OC   Geminicoccaceae; Tistrella.
OX   NCBI_TaxID=1110502 {ECO:0000313|EMBL:AFK56411.1, ECO:0000313|Proteomes:UP000005258};
RN   [1] {ECO:0000313|EMBL:AFK56411.1, ECO:0000313|Proteomes:UP000005258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KA081020-065 {ECO:0000313|Proteomes:UP000005258};
RC   PLASMID=Plasmid pTM2 {ECO:0000313|Proteomes:UP000005258};
RX   PubMed=22458477; DOI=10.1021/ja301735a;
RA   Xu Y., Kersten R.D., Nam S.J., Lu L., Al-Suwailem A.M., Zheng H.,
RA   Fenical W., Dorrestein P.C., Moore B.S., Qian P.Y.;
RT   "Bacterial biosynthesis and maturation of the didemnin anti-cancer
RT   agents.";
RL   J. Am. Chem. Soc. 134:8625-8632(2012).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP003238; AFK56411.1; -; Genomic_DNA.
DR   RefSeq; WP_014753163.1; NC_017966.1.
DR   AlphaFoldDB; I3TUH3; -.
DR   KEGG; tmo:TMO_b0403; -.
DR   PATRIC; fig|1110502.3.peg.4662; -.
DR   HOGENOM; CLU_005391_0_0_5; -.
DR   Proteomes; UP000005258; Plasmid pTM2.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07106; ALDH_AldA-AAD23400; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR044086; LUC3-like.
DR   PANTHER; PTHR11699:SF263; ALDEHYDE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}; Plasmid {ECO:0000313|EMBL:AFK56411.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005258}.
FT   DOMAIN          20..465
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        245
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   479 AA;  51508 MW;  600641F917AE06C6 CRC64;
     MSDHQPSPTM TINGHGVTSS QVIEVINPAT SEVFATAPDC SREQLDAAVE TAQQAWESWR
     RTPVAERQAA VRGVARVLRG HADELARLFT AEQGRPLKAA RQEITGAADW LDVVAGMTPP
     EHLTEMPDGQ RMHTRHVPLG VICAIAPWNF PVSLAMWKLG PALVAGNTVV LKPSPFTPLC
     TLRIGELLRD VLPAGVLNVI SGSDRLGPWM TAHPGFAKIS FTGSTATGKA VLASAAADLK
     RVTLELGGND AAIVMPDVDV DTVAQKIFFG AFFNTAQICV ATKRLYVHED IYDALRDRLV
     AIARSVKMGD GTEQGTVLGP IQNRRQFDRV MELLDDARRN GLTLLQGADV PASGYFIPVT
     IVDNPPEASR VVQEEAFGPV LPMMRFSDVD EVIARANDSP YGLAGAVWSA DEVAAIAIAE
     RLETGTVWIN QNLNIRPDTP FAGHKQSGFG VENGMEGLLE YTVPQAIHLP PLAARRGGS
//