ID I3TX49_TISMK Unreviewed; 1160 AA.
AC I3TX49;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Amino acid adenylation domain protein {ECO:0000313|EMBL:AFK57337.1};
GN OrderedLocusNames=TMO_c0727 {ECO:0000313|EMBL:AFK57337.1};
OS Tistrella mobilis (strain KA081020-065).
OG Plasmid pTM3 {ECO:0000313|EMBL:AFK57337.1,
OG ECO:0000313|Proteomes:UP000005258}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Geminicoccales;
OC Geminicoccaceae; Tistrella.
OX NCBI_TaxID=1110502 {ECO:0000313|EMBL:AFK57337.1, ECO:0000313|Proteomes:UP000005258};
RN [1] {ECO:0000313|EMBL:AFK57337.1, ECO:0000313|Proteomes:UP000005258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KA081020-065 {ECO:0000313|EMBL:AFK57337.1,
RC ECO:0000313|Proteomes:UP000005258};
RC PLASMID=Plasmid pTM3 {ECO:0000313|Proteomes:UP000005258};
RX PubMed=22458477; DOI=10.1021/ja301735a;
RA Xu Y., Kersten R.D., Nam S.J., Lu L., Al-Suwailem A.M., Zheng H.,
RA Fenical W., Dorrestein P.C., Moore B.S., Qian P.Y.;
RT "Bacterial biosynthesis and maturation of the didemnin anti-cancer
RT agents.";
RL J. Am. Chem. Soc. 134:8625-8632(2012).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003239; AFK57337.1; -; Genomic_DNA.
DR AlphaFoldDB; I3TX49; -.
DR KEGG; tmo:TMO_c0727; -.
DR PATRIC; fig|1110502.3.peg.5603; -.
DR HOGENOM; CLU_000022_2_17_5; -.
DR Proteomes; UP000005258; Plasmid pTM3.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR44845:SF6; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR PANTHER; PTHR44845; CARRIER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 1.
DR PIRSF; PIRSF001617; Alpha-AR; 3.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Plasmid {ECO:0000313|EMBL:AFK57337.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005258}.
FT DOMAIN 679..754
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1160 AA; 122609 MW; 14518DD73F26FFAA CRC64;
MSAPDQALCR TRGAIPLDRL PALLAVLVHR WRALPQPRIA VADAGGLRIL ALEVTADARL
GDLVPEGPTP DATEGPADAL LVPEPAGDLP AVALALRVEA DGRLRVVLDR RLCRPPFDEA
RASDLAHALD RLIAAGADAA LGAVDLISPA RRYELLIERN GPRRPCPTAP AIPDAIRAIA
RRDPQRVALV HETARLTFGE LDARADRLAA MLAARGVGRG DMLPLLMPNG LELPLAMLAA
MKLGAPFVPM DDGWAPERIA ALLDALAPRL VIAADPAVVP PGVAALILDH AAILPAETPF
DAVAVDGRDP IYGFYTSGTT GLPKCAINLH GGLLNRFGVM TRRFAADGRP PVVLQNSRHV
FDSSIWQLLW PLTIGGRVII PRTRGVLDLE TTLRTIAAHE IEMTDFVPSI FNAMVDLMVA
EPGLVRRLGS LRHLLIGGEE IDPRAVRRFR RMLPGIGIVN TYGPTEASIG MVFHHVGDAD
DRSIPIGTPI DNTVAVVVDD HGFIAPPGMV GEIRIGGACL GGGYLGAPEK TAAAHVDNPF
PELPGDRLYR TGDLGYWRRD GRLAYVGRRD DQVKIGGVRI ELGEIEGALA DHPDIRAGRV
VVHEQGGRRE LVACLIGHGE VDTADLRRFL ATRLPRQALP ARLLVLDALP LNANGKVDRR
ALARLANDRL EAAAAADAGF TDPTSAALAA RWRATLQLAP AGPEDGFFDL GGTSLTALVL
AMDLTRHFGM RISVADIFTH PTLGALAALI DRRRRGEETG SAPVPAPEVR LADDIRPSAG
AAAWTPPSGR VRVLLTGATG FVGAHLLPAL LARPDVDLVC LVRAEDDAAA ALRLGIAADR
VTVLAGDLAL PQLGLGDAVW RRLAEGIDVI VNAGALVNLL HGYAAHAAAN VAGVETLLRL
AVTGVPKHVH QVSTLSVFAR SPGHDAVTEA DAADPRALPQ DGYSRSKWAA ERLIDEARRR
GITGSLHRLG EMLPARRSGL GNPQALVERL TAACLRLGLR FPTGLRFDYS PVDIVAAFVA
ARLTEPAGTF HLYGPGTRFE DLLDEAEAAG IALTPVSYAA FHERLSRAAA SDVDAAALLA
LLPDPAGDAG ADAFATADLV ADKDLMFGDA ASRAAMAAAG LAWPAVDAGL LAPWFARRRA
ACPHPSGDVF SDESASEETA
//
