ID   I3TX36_TISMK            Unreviewed;       328 AA.
AC   I3TX36;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=LysR family transcriptional regulator {ECO:0000313|EMBL:AFK57324.1};
GN   Name=nahR {ECO:0000313|EMBL:AFK57324.1};
GN   OrderedLocusNames=TMO_c0714 {ECO:0000313|EMBL:AFK57324.1};
OS   Tistrella mobilis (strain KA081020-065).
OG   Plasmid pTM3 {ECO:0000313|EMBL:AFK57324.1,
OG   ECO:0000313|Proteomes:UP000005258}.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Geminicoccales;
OC   Geminicoccaceae; Tistrella.
OX   NCBI_TaxID=1110502 {ECO:0000313|EMBL:AFK57324.1, ECO:0000313|Proteomes:UP000005258};
RN   [1] {ECO:0000313|EMBL:AFK57324.1, ECO:0000313|Proteomes:UP000005258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KA081020-065 {ECO:0000313|EMBL:AFK57324.1,
RC   ECO:0000313|Proteomes:UP000005258};
RC   PLASMID=Plasmid pTM3 {ECO:0000313|Proteomes:UP000005258};
RX   PubMed=22458477; DOI=10.1021/ja301735a;
RA   Xu Y., Kersten R.D., Nam S.J., Lu L., Al-Suwailem A.M., Zheng H.,
RA   Fenical W., Dorrestein P.C., Moore B.S., Qian P.Y.;
RT   "Bacterial biosynthesis and maturation of the didemnin anti-cancer
RT   agents.";
RL   J. Am. Chem. Soc. 134:8625-8632(2012).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000256|ARBA:ARBA00009437}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP003239; AFK57324.1; -; Genomic_DNA.
DR   AlphaFoldDB; I3TX36; -.
DR   KEGG; tmo:TMO_c0714; -.
DR   PATRIC; fig|1110502.3.peg.5590; -.
DR   HOGENOM; CLU_039613_39_0_5; -.
DR   Proteomes; UP000005258; Plasmid pTM3.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08465; PBP2_ToxR; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30118; HTH-TYPE TRANSCRIPTIONAL REGULATOR LEUO-RELATED; 1.
DR   PANTHER; PTHR30118:SF15; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Plasmid {ECO:0000313|EMBL:AFK57324.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005258}.
FT   DOMAIN          34..91
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50931"
SQ   SEQUENCE   328 AA;  36761 MW;  0B3FFC741DB4B841 CRC64;
     MMNLHVHQMQ YLLREWKFGY NIPYMQQMNN LRGIDLNLLV VLDALLAERH VSRAAARLNM
     SQPAVSHALG RLRHLFDDPL LIRRNGQLTP SARALDIAPA LTEALRQLQE VLGPGGFDPA
     QEMRRFRLAM SDYGSAVILP DLLNMLRREA PGVELVITQA SREAMLRQVL DGECDLALGV
     FPDLPPRIEA ERLFDEHFAC LADRQGLDGR DRLDLAAYLA RPHVLVAMQN DADTGIDTAL
     HAIGHTRRIV VTLPHWGTAP RLIRGTDLVL TVARKTLALC EDDPVLAVFA PPFAIPPFPF
     VQVWHERRSS DPAHLWLRRA VASTSTSD
//