ID I3VSF1_THESW Unreviewed; 859 AA.
AC I3VSF1;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN OrderedLocusNames=Tsac_0416 {ECO:0000313|EMBL:AFK85446.1};
OS Thermoanaerobacterium saccharolyticum (strain DSM 8691 / JW/SL-YS485).
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Thermoanaerobacterium.
OX NCBI_TaxID=1094508 {ECO:0000313|EMBL:AFK85446.1, ECO:0000313|Proteomes:UP000006178};
RN [1] {ECO:0000313|Proteomes:UP000006178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8691 / JW/SL-YS485 {ECO:0000313|Proteomes:UP000006178};
RA Brown S.D., Land M.L., Herring C.D.;
RT "Thermoanaerobacterium saccharolyticum JW/SL-YS485.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFK85446.1, ECO:0000313|Proteomes:UP000006178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8691 / JW/SL-YS485 {ECO:0000313|Proteomes:UP000006178};
RX PubMed=24907337; DOI=10.1128/AEM.00998-14;
RA Currie D.H., Guss A.M., Herring C.D., Giannone R.J., Johnson C.M.,
RA Lankford P.K., Brown S.D., Hettich R.L., Lynd L.R.;
RT "Profile of Secreted Hydrolases, Associated Proteins, and SlpA in
RT Thermoanaerobacterium saccharolyticum during the Degradation of
RT Hemicellulose.";
RL Appl. Environ. Microbiol. 80:5001-5011(2014).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC ECO:0000256|PIRNR:PIRNR000111}.
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DR EMBL; CP003184; AFK85446.1; -; Genomic_DNA.
DR AlphaFoldDB; I3VSF1; -.
DR SMR; I3VSF1; -.
DR STRING; 1094508.Tsac_0416; -.
DR KEGG; tsh:Tsac_0416; -.
DR PATRIC; fig|1094508.3.peg.421; -.
DR eggNOG; COG1012; Bacteria.
DR eggNOG; COG1454; Bacteria.
DR BioCyc; TSAC1094508:GLMA-415-MONOMER; -.
DR BRENDA; 1.1.1.1; 6289.
DR BRENDA; 1.1.1.27; 6289.
DR BRENDA; 1.2.1.10; 6289.
DR Proteomes; UP000006178; Chromosome.
DR GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR CDD; cd08178; AAD_C; 1.
DR CDD; cd07122; ALDH_F20_ACDH; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR034789; AAD_C.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012079; Bifunc_Ald-ADH.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR PIRSF; PIRSF000111; ALDH_ADH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00913; ADH_IRON_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000111}.
FT DOMAIN 10..405
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT DOMAIN 460..847
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
FT COILED 783..830
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 859 AA; 94804 MW; 3CD0DD8A870D1710 CRC64;
MATTKTELDV QKQIDLLVSR AQEAQKKFMS YTQEQIDAIV KAMALAGVDK HVELAKMAYE
ETKMGVYEDK ITKNLFATEY VYHDIKNEKT VGIINENIEE NYMEVAEPIG VIAGVTPVTN
PTSTTMFKCL ISIKTRNPII FSFHPKAIKC SIAAAKVMYE AALKAGAPEG CIGWIETPSI
EATQLLMTHP GVSLILATGG AGMVKAAYSS GKPALGVGPG NVPCYIEKSA NIKRAVSDLI
LSKTFDNGVI CASEQAVIID EEIADEVKKL MKEYGCYFLN KDEIKKLEKF AIDEQSCAMS
PAVVGQPAAK IAEMAGFKVP EGTKILVAEY EGVGPKYPLS REKLSPILAC YTVKDYNEGI
KKCEEMTEFG GLGHSAVIHS ENQNVINEFA RRVRTGRLIV NSPSSQGAIG DIYNTNTPSL
TLGCGSMGRN STTDNVSVKN LLNIKRVVIR KDRMKWFKIP PKIYFESGSL QYLCKVKRKK
AFIVTDPFMV KLGFVDKVTY QLDKANIEYE IFSEVEPDPS VDTVMNGVKI MNSYNPDLII
AVGGGSAIDA AKGMWLFYEY PDTEFETLRL KFADIRKRAF KFPELGKKAL FIAIPTTSGT
GSEVTAFAVI TDKKRNIKYP LADYELTPDI AIIDPDLTKT VPPSVTADTG MDVLTHAIEA
YVSVMASDYT DALAEKAIKI VFEYLPRAYK NGNDEEAREK MHNASCMAGM AFTNAFLGIN
HSMAHILGGK FHIPHGRANA ILLPYVIRYN AEKPTKFVAF PQYEYPKAAE RYAEIAKFLG
LPASTVEEGV ESLIEAIKNL MKELNIPLTL KDAGINKEQF EKEIEEMSDI AFNDQCTGTN
PRMPLTKEIA EIYRKAYGA
//
