ID I3XWH8_SULBS Unreviewed; 311 AA.
AC I3XWH8;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) {ECO:0000313|EMBL:AFL68302.1};
DE EC=2.1.1.10 {ECO:0000313|EMBL:AFL68302.1};
GN OrderedLocusNames=Sulba_1003 {ECO:0000313|EMBL:AFL68302.1};
OS Sulfurospirillum barnesii (strain ATCC 700032 / DSM 10660 / SES-3).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Sulfurospirillaceae; Sulfurospirillum.
OX NCBI_TaxID=760154 {ECO:0000313|EMBL:AFL68302.1, ECO:0000313|Proteomes:UP000006176};
RN [1] {ECO:0000313|EMBL:AFL68302.1, ECO:0000313|Proteomes:UP000006176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700032 / DSM 10660 / SES-3
RC {ECO:0000313|Proteomes:UP000006176};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Lu M., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Pagani I., Stolz J., Arkin A.,
RA Dehal P., Oremland R., Saltikov C., Basu P., Hollibaugh J., Newman D.,
RA Stolyar S., Hazen T., Woyke T.;
RT "Complete sequence of Sulfurospirillum barnesii SES-3.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU00333};
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DR EMBL; CP003333; AFL68302.1; -; Genomic_DNA.
DR RefSeq; WP_014769181.1; NC_018002.1.
DR AlphaFoldDB; I3XWH8; -.
DR STRING; 760154.Sulba_1003; -.
DR KEGG; sba:Sulba_1003; -.
DR PATRIC; fig|760154.4.peg.1002; -.
DR eggNOG; COG2040; Bacteria.
DR HOGENOM; CLU_004914_3_2_7; -.
DR OrthoDB; 9803687at2; -.
DR Proteomes; UP000006176; Chromosome.
DR GO; GO:0008898; F:S-adenosylmethionine-homocysteine S-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0061627; F:S-methylmethionine-homocysteine S-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.330; Homocysteine-binding-like domain; 1.
DR InterPro; IPR017226; Betaine-hCys_S-MeTrfase_BHMT.
DR InterPro; IPR003726; HCY_dom.
DR InterPro; IPR036589; HCY_dom_sf.
DR PANTHER; PTHR46015:SF1; ZGC:171603 PROTEIN; 1.
DR PANTHER; PTHR46015; ZGC:172121; 1.
DR Pfam; PF02574; S-methyl_trans; 1.
DR PIRSF; PIRSF037505; Betaine_HMT; 2.
DR SUPFAM; SSF82282; Homocysteine S-methyltransferase; 1.
DR PROSITE; PS50970; HCY; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00333};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU00333};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00333}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00333}.
FT DOMAIN 2..309
FT /note="Hcy-binding"
FT /evidence="ECO:0000259|PROSITE:PS50970"
FT BINDING 229
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 294
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 295
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
SQ SEQUENCE 311 AA; 34120 MW; 02E1576EF36B0D1A CRC64;
MNPLTPFLEA QKVFILDGAF GTELERKGYD INDSLWSAKF LMEKPEAIAE VHLDYLNAGS
DCITTASYQA SFEGFMKRGM SEAEAKALIV SSVKIAQKVR DDFWSDTKNH VKRLKPLVAA
SIGPYGAYLA DGSEFRGNYG LSMEALMNFH RKRLLTLIEA KPDLLACETI PCLVEAKALC
ALLEGYPAVS AWVSFSAKDG EHINSGEKVR ECAQFLESQK QIVAIGINCT APQFIESLID
EIKAVSSKPI IVYPNGGSSY NALTKTWDGL SKNASYGKMA YGWYQKGARL IGGCCQTTPE
DIAQIAVWVR A
//
