ID I3UDI7_ADVKW Unreviewed; 320 AA.
AC I3UDI7;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase nad-binding protein {ECO:0000313|EMBL:AFK63075.1};
GN OrderedLocusNames=TKWG_15315 {ECO:0000313|EMBL:AFK63075.1};
OS Advenella kashmirensis (strain DSM 17095 / LMG 22695 / WT001)
OS (Tetrathiobacter kashmirensis).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae.
OX NCBI_TaxID=1036672 {ECO:0000313|EMBL:AFK63075.1, ECO:0000313|Proteomes:UP000005267};
RN [1] {ECO:0000313|EMBL:AFK63075.1, ECO:0000313|Proteomes:UP000005267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17095 / LMG 22695 / WT001
RC {ECO:0000313|Proteomes:UP000005267};
RX PubMed=21914874; DOI=10.1128/JB.05781-11;
RA Ghosh W., George A., Agarwal A., Raj P., Alam M., Pyne P., Das Gupta S.K.;
RT "Whole-genome shotgun sequencing of the sulfur-oxidizing chemoautotroph
RT Tetrathiobacter kashmirensis.";
RL J. Bacteriol. 193:5553-5554(2011).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP003555; AFK63075.1; -; Genomic_DNA.
DR RefSeq; WP_014751166.1; NC_017964.1.
DR AlphaFoldDB; I3UDI7; -.
DR STRING; 1036672.TKWG_15315; -.
DR KEGG; aka:TKWG_15315; -.
DR HOGENOM; CLU_019796_1_3_4; -.
DR OrthoDB; 9805416at2; -.
DR Proteomes; UP000005267; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12162; 2-Hacid_dh_4; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 26..316
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 110..290
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 320 AA; 34752 MW; D7394465E3FDD590 CRC64;
MSSSARIVFL DRATLPDFIA LKAFEFEHEV IAYDQTAPAD VAQRIRNAQI VITNKVPVSA
QDVAQAGELK LVAVAATGTN IVDIEACRDK GIVVTNIRNY AVNTVPEHTL ALIFALRRSL
LPYHRSVGQG RWAQSGQFCY FDYPVSDLAD STIGIFGSGA LGSAVARRAQ ALGMKVLFAA
RKGETEVKET HTPFEEVIAQ ADILTLHLPL TPATRHMIGA AELAQMKPTA LLINTARGGL
VDEAALAEAL ENNSIGGAGF DVVTQEPMPD THPFMRLMNR PDFILTPHVA WASRQAIQSL
ADQLVDNINA FVRNDIRNQV
//
