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Database: UniProt
Entry: I3WFD5_BIFBI
LinkDB: I3WFD5_BIFBI
Original site: I3WFD5_BIFBI 
ID   I3WFD5_BIFBI            Unreviewed;       529 AA.
AC   I3WFD5;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   05-JUL-2017, entry version 41.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AFL03598.1};
GN   ORFNames=BBB_0001 {ECO:0000313|EMBL:AFL03598.1};
OS   Bifidobacterium bifidum BGN4.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=484020 {ECO:0000313|EMBL:AFL03598.1, ECO:0000313|Proteomes:UP000006173};
RN   [1] {ECO:0000313|EMBL:AFL03598.1, ECO:0000313|Proteomes:UP000006173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGN4 {ECO:0000313|EMBL:AFL03598.1};
RX   PubMed=22887663; DOI=10.1128/JB.00988-12;
RA   Yu D.S., Jeong H., Lee D.H., Kwon S.K., Song J.Y., Kim B.K.,
RA   Park M.S., Ji G.E., Oh T.K., Kim J.F.;
RT   "Complete Genome Sequence of the Probiotic Bacterium Bifidobacterium
RT   bifidum Strain BGN4.";
RL   J. Bacteriol. 194:4757-4758(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001361; AFL03598.1; -; Genomic_DNA.
DR   RefSeq; WP_003815030.1; NC_017999.1.
DR   EnsemblBacteria; AFL03598; AFL03598; BBB_0001.
DR   KEGG; bbf:BBB_0001; -.
DR   PATRIC; fig|484020.3.peg.1; -.
DR   KO; K02313; -.
DR   Proteomes; UP000006173; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006173};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006173}.
FT   DOMAIN      218    357       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      433    502       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     226    233       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   529 AA;  58561 MW;  78C1F26BDA9F1AE8 CRC64;
     MSDDLLGPAG QATRIWSDTL RLLKQNPTLS PRDKSWLEGV VPEAVYGTTI VLCVSNMATQ
     QALQNELNAP LLNALKIISG NDMFPAFKIV APQVSQPEPQ PPEYRHPDTA AKPSEPFPAN
     PSPTVADLAQ ESYMPNSMQS ISSIDSISAE MTEANQQPGA TAPRIPGEPS FPVRQQKVMR
     DPETHLNKNS TFDTFVPGDS NRFARTVALA VAEGTGQEFN PLCIYGGSGL GKTHLLNAIG
     NYALVKDPTL KVRYVNSEEF TNEFIEALQT PAQSQNRIAE FNRRYREVDV LLIDDIQFLG
     GKEATLEQFF HTFNALHQAN KRIVIASDVA PKNLKGFEAR LISRFDSGLT VDVKPPDLET
     RIAILRMMAS MNGTSTPNDV LNLIAERFTE NIRELEGALI RVSAVASLSS QPVTRALAEQ
     TLQDFFTTDV EIKPTDIIGQ TAKYFHLTFD DIVGRARTKN IALARQVAMY LAREMTSMSL
     VDIGEVFGGR DHTTVMHAYT RVSDDMQEKP EIYNYVTELT ARLKQRGNE
//
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